Kombispazm

Kombispazm – the combined non-steroidal anti-inflammatory drug (NPVS), renders anesthetic, febrifugal, spasmolytic, myotropic and cholinolytic action.

Form of release and structure

Dosage form – tablets No. 10 and No. 100.

Content of active ingredients is to 1 tablet:

• Paracetamol – 0,5 g;
• Dicyclomine a hydrochloride – 0,02 g.

Indications to use

Kombispazm's use is shown for reduction or stopping of a pain syndrome of various genesis:

• Headache;
• Renal colic;
• Dentagra;
• Radiculitis, neuralgia, mialgiya;
• Rheumatic pain;
• Algomenorrhea.

Contraindications

• Glaucoma;
• Myasthenia;
• Disturbance of passability of urinary tract;
• Tachycardia;
• The expressed renal failures and/or a liver;
• Breastfeeding period;
• Age up to 7 years;
• Hypersensitivity to drug components.

With extra care it is necessary to appoint Kombispazm at cardiovascular insufficiency, intestinal impassability, a stenosis of peloric department, ulcer colitis, disturbances of functions of kidneys and/or a liver, a high-quality hyperbilirubinemia, the increased prostate.

Route of administration and dosage

Pill is taken inside, washing down with enough water.

The dose and frequency rate of reception are appointed by the doctor on the basis of clinical indications.

The recommended dosing has age restrictions:

• Patients are more senior than 15 years: on 1-2 tablets 1-4 times a day. Treatment should be begun with 4 tablets a day, for achievement of clinical effect increase in a dose to 8 tablets is allowed (on condition of lack of side effects);
• Children of 7-13 years: on 1/2 tablets 1-2 times a day;
• Children of 13-15 years: on 1 tablet 1-3 times a day.

The maximum daily dose of paracetamol for children should not exceed 0,15 g on 1 kg of weight of the child, for adults – 12 tablets, or 6 g.

Drug should be accepted not more often than 1 time at 4 o'clock.

Side effects

Kombispazm's use can become the reason of side effects:

• Allergic reactions: urticaria, skin rashes, erythema;
• Cardiovascular system: tachycardia, arrhythmia, bradycardia;
• Others: the complicated swallowing, dryness in a mouth and thirst, a lock, accommodation disturbance, increase in intraocular pressure, expansion of pupils, a hyperemia and a xeroderma, the complicated urination; seldom – fever, confusion of consciousness, a leukopenia, an agranulocytosis, thrombocytopenia, a neutropenia.

Reception of high doses during the long period and overdose of drug can cause toxic damage of a liver. Clinical signs of overdose are nausea, vomiting, pallor of skin, an abdominal pain, anorexia. There is an expressed change of laboratory indicators of function of a liver: increase in concentration of bilirubin and activity of liver enzymes, decrease in level of a prothrombin.

Emergence of rashes on a body of the patient demands immediate drug withdrawal.

Special instructions

Use of drug can aggravate a gastroesophageal reflux.

At emergence of the undesirable phenomena against the background of reception of low doses of Kombispazm or lack of therapeutic action after 2 weeks of use, drug should be cancelled.

During use of drug it is necessary to be careful when working, the psychomotor reactions and special attention depending on speed, including at control of vehicles and mechanisms.

Medicinal interaction

Kombispazm can cause converse effect of the means applied to treatment of glaucoma and motility of a digestive tract (Metoclopramidum).

Increase in anticholinergic effect of drug happens at a concomitant use of benzodiazepines, antihistaminic, antipsychotic (Meperidinum) means, monoamine oxidase inhibitors, sympathomimetics, an amantadina, antiarrhytmic drugs І a class, narcotic analgetics, tricyclic antidepressants, nitrites and nitrates.

Strengthening of hepatotoxic effect of paracetamol causes a combination to alcohol, anticonvulsants, barbiturates, rifampicin.

Against the background of the increased intraocular pressure Kombispazm's use along with glucocorticosteroids constitutes danger.

Antacids worsen absorption of anticholinergics, it is necessary to avoid this combination.

Drug suppresses secretion of hydrochloric acid in a stomach, it needs to be considered at treatment of an achlorhydria or a laboratory research of secretion of a stomach.

Terms and storage conditions

To store at a temperature of 15-25 °C. To protect from children.

Period of validity – 2 years.