Kanizon

Kanizon – synthetic antifungal means from group of derivatives of an imidazole.

Form of release and structure

• Solution of 1% for external use (on 20 ml in polyethylene bottles, 1 bottle in a pack cardboard);
External
• use cream of 1% (on 20 g in tubas an aluminum, 1 tuba in a pack cardboard);
• Tablets vaginal (on 6 pieces in packaging planimetric bezjyacheykovy, 1 packaging complete with the applicator in a box).

Active agent – Clotrimazolum:

• 1 ml of solution – 10 mg;
• 1 g of cream – 10 mg;
• 1 tablet – 100 mg.

Excipients:

• Solution: propylene glycol, PEG 400, ethanol;
• Cream: paraffin white soft, light liquid paraffin, цетомакрогол 1000, benzyl alcohol, cetostearyl alcohol, EDTA disodium salt, secondary phosphate sodium dodecahydrate, chlorocresol, sodium phosphate a monosubstituted dihydrate, propylene glycol, the water purified;
• Tablets are vaginal: gelatin, starch corn, silicon dioxide colloid, magnesium stearate, lactose, Natrium benzoicum, microcrystallic cellulose, water.

Indications to use

For solution and cream:

• Fungal infections of skin (including pilar parts of a body) and mucous membranes, caused by microorganisms, including drozhzhepodobny and mold mushrooms, dermatophytes, sensitive to Clotrimazolum;
• Mycotic damages of ears;
• The mycoses complicated by a secondary pyoderma;
• Erythrasma;
• Chromophytosis.

For vaginal tablets:

• Colpitis;
• Candidosis vulvovaginitis;
• Candidosis balanitis;
• Other superinfections (including mixed) caused by microorganisms, sensitive to Clotrimazolum;
• Sanitation of a vagina by preparation for childbirth.

Contraindications

All dosage forms of Kanizon are contraindicated at hypersensitivity to drug components.

Vaginal tablets also do not apply in the I trimester of pregnancy.

Tablets in II and III trimesters of pregnancy, and cream and solution during any period of pregnancy can be applied only on doctor's orders if the expected advantage exceeds possible risks.

Nursing mothers are forbidden to apply medicine on mammary glands.

Route of administration and dosage

Cream and solution for external use
In these dosage forms drug is used outwardly.

Means with a thin layer is applied on affected areas of skin and mucous membranes from 2 to 4 times a day. At fungus diseases of skin of legs it is necessary to wash previously feet with warm water with soap and to wipe carefully, especially between fingers.

Duration of therapy is defined individually. On treatment multi-colored depriving usually 1-3 weeks, on therapy of an erythrasma – are required 2-4 weeks. At fungus diseases of skin of legs after disappearance of clinical signs of a disease use of drug is recommended to be continued within 14 days.

In the form of solution Kanizon is also applied at damage of a mucous membrane of an oral cavity: 10-20 drops (0,5-1 ml) of solution by means of a cotton plug or a wadding stick put on mucous 3-4 once a day. Improvement of a state is, as a rule, celebrated for 3-5 day of therapy, however treatment should be continued before full elimination of clinical displays of a disease.

Tablets are vaginal
In this dosage form Kanizon is applied intravaginalno.

The drug is administered deeply in a vagina of 1 times a day, preferably in the evening. Duration of treatment makes 6 days. If necessary the course is repeated.

Use of tablets by means of the applicator:

• To take out a tablet from packaging;
• To enclose in the applicator;
• To enter the applicator deeply into a vagina;
• To press the piston against the stop;
• To remain in a prone position, expecting the tablet will be dissolved so far.

After use the applicator needs to be washed out carefully warm water (not boiled water!).

At a candidosis vulvitis and a candidosis balanitis along with tablets Kanizon is recommended to apply outwardly, on the struck areas, cream (2-3 times a day within 6-12 days).

Side effects

Kanizon is in most cases had well. In rare instances there are local allergic reactions which are shown burning, reddening, an itch and a pricking in the place of use of drug.

At treatment by vaginal tablets are also possible: strengthening of vulval secretion, pain in the bottom of a stomach, hypostasis mucous, irritation mucous after sexual intercourse.

Special instructions

Pill Kanizon is forbidden to be taken inside.

Treatment by vaginal tablets is recommended to be carried out between menstrual cycles.

In order to avoid a reinfitsirovaniye treatment should be undergone to both sexual partners at the same time.

Cream and solution is not recommended to be applied on skin in eyes.

If 4 weeks later after the beginning of use of solution/cream improvement of a clinical state is not noted, it is necessary to see a doctor for specification of the diagnosis.

Medicinal interaction

Kanizon in the form of vaginal tablets reduces action of half-yen antifungal antibiotics (nystatin, Amphotericinum, a natamitsin, etc.).

At topical administration of drug negative interactions with other medicines are not known.

Terms and storage conditions

To store in protected from light, the place, dry, unavailable to children, at a temperature: solution – to 20 ºС, cream and tablets – to 25 ºС.

Period of validity – 3 years.