Iksel

Iksel – antidepressant means without sedation.

Form of release and structure

Dosage form – capsules: firm gelatinous, with a lid of salmoncolored color with a black text of "IXEL" and the case: the size No. 4 – salmoncolored color with a black print "25", the size No. 3 – yellow-orange color with a black print "50"; contents of capsules – powder from almost white till white color, are allowed presence of the lumps, at easy pressing which are powdered (on 14 pieces in blisters, in a cardboard pack 2 or 4 blisters).

Active ingredient of Iksel – a milnatsipran a hydrochloride, in 1 capsule – 25 or 50 mg.

Auxiliary components: karmelloza of calcium, hydrophosphate calcium dihydrate, K30 povidone, magnesium stearate, silicon dioxide colloid, talc.

Structure of a cover of the capsule: gelatin, ferrous oxide red (E172), titanium dioxide (E171), ferrous oxide yellow (E172).

Indications to use

Iksel's use is shown at treatment of depressive disorders of varying severity.

Contraindications

• Simultaneous use with sumatriptany, non-selective and selection monoamine oxidase inhibitors (MAO) of B type, the MAO selection inhibitors of A type, digoxin;
• Age up to 15 years;
• Obstruction of urinary tract (including against the background of a prostate hyperplasia);
• Period of pregnancy and breastfeeding;
• The accompanying therapy by noradrenaline, adrenaline, a clonidine or its derivatives;
• Hypersensitivity to drug components.

It is necessary to observe extra care at Iksel's appointment to patients with closed-angle glaucoma, convulsive attacks in the anamnesis, epilepsy, a benign hyperplasia (adenoma) of a prostate, a renal failure, arterial hypertension, a cardiomyopathy.

Route of administration and dosage

Capsules should be accepted inside, in the first half of day, it is desirable during food.

The dose and duration of therapy are appointed by the doctor on the basis of individual expressiveness of symptoms.

The recommended average daily dose of-100 mg divided into 2 receptions.

For achievement of steady therapeutic effect at a severe form of a disease increase in a dose is shown, but it is not higher than 250 mg in days.

The patient with a renal failure at the clearance of creatinine (CC) of 50-10 ml/min., it is recommended to lower a daily dose taking into account KK values.

Side effects

• Nervous system: perhaps – dizziness, feeling of alarm; seldom – a headache, a tremor;
• Alimentary system: seldom – nausea, dryness in a mouth, locks, vomiting; in some cases – moderate increase in activity of liver enzymes without clinical symptoms;
• Others: perhaps – inflows, sweating strengthening, the complicated urination; seldom – rash, heartbeat; in some cases – a serotoninovy syndrome.

Special instructions

Because of insignificant increase in heart rate against the background of Iksel's reception, patients with a cardiomyopathy, arterial hypertension should use drug with care.

Emergence of side effects is noted seldom and does not demand drug withdrawal. Undesirable reactions, as a rule, appear during the first 2 weeks of treatment, have insignificant expressiveness and in process of decrease of symptoms of a depression take place independently. For decrease in expressiveness and number of side effects it is recommended to increase in the course of therapy a dose gradually.

It is possible to appoint Iksel after cancellation of MAO inhibitors not earlier than in 2 weeks, and reception of MAO inhibitors should be begun in a week after drug withdrawal.

Alcohol intake during treatment is contraindicated.

Patients should abstain from control of vehicles and mechanisms during the entire period of therapy.

Medicinal interaction

As at simultaneous use of Iksel with sumatriptany, the MAO non-selective inhibitors (Iproniazidum), the MAO selection inhibitors of B type (селегилин) development of a serotoninovy syndrome, spasm of coronary arteries, arterial hypertension is possible, it is necessary to observe strictly a break in 2 weeks between purpose of these drugs.

At a combination to noradrenaline and adrenaline emergence of arterial hypertension, arrhythmia is possible; in need of carrying out local anesthesia against the background of reception of antidepressant of their dose should not exceed 0,1 mg in 10 minutes or 0,3 mg in 60 minutes.

Iksel along with digoxin (is not recommended to appoint especially at injection introduction) as it can cause development of arterial hypertension and tachycardia; a clonidine and similar connections – because of decrease in their hypotensive action.

The accompanying therapy toloksatony, moklobemidy and other MAO selection inhibitors of A type, drugs of lithium poses a threat of emergence of a serotoninovy syndrome.

Terms and storage conditions

To store at a temperature up to 30 °C. To protect from children.

Period of validity – 3 years.