Orlistat

Orlistat – hypolipidemic means for treatment of obesity.

Pharmacological properties of Orlistat

Active ingredient of drug blocks enzymes which split fats (lipases) in intestines and a stomach. At the same time there is impossible a disintegration of complex fats to fatty acids and monoglycerides, and they are not soaked up, and removed from intestines in an invariable look. Components of digestion of fats are not soaked up in blood at Orlistat's reception, that is in an organism deficit of calories because of what it begins to lose own, postponed in the form of excess of fatty tissue is created.

The accepted dose of drug shows the activity, without having systemic action on all organism. The therapeutic dose of Orlistat blocks digestion about 30% of fats.

According to researches, medicine does not exert negative impact on structure and properties of bile, on the speed of advance of a food lump on a digestive tract or acidity of a gastric juice. The effect of increase in a dose is higher therapeutic it was insignificant. Long reception of Orlistat (3 and more weeks) exerted insignificant impact on balance of some microelements in an organism (magnesium, calcium, zinc, copper, iron, phosphorus).

There is an accurate communication between obesity and existence of cardiovascular diseases, a diabetes mellitus 2 type, cholelithiasis, some forms of cancer. Thanks to decrease in body weight at patients with obesity Orlistat prevents emergence of similar states and mortality from them.

On observations, 24-48 hours later after an initiation of treatment drug in a chair the content of fats increases. After Orlistat's cancellation fats in a chair decrease to norm in 2-3 days.

Drug is almost not soaked up from a digestive tract, in an organism it turns in small amounts into two inactive metabolites, but 83% it are removed with a stake in not changed state. Orlistat has no cancerogenic, embriotoksichesky, mutagen properties.

Release form

According to the instruction Orlistat is issued in capsules of blue color on 120 mg.

Indications to Orlistat's use

Together with a low-calorie diet Orlistat according to the instruction apply at obesity and to decrease in excess body weight. Drug is suitable also for decrease in probability of a repeated increase of weight after its initial reduction. Values of an index of body weight regulate Orlistat's appointment at obesity with IMT of ≥30 kg/sq.m, and also already at figures of IMT of ≥27 kg/sq.m and existence of risk factors (arterial hypertension, a diabetes mellitus, etc.).

Contraindications

Orlistat do not use at hypersensitivity to components drug, at a cholestasia (stagnation of bile) and chronic disturbances of absorption in a small intestine (malabsorption).

Because of insufficient researches on safety and efficiency of drug at the children nursing and pregnant women, its use is limited. With caution it is necessary to take Orlistat in the presence of calcic and oxalic stones in kidneys, a hyperoxaluria in the anamnesis.

Application instruction of Orlistat

According to the instruction drug should be accepted during food no later than in 1 hour after meal. The dosage corresponds to 120 mg 3 times a day. At increase in a therapeutic dosage of Orlistat according to reviews to a certain level also its hypolipidemic effect increases. If for some reason meal is missed, or in it there are no fats, the admission of one dose of drug is allowed.

At patients with the accompanying diabetes mellitus at weight reduction against the background of Orlistat's reception reduction of a dose of glucose-lowering drugs can be required.

Side effects of Orlistat

Orlistat is according to reviews occasionally capable to cause a number of adverse reactions:

• Meteorism;
• Strong desires to defecation, its increase;
• Steatorrhea (increase in fat in Calais);
• Oily allocations from a rectum;
• Pains or discomfort in a stomach;
• Diarrhea;
• Allergic reactions.

If during administration of drug not to keep to a low-calorie diet, then the number of side reactions from a digestive tract will increase.