Tablets (on 100, 200 or 300 mg – po10 piece in a blister strip packaging, in a cardboard pack of 2, 5 or 10 packagings, on 50 or 100 pieces in banks from dark glass, in a cardboard pack of 1 bank; on 100 and 300 mg – on 20 pieces in a blister strip packaging, in a cardboard pack of 5 packagings, on 25 pieces in a blister strip packaging, in a cardboard pack 2 or 4 packagings; on 150 mg – on 10 pieces in a blister strip packaging, in a cardboard pack of 5 or 10 packagings; on 100 and 150 mg – po100, 500 or 1000 pieces in polymeric banks; on 200 mg – on 100, 500 or 1000 pieces in banks polymeric or polypropylene; on 300 mg – on 100 pieces in banks polypropylene or polyethylene, in a cardboard pack of 1 bank, on 100, 500 or 1000 pieces in plastic bags, in polymeric banks 1 package);
Solution for injections of 10% (on 5 ml in ampoules – in a pack 5, 10 or in a box of 10 ampoules; in a blister strip packaging of 5 ampoules, in a cardboard pack 2 packagings).

Active agent – an isoniazid:

1 tablet – 100, 150, 200 or 300 mg;
1 ml of solution – 100 mg.

Indications to use

Use of the Isoniazid is shown for prevention and therapy of all active forms of tuberculosis, including tubercular meningitis (as a part of the combined treatment).

For prevention of tuberculosis drug is appointed to children under 4 years with positive skin reaction to tuberculine (more than 10 mm), to the persons which are in close contact with the TB patient, to patients with reaction to tuberculine more than 5 mm and at the instruction on not progressing tuberculosis of radiological data.

Contraindications

Use of drug is contraindicated to patients at the following pathologies:

Poliomyelitis, epilepsy and convulsive attacks in the anamnesis;
Renal failure and/or liver;
Atherosclerosis.

Route of administration and dosage

Pill is taken inside.

Solution is entered intramusculary (in oil), vnutrikavernozno and by means of inhalations.

The doctor establishes a dose of the Isoniazid and the period of treatment individually on the basis of clinical indications, considering age, character and a form of a disease.

The recommended dosing for patients of teenage age and adults:

Tablets: on 300 mg of 1 times a day or from calculation for 15 mg on 1 kg of weight of the patient a day 2-3 times a week (according to the scheme of treatment);
Solution: from calculation for 5 mg on 1 kg of weight of 1 times a day or on 15 mg on 1 kg (also 1 time a day) 2-3 times a week.

The recommended dose for use of tablets and solution for children – on 10-20 mg on 1 kg of weight of 1 times a day or on 20-40 mg on 1 kg according to the scheme of therapy 2-3 times a week;

Daily dose for intra cavernous introduction – 10-15 mg on 1 kg of weight, for inhalations – 5-10 mg on 1 kg a day in 1-2 receptions.

For adults the maximum daily dose for each dosage form – 300 mg.

Side effects

Use of the Isoniazid can cause side effects:

From cardiovascular system: pains in heart;
From the alimentary system: medicinal hepatitis, nausea, vomiting;
From a nervous system: dizziness, headache; seldom – sleep disorders, euphoria, psychosis, peripheral neuritis;
Allergic reactions: itch, skin rash;
From endocrine system: very seldom – women have menorrhagias, men have a gynecomastia.

Special instructions

Isoniazid it is not necessary to appoint in a dose more than 10 mg to 1 kg of weight of the patient at severe forms of arterial hypertension and/or cardiopulmonary insufficiency, widespread atherosclerosis, coronary heart disease, diseases of a nervous system, psoriasis, bronchial asthma, a myxedema, eczema in an aggravation phase.

At purpose of a dose of drug it is necessary to consider extent of influence of genetic factors on acetylation of an isoniazid in a liver, for this purpose it is necessary to determine inactivation speed by its content in urine and blood. The patient with a high speed of an inactivation purpose of the raised drug doses is reasonable.

Not to allow bystry development of stability of a stick of Koch use of an isoniazid combine with other antitubercular drugs.

After injection administration of drug the patient should observe 1-1,5 hours a bed rest.

For reduction of side effect an isoniazid appoint in combination with glutaminic acid (inside), a pyridoxine (inside or in oil), thiamin (in oil).

Medicinal interaction

At a combination to paracetamol, rifampicin the probability of development of a hepatotoxic action, especially at patients with abnormal liver functions increases.

The isoniazid at a concomitant use suppresses metabolism of Phenytoinum and carbamazepine, it promotes increase in level of their concentration in a blood plasma and toxic action.

Terms and storage conditions

To store: tablets – in the dry, protected from light place, solution – in the place protected from light at a temperature of 1-10 °C. To protect from children.

Period of validity: tablets – 6 years, solution – 2 years.

The prices in Internet drugstores:

Name of drug

Price

Drugstore

Isoniazid solution for injections of 10% 5 ml 10 pieces

38 rub.

To buy