Flukonazol

Flukonazol – the drug having the expressed antifungal effect. The mechanism of effect of drug Flukonazol consists in inhibition of the enzymatic activity of mushrooms dependent on P450 cytochrome. Processes of transformation of a lanosterol of a fungal cell into ergosterol are as a result blocked, permeability of a membrane of a cell wall increases, its replication and growth is slowed down. However Flukonazol has the selection activity and does not inhibit similar enzymes in human body cells therefore treatment by Flukonazol rather safe. Drug does not possess anti-androgenic action. Has high activity in case of opportunistic mycoses. Flukonazol's use for prevention of fungal complications for oncological patients at treatment is possible cytostatics, and also in transplantology and other situations when against the background of reduced immunity accession of a fungal infection is possible. At use according to the instruction Flukonazol possesses very powerful antifungal influence. Tell about high performance of drug also reviews of Flukonazola from the practicing doctors.

Flukonazol possesses high absorption. Meal does not influence absorption of this drug. Bioavailability of drug – 90%. In number of 11-12% contacts plasma proteins. Flukonazol's concentration in plasma is directly proportional to a dosage. Drug well gets into all liquid environments of an organism. Flukonazol's concentration in joint liquid, breast milk, peritoneal liquid, a phlegm, saliva is similar that in a blood plasma. High concentration of drug in a vaginal secret is reached in 8 hours after its reception and maintained at the therapeutic level not less days that Flukonazol in treatment of vaginal candidiases allows to apply successfully.

The drug pharmacokinetics directly depends on a condition of the glomerular device of kidneys, at the same time the elimination half-life of Flukonazol is inversely proportional to clearance of creatinine.

Indications to Flukonazol's use

In the instruction to Flukonazol such indications to its use are specified:

• various fungal infections: cryptococcosis, including cryptococcal meningitis, system candidiasis, and also candidiasis of mucous membranes, vaginal candidiasis;
• prevention of fungal complications at patients against the background of the suppressed immunity (treatment by cytostatics, radiation therapy, reception of immunodepressants).

Contraindications to Flukonazol's use

According to the instruction Flukonazol it is impossible to apply at the following states:

• pregnancy, lactation period;
• age up to 16 years;
• hypersensitivity to antifungal drugs in the anamnesis.

With care it is necessary to apply Flukonazol at the liver failure, a concomitant use of a terfinadin, potentially proaritmogenny states caused by organic cardial pathology, disturbances of electrolytic balance, administration of drugs capable to cause arrhythmia.

Side effects

At treatment by Flukonazol side effects meet quite seldom. These are such phenomena as nausea, a meteorism, diarrhea, a hyperbilirubinemia, dizziness, a headache, a leukopenia, a neutropenia, an agranulocytosis, skin rash, fibrillation/trembling of ventricles.

Overdose

At use Flukonazola according to the instruction the overdose is improbable. At overdose the paranoid behavior, hallucinations develops.

Dosage and mode of use of Flukonazol

According to the instruction Flukonazol is used for oral and intravenous administration.

Drug for parenteral use is produced in the form of 0,2% of solution, for oral administration – in the form of the capsules containing 50, 100, 150 and 200 mg of active ingredient. Flukonazol elimination half-life long in this connection drug is used 1 time a day. The medical dose varies in limits 200-400mg. At candidosis damage of mucous membranes the dose makes 50-100mg in days, in case of bacterial candidiasis – 150 mg. In each specific clinical situation the dosage of drug is selected only by the doctor.

Special instructions

At treatment by Flukonazol it is necessary to control hematologic indicators. Treatment should be continued before achievement of a condition of kliniko-hematologic remission. It is possible to begin treatment by Flukonazol without results of crops, but with results of this method of inspection if necessary correction of fungicidal therapy is carried out.

Flukonazol's interaction with other medicines

Flukonazol increases activity of coumarinic anticoagulants, concentration of a zidovudine, cyclosporine, a rifabutin, extends a theophylline elimination half-life, increases plasma concentration of midazolam. It should be considered at purpose of this drug.

Responses

Thanks to high fungicidal activity reviews of Flukonazola from doctors and patients accepting it positive. Efficiency of drug is proved in a number of clinical tests. Drug possesses the minimum hepatotoxic, and the hyperbilirubinemia caused by it stops after the end of treatment by drug, that is is completely reversible.

Storage conditions

Drug Flukonazol should be stored at the room temperature in the place protected from hit of sunshine.

Surely in detail study the instruction to Flukonazol before an initiation of treatment this drug.