Эутирокс

Эутирокс – means for completion of a lack of hormones of a thyroid gland.

Pharmacological properties of Eutiroks

According to the instruction of Eutiroks is a synthetic analog of hormone of thyroxine. It fills shortage of hormones at their insufficient education by a thyroid gland. At receipt in an organism drug in a liver and kidneys is exposed to transformation into triiodothyronine which participates in a metabolism, regulates growth and a differentiation of fabrics. Small doses of Eutiroks have anabolic effect on exchange of proteins, fats, average doses accelerate a metabolism, growth, development of fabrics, increase functional activity of heart and brain, high doses of drug by the principle of negative feedback slow down formation of thyrotropin-rileasing-hormone and TTG in a brain that reduces formation of triiodothyronine a thyroid gland.

The medical effect of Eutiroks's use develops 7 – 12 days later from the beginning of administration of drug, it lasts as much after cancellation of medicine. In case of the lowered functional activity of a thyroid gland according to Eutiroks renders positive effect after 3 – 5 days of reception, completely treatment of a diffusion craw is reached in 3 – 6 months.

From a digestive tract of Eutiroks it is soaked up upper parts of intestines, meal worsens drug absorption. In blood practically all it contacts proteins of plasma. The main metabolism happens in a liver, kidneys, muscles, a brain. Removal of means from an organism happens kidneys and through intestines.

Release form

According to the instruction of Eutiroks produce 25, 50, 75, 88, 100, 112, 125, 137 and 150 mkg in tablets.

Indications

Drug is used for correction of reduced work of a thyroid gland – a hypothyroidism, in treatment of an euthyroid craw, diffusion toxic craw (after achievement of a condition of an euthyroidism), after operational treatment of cancer damage of a thyroid gland as replacement therapy and for the prevention of a recurrence of a craw after removal of a part of a thyroid gland. Using Eutiroks carry out various functional tests.

Contraindications

Do not use drug in cases of not treated thyrotoxicosis and adrenal insufficiency, at acute inflammatory damages of heart (myocarditis, a pancarditis), an acute myocardial infarction, intolerance of drug. Carefully it is applied if the patient has accompanying arrhythmias, coronary heart disease, supertension, a diabetes mellitus, it is long the existing hypothyroidism.

Application instruction of Eutiroks

Tablets are intended for reception on an empty stomach (not earlier than 30 min. to food), washing down with water. They cannot be chewed. Depending on indications to Eutiroks the dose is selected in an individual order.

For patients with considerable surplus of body weight the dose is expected the weight must for this growth.

If replacement therapy at a hypothyroidism is required, then to patients aged up to 55 years on condition of absence of heart diseases the recommended dose of 1,6 - 1,8 mkg/kg/days (on average for women of 75 - 100 mkg/days, for males of 100 - 150 mkg/days). If the patient is more than 55 years old or there are accompanying heart diseases, the daily dose makes 0,9 mkg/kg, begin 25 mkg/days with a dose. The dosage is increased if necessary gradually, by 25 mkg in 2 months, to normal values of thyritropic hormone. Constant reception of Eutiroks during life is required.

The heavy hypothyroidism demands careful appointment of Eutiroks from small dosages – 12,5 mkg/days, regularly controlling TTG.

The inborn hypothyroidism from children aged up to 6 months demands purpose of 25 - 50 mkg/days, from 6 to 12 months of 50 - 75 mkg/days, from 1 to 5 years of 75 - 100 mkg/days, from 6 to 12 years of 100 - 150 mkg/days, from 12 years of 100 - 200 mkg/days. To small children drug is appointed to 1 reception (in the morning to food) for life.

In complex treatment of a thyrotoxicosis the daily dose of Eutiroks makes 50 – 100 mkg, at cancer damage of a thyroid gland of 50 - 300 mkg. Duration of treatment is defined individually.

Side effects

According to Eutiroks it is capable to cause allergic reactions occasionally. If precisely to observe a dosage, the risk of undesirable reactions is minimum.