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Ftoruratsil

Ftoruratsil – antineoplastic drug. Representative of group of antimetabolites.

Pharmacological action

The anti-inflammatory means Упаковка Фторурацилfrom group of antimetabolites reducing the speed of chemical changes necessary for cell fission of a tumor by blocking of formation of DNA, and, in particular, reduction of activity of enzyme of a timidilatsintetaza, and formation of RNA with Ftoruratsil's intervention in its structure.

Release form

Ftoruratsil is issued in the form of solution for intravascular and intracavitary introduction.

Indications to Ftoruratsil's use

According to the instruction Ftoruratsil it is necessary to accept in case of detection at the patient of cancer thick or a rectum, cancer of a gullet, a stomach, primary cancer of a liver, ovarian cancer, cancer of a neck of uterus, bladder cancer, various malignant tumors located on a neck and the head, a prostate cancer, cancer of adrenal glands, cancer of a penis or carcinoid.

Route of administration

The way of introduction, the mode and doses of use of Ftoruratsil in each case decides personally on the patient. All this is defined depending on health of the patient, a stage and degree of a disease, a condition of the hemopoietic system, and the plan of chemotherapy.

Ftoruratsil usually enter into an organism intravenously struyno or kapelno, vnutriarterialno and in-band. There are several standard schemes of treatment by drug Ftoruratsil:

  • 0,5 g/m2 or 12-14 mg/kg every day for 3 - 5 days, a pause between courses 1 month.
  • 0,6 g/m2 one-time in a week, course 6 duration - 10 weeks.
  • 0,6 g/m2 in the 1st and 8th days with other antineoplastic drugs, alternate with introduction intravenously kapelno within 4 – 5 days.

Side effects of Ftoruratsil

According to the instruction Ftoruratsil Фторурацил во флаконеhas a set of possible side effects. According to reviews of Ftoruratsila the most often found side effects are nausea and diarrhea, anemia and a leukopenia are more rare. Disturbances of coagulant system of blood, cardiovascular system, reproductive system, the central nervous system are also possible.

Ftoruratsil can cause collateral dermatological (an alopecia, dermatitis) and allergic (a small tortoiseshell, a bronchospasm) reactions.

Contraindications

Ftoruratsil is contraindicated to use in case of pregnancy and feeding by a breast. It is also contraindicated at detection at the patient of an exacerbation of an ulcer of the duodenum or a stomach, any kind of bleeding and its possible emergence expressed to anemia or a leukopenia, thrombocytopenia.

Ftoruratsil those patients at whom disturbance in work of a liver and kidneys is observed should accept with extra care.

 
 
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