Nemozol

Nemozol – protivogelmintny means.

Form of release and structure

• Suspension for intake: white color (on 20 ml in plastic bottles, 1 bottle in a pack cardboard);
• Tablets, film coated: round, biconvex, almost white or white color (200 mg – on 2 pieces in the blister, 400 mg – on 1 piece in the blister, in a cardboard pack 1 blister);
• Chewable tablets: a kapsulovidny form, oval, biconvex, almost white or white color, with risky on one of the parties (on 1 piece in the blister, 1 blister in a pack cardboard).

Active agent – албендазол, its contents:

• 5 ml of suspension – 100 mg;
• 1 tablet, coated – 200 or 400 mg;
• 1 chewable tablet – 400 mg.

Suspension excipients: potassium a hydrochloride, sodium carboxymethylcellulose, sorbitol solution, polysorbate-80, the benzoic acid, cellulose microcrystallic, sorbic acid, glycerin (глицерол), the water purified ice cream essence, essence the mixed fruit aroma.

Additional components of tablets, film coated:

• Excipients: starch sodium glycollate, methylparaben, sodium lauryl sulfate, starch corn, the talc purified, propylparaben, silicon dioxide colloid, gelatin, magnesium stearate, povidone-30;
• Structure of a cover: tablets of 200 mg – polyethyleneglycol-400, titanium dioxide, sodium the lauryl sulfate, talc purified a gidroksipropilmetiltsellyuloza, and also methylene dichloride and methanol (evaporate during drying); tablets of 400 mg – propylene glycol, titanium dioxide, a gidroksipropilmetiltsellyuloz, and also methylene dichloride and methanol (evaporate during drying).

Excipients of chewable tablets: gelatin, starch sodium glycollate, methylparaben, sodium lauryl sulfate, silicon dioxide colloid, the aspartame, talc purified propylparaben, starch corn, magnesium stearate, povidone-30, citric acid, aroma mint, fragrance pineapple.

Indications to use

• Strongyloidosis;
• Nematodoses (trichuriasis, анкилостомидоз, enterobiosis, necatoriasis, ascaridosis);
• The mixed helminthic invasions;
• Toksokaroz;
• Lambliasis;
• The echinococcosis of a peritoneum, lungs and a liver caused by the larval Echinococcus granulosus form;
• The neurocysticercosis caused by the larval Taenia solium form;
• Ekhinokokkozny cysts (as supportive application at surgical treatment).

Contraindications

Absolute:

• Damage of a retina;
• Pregnancy period;
• Hypersensitivity to components of drug or other derivatives of benzimidazole.

Nemozol it is necessary to apply with care at abnormal liver functions, hemopoiesis disturbance, in the period of a lactation.

Route of administration and dosage

Nemozol it is necessary to accept inside during food.

Average therapeutic doses:

• Nematodoses: adults and children are more senior than 2 years – 20 ml of suspension or 400 mg in tablets once;
• Neurocysticercosis and echinococcosis: patients with body weight from 60 kg – on 400 mg 2 times a day, with body weight to 60 kg – 15 mg/kg/days in 2 receptions. Duration of therapy of neurocysticercosis makes 8-30 days. Treatment of an echinococcosis is carried out by 3 cycles for 28 days with 14-day intervals;
• Lambliasis at children: on 10-15 mg/kg of 1 times a day for 5-7 days;
• Toksokaroz: adults and teenagers are more senior than 14 years with body weight from 60 kg – on 400 mg 2 times a day, adults and teenagers are more senior than 14 years with body weight to 60 kg – on 200 mg 2 times a day, children are younger than 14 years – on 10 mg/kg 2 times a day. Treatment duration – 7-14 days.

Side effects

• Alimentary system: nausea, pain in a stomach, vomiting, an abnormal liver function with weak or moderate increase in activity of transaminases;
• Central nervous system: dizziness, headache, meningeal symptoms;
• System of a hemopoiesis: thrombocytopenia, granulocytopenia, pancytopenia, leukopenia, agranulocytosis;
• Dermatological reactions: itch, skin rash, reversible alopecia;
• Others: fervescence and arterial pressure, allergic reactions, acute renal failure.

Special instructions

During treatment it is necessary to control cellular composition of blood periodically. In case of development of a leukopenia treatment needs to be suspended.

At neurocysticercosis during antitsistovy therapy it is necessary to carry out the corresponding treatment by anticonvulsant drugs and glucocorticosteroids (within the first week for prevention of a hypertensive attack).

At an echinococcosis at the beginning of each 28-day cycle each 2 weeks need to be done blood tests. It is possible to continue Nemozol's use if reduction in the amount of neutrophilic leukocytes and the general maintenance of leukocytes moderate and does not progress.

Medicinal interaction

Cimetidinum and dexamethasone at combined use increase concentration of an albendazol.

Terms and storage conditions

To store at a temperature up to 25 ºС in the unavailable to children, protected from light, dry place.

Period of validity – 3 years.