Lansoprazol of Stada

Lansoprazol of Stada – antiulcerous drug.

Form of release and structure

Dosage form – capsules No. 1: firm, gelatinous, red color; contents – the pellets of spherical shape covered with a kishechnorastvorimy cover of white color (on 10 pieces in planimetric strip or bezjyacheykovy packaging, in a cardboard pack 1, 2 or 3 packagings).

Active ingredient of Lansoprazol of Stada – лансопразол: in 1 capsule – 30 mg.

Auxiliary components: potato starch, sucrose, karmelloza, lactose, povidone (K-30), magnesium carbonate, gipromelloz, sodium hydroxide, polysorbate, diethyl phthalate, methacrylic acid, ethanol, Mannitolum, propylene glycol.

Structure of the capsule: gelatin, crimson, water.

Indications to use

Lansoprazol of Stada is applied to treatment of the following diseases:

• Peptic ulcer of a stomach and 12 perstny guts;
• Stressful ulcers;
• Gastrinoma (Zollingera-Ellison's syndrome);
• The erosive cankers of a stomach and 12 perstny guts which developed as a result of the previous use of non-steroidal anti-inflammatory drugs (NPVS);
• The erosive cankers of a stomach and 12 perstny guts associated with Helicobacter pylori bacterium (complex therapy);
• Erosive and ulcer esophagitis and reflux esophagitis.

Contraindications

Absolute:

• Malignant new growths in digestive tract;
• Age up to 18 years;
• First trimester of pregnancy;
• Lactation;
• Hypersensitivity to drug.

Relative (it is necessary to observe extra care in connection with risk of development of complications):

• Renal/liver failure;
• Advanced age;
• Second and third trimesters of pregnancy.

Route of administration and dosage

Lansoprazol the Stada is accepted inside, swallowing capsules entirely.

The recommended doses depending on indications:

• Aggravation of a peptic ulcer of a 12-perstny gut: on 30 mg a day, in cases of the increased resistance – on 60 mg/days. A course of treatment – 2-4 weeks;
• Aggravation of a peptic ulcer of a stomach: on 30-60 mg/days (to the discretion of the doctor) for 4-8 weeks;
• The digestive tract erosive cankers caused by use of NPVS: on 30 mg/days within 4-8 weeks;
• Eradikation Helicobacter pylori (in combination with antibacterial drugs): on 30 mg 2 times a day a course of 10-14 days;
• Antirecurrent therapy reflux esophagitis: on 30 mg a day, prolonged treatment (up to 6 months);
• The treatment of a peptic ulcer directed to prevention of a recurrence: on 30 mg a day;
• Zollingera-Ellison's syndrome: the dose is selected individually, treatment is carried out until the level of basal secretion less than 10 mmol/hour is reached.

Side effects

The possible side effects caused by drug use:

• Alimentary system: appetite change (decrease or increase), abdominal pain, nausea; seldom – a lock or diarrhea; in individual cases – increase in activity of liver enzymes and level of bilirubin in blood, digestive tract candidiasis, ulcer colitis;
• Central nervous system: headache; seldom – drowsiness, dizziness, an indisposition, alarm, a depression;
• Respiratory system: seldom – rhinitis, pharyngitis, cough, a grippopodobny syndrome, an infection of upper parts of respiratory tracts;
• System of a hemopoiesis: seldom – thrombocytopenia (including with hemorrhagic manifestations), anemia;
• Allergic reactions: rash on skin; in individual cases – a mnogoformny erythema, a photosensitization;
• Others: seldom – an alopecia, a mialgiya.

Special instructions

Before Lansoprazol's appointment Stada it is necessary to exclude existence of malignant process in upper parts of digestive tract as drug can mask its symptoms, thereby complicating timely diagnosis.

Medicinal interaction

At interaction with other medicines лансопразол:

• Slows down removal of medicinal substances which are metabolized by a microsomal oxidation in a liver, including indirect anticoagulants, Phenytoinum and diazepam;
• Reduces clearance of theophylline by 10%;
• Changes pH-dependent absorption of drugs from groups of weak acids (slows down) and the bases (accelerates).

Antiacid means slow down and reduce absorption of a lansoprazol (in need of use of a similar combination they are accepted not later than in 1 hour prior to Lansoprazol's reception by Stada or 1-2 hours later).

Sukralfat reduces bioavailability of a lansoprazol by 30%, for this reason between receptions of these drugs it is necessary to observe 30-minute intervals.

Terms and storage conditions

To store at a temperature up to 25 °C in the dry and protected from light place unavailable to children.

Period of validity – 2 years.