Groprinosin

Groprinosin, active ingredient inosine пранобекс (inosine pranobex) – the antiviral, immunostimulating drug.

Groprinosin is recommended for use in the presence of an insufficient natural host defense for patients.

Pharmacological action Groprinosin

Groprinosin has an antiviral and immunopromoting effect on an organism thanks to a combination of inosine and salt of the 4-acetamidobenzoic acid with N, N-dimethylamino-2-propyl alcohol, a molar ratio 1:3.

The inosine which is present at drug defines efficiency of a complex, and availability to lymphocytes raises the second component as a part of Groprinosin. Stimulating biochemical processes in macrophages, drug promotes increase in development of interleykin, strengthening of development of antibodies, stimulates formation of cytokines owing to proliferation of lymphocytes.

Use Groprinosin promotes reduction of clinical displays of viral diseases, acceleration of reconvalescence, increase in resistance of an organism.

As auxiliary medicine in case of infectious damage of skin and mucous the virus Herpes simplex, Groprinosin promotes more bystry healing of the struck surfaces. Emergence of new bubbles, hypostases, erosion, palindromias decreases.

Owing to the hypotoxicity Groprinosin is well had by patients of advanced age, and also patients with a chronic circulatory unefficiency and stenocardia.

Timely use Groprinosin reduces the frequency of virus infection and reduces weight and duration of diseases.

Release form Groprinosin

Groprinosin – tablets of white color, biconvex. On one of the parties of risk for division. A surface of tablets homogeneous, smooth, without damages and spots.

Groprinosin contains in one tablet the main active ingredient – inosine пранобекс (500 mg), excipients: potato starch (85 mg), поливинлпирролидон K25 (45 mg), magnesium stearate (10 mg).

Packaging on 10 pieces in blisters, cardboard packs on 2 and 5 blisters.

Analogs Groprinosin

Groprinosin's analog on active component – tablets Izoprinozin.

Groprinosin's analogs, relatives on the mechanism of influence and belonging to one pharmacological subgroup:

• Tablets – Alpizarin, Amiksin, Arbidol, Amizon, Virasept, Giporamin, Isentress, Yodantipirin, Kagotsel, Lavomax, Nikavir, Ergoferon, Poliferon-CD4, Tselzentri, Tilaksin, Tiloron;
• Capsules – Arbidol, Ingavirin, Tiloron, ORVITOL of NP;
• Suppositories vaginal – Giporamin, Panavir;
• Suppositories rectal – Giporamin, Panavir;
• Powder for intake – Virasept, Lirasept;
• Nasal ointment – Oxolinum;
• Gel for topical and external use – Panavir;
• Drugs for preparation of solutions for injections, infusions, inhalations – Allokin-alfa lyophilisate, Armenikum, Giporamin, Panavir, Fuzeon;
• Liquid extract for topical administration and intake – Proteflazid;
• Solution for intramuscular injections – Ferrovir.

Indications to use Groprinosin

According to the instruction, Groprinosin is recommended for reception in case of the immunodeficiency of an organism caused by viral infections at the normal or weakened immunity.

Groprinosin, according to the instruction, is appointed in a case:

• The diseases caused by the Herpes simplex I and II viruses like various localization;
• Cytomegalovirus;
• Subacute sclerosing panencephalitis.

Contraindications

According to the instruction, Groprinosin is not applied at:

• To gout;
• Urolithiasis;
• Chronic renal failure;
• Arrhythmias;
• Pregnancies;
• In the period of a lactation;
• Hypersensitivity to drug components.

Groprinosin to children up to 3 years or with body weight less than 15-20 kg is not appointed.

It is necessary to appoint drug with care at a concomitant use with diuretics, a zidovudine, xanthineoxidase inhibitors, and also in case of an acute renal failure.

Route of administration Groprinosin

Groprinosin, according to the instruction – inside after meal 3-4 times a day through identical periods of 6 or 8 hours, washing down a route of administration with a small amount of water.

Adults – 3-4 grams (6-8 tablets) a day, children – at the rate of 50 mg of drug on 1 kg of weight of the child a day.

At Groprinosin's use for children and adults in case of serious infectious diseases it is authorized to increase a drug dose to 100 mg/kg of weight a day, but only individually and under control of the attending physician.

Apply Groprinosin usually 5 days, at complications during a disease reception can be prolonged. The course of treatment repeats in case of need after a break in 8 days.

As the immunostimulator drug is appointed for reception within 3-9 weeks, daily or 3 times a week, a dose at the rate of 50 mg/kg of weight of the patient a day.

Medicinal interaction Groprinosin

At simultaneous use of Groprinosin with immunodepressants the immunostimulating efficiency of drug is weakened.

Groprinosin, according to the instruction, it is necessary to take with caution at a concomitant use with:

• Inhibitors of a xanthineoxidase (Allopyrinolum), loopback diuretics (торасемид, furosemide, Acidum etacrynicum). They increase concentration of uric acid in blood serum;
• Zidovudine. Groprinosin increases concentration of a zidovudine in plasma and the period of its semi-removal.

Side effects Groprinosin

Use Groprinosin, according to reviews, causes side reactions generally in an initiation of treatment.

The most widespread collateral manifestations of use Groprinosin, according to reviews – a loss of appetite, vomiting, nausea, diarrhea. Other reactions – an insignificant allergy, insignificant increase in concentration of uric acid in blood and urine.

Use influence researches Groprinosin on a psychomotor system were not conducted therefore it is necessary to treat with care control of vehicles and other mechanisms during administration of drug as Groprinosin's use, according to reviews, can cause drowsiness and dizziness.

Storage conditions

To store in the unavailable to children, protected from light, dry place. Temperature is not above 25 °C. A period of validity - 3 years of date of production.