Etatsizin

Etatsizin – antiarrhytmic medicine 1C of a class. High pharmakoterapevtichesky performance and clinical safety of drug is mentioned in the majority of responses to Etatsizin.

Amiokordin, Amiodaronum, the Asparkam, Aritmil, Kordaron, Multak, Panangin, Ritmokard, Propanorm, Tiodaron – Etatsizin's drugs analogs entering with it into one pharmacological group.

Structure and form of release

According to the instruction Etatsizin is issued in the form of round tablets (on 0,05 g), and also in the form of 2,5% solution for injections (an ampoule on 2 ml).

0,05 g are a part of each tablet karboetoksiaminodietilaminopropionit a fenotiazin of a hydrochloride, and also auxiliary components (methyl cellulose, potato starch, sucrose, calcium stearate).

Pharmacological action of Etatsizin

Etatsizin slightly reduces the frequency of a sinoatrial rate, slows down atrioventricular, atrial, sinotrialny and intra ventricular conduction. Drug has the moderate coronarodilator, spasmolytic, cholinolytic and expressed antiarrhytmic effect.

Etatsizin's action and Etatsizin's analogs promotes improvement of a functional condition of area of heart with insufficient blood circulation. Etatsizin slows down the speed of increase of the front of action potential, limiting conductivity of natrium channels outside and the interior of a membrane of cardiomyocytes. Besides, drug oppresses calcium channels, having moderate vagolytic effect. All this slows down process of carrying out excitement and promotes suppression of the centers of ectopic automatism in a myocardium of ventricles and auricles.

In 30-60 minutes after reception Etatsizin is found in blood. The maximum concentration in plasma is reached in two-three hours. Etatsizin's bioavailability makes 40%. Drug is metabolized in a liver and removed by kidneys in the form of metabolites. According to the instruction Etatsizin freely gets into breast milk, and also through a placental barrier.

Indications to Etatsizin's use

According to the instruction Etatsizin's use or Etatsizin's analogs is shown at the following diseases:

• Premature ventricular contraction (supraventricular and ventricular);
• Paroxysms of trembling and atrial fibrillation;
• Supraventricular and ventricular tachycardia.

The instruction to use

According to the instruction Etatsizin in the form of tablets it is necessary to accept in an initial dose 50 mg three times a day. If necessary the dose is increased (under control of the electrocardiogram) to 50 mg by four times a day (0,2 g a day) or 0,1 g three times a day (0,3 g a day). At achievement of effect pass to the supporting treatment in individually picked up doses.

Intravenously Etatsizin enter 0,25-1 mg/kg in a dose. Contents of an ampoule of drug are diluted with isotonic solution of sodium chloride. Time of intravenous administration of Etatsizin makes not less than five minutes. More effective at less expressed side effects drop introduction is considered.

Contraindications to Etatsizin's use

• Sinotrialny blockade;
• Ischemic heart disease in an acute form;
• Pregnancy;
• Heart failure;
• Cardiogenic shock;
• Atrioventricular block (II and III degrees);
• The expressed lowering of arterial pressure;
• Disturbances of functions of a liver and kidneys;
• Lactation period;
• Children's age up to eighteen years.

Judging by responses, Etatsizin it is necessary to apply with care at closed-angle glaucoma, a benign hyperplasia of a prostate, cardiomegaly, disturbances of electrolytic balance (a hyperpotassemia, a hypopotassemia, a hypomagnesiemia).

Side effect

In some responses to Etatsizin it is said that at treatment by this drug can arise a sonitus, small drowsiness, a vision disorder and coordination of movements, dizziness, a poshatyvaniye during walking.

Judging by responses to Etatsizin, when using a medicine in the maximum doses the risk of emergence and development of cardial by-effects – intra ventricular, atrioventricular and sinuatrial block, pro-arhythmic effect, symptoms of heart failure increases.

Interaction

Etatsizin's use with other antiarrhytmic drugs 1C (propafenony, allapininy) and an IA class (Ajmalinum, procaineamide, quinidine, Disopyramidum) is contraindicated.

According to the instruction combined use of Etatsizin with MAO inhibitors is not recommended.

One-time use of Etatsizin and beta adrenoblockers can promote strengthening of antiarrhythmic effect.

Conditions and periods of storage

Etatsizin store in the dry, protected from sunshine place.

Period of storage of ampoules 1,5 years, tablets — 2 years.