Drug is produced Упаковка Фторафур in the form of solid gelatin capsules, with an orange cap and the yellow case. One capsule contains active component – Tegafurum of 400 mg.

Additional components: stearic acid.

Structure of a cover: titanium dioxide, Ponceau 4R, gelatin, Quinoline yellow.

In polyethylene banks on 100 capsules.

Pharmacological action

According to the instruction Phthorafurum is antineoplastic drug which breaks synthesis of RNA and DNA. As a result of hydrolysis it is formed ftoruratsit which slows down synthesis DNA and enzyme to a timidilatsintetaz, instead of uracil is implemented into structure of RNA, forming defect, inhibits cellular proliferation.

In tumor cells Tegafurum turns into 5-fluorine-dezoksiuridin-5-monophosphate which is phosphorylated afterwards in triphosphate and monophosphate which brakes a timidilatsintetaza joins in structure of RNA, and also in a floksuridin.

According to reviews Phthorafurum is not so toxic as it 5-ftoruratsit and is much better transferred by patients.

Indications to use of Phthorafurum

According to the instruction Phthorafurum is shown at cancer of a direct and large intestine, mammary gland and stomach. Also use drug at skin lymphoma and diffusion neurodermatitis.

Route of administration of Phthorafurum and mode of dosing

According to the instruction Phthorafurum is intended for intake.

The daily dosage makes 20-30 mg on the weight kg divided into two-four receptions, but no more than two grams a day. The course dosage makes 30-40 g. The interval between courses makes one month. At patients of old age, and also at a late stage of a disease reduction of a dosage of drug is allowed.

Contraindications

Phthorafurum is contraindicated at:

anemias;
leukopenias;
heavy renal failures and baking;
thrombocytopenia;
disease end-stage;
pregnancy and breastfeeding;
acute profuse bleedings;
hypersensitivity to Tegafurum.

According to reviews patients should appoint Phthorafurum with care with disturbances of functions of kidneys and a liver, a hemopoiesis, glucose metabolism, and also at an ulcer of a 12-perstny gut and a stomach, infectious diseases and to patients with tendency to bleedings.

Side effects of Phthorafurum

Phthorafurum according to reviews can cause the following by-effects:

Sense bodys: dacryagogue, loss of sense of smell, diplopia, fibrosis of the lacrimal channels.
TsNS: confusion of consciousness, euphoria, dizziness, leukoencephalitis symptoms, ataxy, drowsiness.
Alimentary system: vomiting, abdominal pains, nausea, anorexia, diarrhea, esophagitis, stomatitis, gastrointestinal bleedings, cankers of a mucous membrane of a GIT, acute hepatitis, abnormal liver functions, acute pancreatitis.
System of a hemopoiesis: anemia, thrombocytopenia, leukopenia.
Cardiovascular system: stenocardia, myocardial infarction, cardialgia, myocardium ischemia.
Dermatological reactions: disturbance of regeneration of nails and skin, alopecia.
Other side effects: organism dehydration, a renal failure, allergic reactions (up to an acute anaphylaxis), pharyngitis, intersticial pneumonia.

Overdose

The overdose by Phthorafurum according to reviews leads to emergence of the following symptoms: oppression of a hemogenesis and strengthening of side effects from TsNS and a GIT.

In case of overdose it is necessary to control hemopoiesis functions for a month, and if necessary to carry out a symptomatic treatment.

Use of Phthorafurum during pregnancy and breastfeeding

It is contraindicated to apply Phthorafurum at pregnancy and breastfeeding. It is necessary to consider that Tegafurum suppresses reproductive function.

Medicinal interaction

In Phthorafurum combination to Phenytoinum there is strengthening of action of the last.

Toxicity of drug increases at its combination to inhibitors of a microsomal oxidation.

Storage conditions

Drug is released according to the recipe. Store it at the room temperature not longer than four years.

The prices in Internet drugstores:

Name of drug

Price

Drugstore

Phthorafurum капс 400 mg No. 100, Grindex

13693 rub.

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