Danazol

Danazol – the medicine suppressing products of gonadotropic hormones.

Form of release and structure

Dosage form of Danazol – the capsule. Active ingredient – даназол, its content is to 1 capsule 100 or 200 of mg.

Indications to use

• Hereditary Quincke's disease;
• Fibrous and cystous mastopathy and other high-quality new growths of a mammary gland;
• Endometriosis with the accompanying infertility;
• Syndrome of premenstrual tension;
• Primary menorrhagias;
• Gynecomastia.

Contraindications

• Carcinoma;
• Androgenozavisimy tumors;
• Breast cancer;
• Vaginal bleeding of an unspecified etiology;
• Heavy abnormal liver functions and/or kidneys;
• Chronic form of heart failure;
• Thromboembolic disturbances, including in the anamnesis;
• Porphyria;
• Period of pregnancy and breastfeeding;
• Children's and advanced age;
• Hypersensitivity to a danazol.

With care patients are recommended to appoint drug: with diseases of kidneys and/or a liver, cardiovascular system, including arterial hypertension; with the pathologies which are becoming aggravated owing to a liquid delay including epilepsy, a diabetes mellitus, disturbances of lipidic exchange, a polycythemia; at disturbance of plasma mechanisms of a hemostasis, migraine; with androgenic reaction to sex hormones at the previous therapy.

Route of administration and dosage

The doctor appoints dosing and the period of treatment individually, as a rule, in a minimal effective dose.

The maximum daily dose for adult patients – 800 mg.

Side effects

Danazol's use can become the reason of the following side effects:

• From endocrine system: disturbances of a spermatogenesis, rushes of blood to the person, an amenorrhea, the increased sweating, changes of a libido, reduction of the size of mammary glands, vaginita, nervousness, emotional lability, increase in secretion of sebaceous glands, an acne disease, an insignificant hirsutism, an androgenetichesky alopecia, increase in body weight, hypostases, a voice posterization;
• From a nervous system: perhaps – dizziness, a headache, a tremor, weakness, a depression, sleep disorders; seldom – slight increase of intracranial pressure;
• From the alimentary system: increase in activity of hepatic transaminases, functional disturbances of digestive tract; seldom – cholestatic jaundice;
• From a metabolism: disturbances of tolerance of glucose, a giperglyukagonemiya, increase in concentration holesterina-LPNP (lipoproteins of low density) in serum, decrease in concentration holesterina-LPVP (lipoproteins of high density) in serum;
• From system of a hemopoiesis: increase or decrease in quantity of blood cells;
• From cardiovascular system: seldom – arterial hypertension, tachycardia;
• Dermatological reactions: skin rash;
• Others: spasms or myotonia, dorsodynias; seldom – vision disorders.

Special instructions

Drug increases testosterone level in blood and exerts impact on other indicators of the analysis of sex hormones.

At treatment of patients with a diabetes mellitus it is necessary to carry out insulin dose adjustment.

Patients of childbearing age before an initiation of treatment need to make sure of lack of pregnancy, therapy should be begun in the first day of periods.

During administration of drug it is recommended to use non-hormonal contraceptives.

Use of drug is possible at treatment of children with premature sexual development.

Medicinal interaction

At simultaneous use with derivatives of an indandion and anticoagulants of a coumarinic row Danazol strengthens their action, increasing risk of development of bleeding.

Drug influences carbohydrate metabolism, at a combination to peroral hypoglycemic means and insulin, weakens their action, promotes growth

concentration of glucose in blood.

Danazol increases concentration level in a blood plasma of a glucagon, cyclosporine and a takrolimus (the risk of nephrotoxicity increases).

Drug oppresses metabolism of antiepileptic means, such as Phenytoinum, carbamazepine, phenobarbital, simultaneous use causes increase in their concentration in blood.

Danazol can lower effect of anti-hypertensive means.

Drug can cause a hypercalcemia at a combination with alfakaltsidoly at primary hypoparathyroidism.

Terms and storage conditions

To store in the unavailable to children and protected from light place.