Pank lavas

Pank lavas – antibacterial agent of a wide range.

Form of release and structure

Dosage form – tablets, film coated: oval form, biconvex, white color; tablets of 500 mg / 125 mg on one of the parties have the squeezed letters "A" and "K" and to risk (on 15 or 20 pieces in the dark glass jars corked by a cover with control of the first opening in a cardboard pack of 1 bank).

Active agents as a part of 1 tablet:

• Amoxicillin (in the form of trihydrate amoxicillin) – 250 or 500 mg;
• Clavulanic acid (in the form of clavulanate potassium) – 125 mg.

Excipients: carboxymethylstarch of sodium, silicon dioxide colloid, magnesium stearate, microcrystallic cellulose.

Structure of the cover covering tablets: propylene glycol, titanium dioxide (E171), gipromelloz.

Indications to use

Pank lavas – the drug intended for treatment of the diseases of infectious and inflammatory character caused by microflora, sensitive to a combination of active ingredients:

• Infections of ENT organs and upper parts of respiratory tracts: pharyngitis, sinusitis (acute and chronic), tonsillitis, otitis (acute and chronic);
• Infections of lower parts of respiratory tracts: pleura empyema, bronchitis and pneumonia (acute and chronic);
• Infections of skin and soft tissues, including phlegmon and wound fevers;
• Infections of bones and joints, including chronic osteomyelitis;
• Dontogenous infections;
• Infections of bilious ways: cholangitis and cholecystitis;
• Infections of urinary tract, including inflammation of an urethra, bladder and kidneys;
• Gynecologic infections, including septic abortion, inflammation of an endometria, appendages of a uterus and uterine tube;
• Infections, sexually transmitted: шанкроид and gonorrhea.

Contraindications

Strict:

• Children's age up to 12 years;
• Infectious mononucleosis, including existence of korepodobny rash;
• Hypersensitivity to drug components, cephalosporins or another beta лактамным to antibiotics.

With care:

• Heavy liver failure;
• Chronic renal failure;
• Digestive tract diseases, including colitis owing to use of penicillin in the anamnesis;
• Pregnancy;
• Lactation.

Route of administration and dosage

Drug is intended for oral administration. Pank lavas it is necessary to accept during food: to swallow of tablets entirely, without chewing and to wash down with enough water.

To adults and teenagers 12 years are more senior (with body weight not less than 40 kg) usually appoint:

• Easy and medium-weight course of infectious process: on 1 tablet of 250 mg / 125 mg 3 times a day;
• Heavy course of an infection: on 1 tablet of 500 mg / 125 mg 3 times a day.

Maximum daily doses:

• Clavulanic acid: for adults – 600 mg, for children – 10 mg/kg;
• Amoxicillin: for adults – 6000 mg, for children – 45 mg/kg.

Therapy course – from 5 to 14 days.

At oral cavity infections usually appoint on 1 tablet 500 mg / 125 mg 2 times a day (bucketed 12 hours) within 5 days.

Dosage at a renal failure:

• Clearance of creatinine of 10-30 ml/minute – on 1 tablet of 500 mg / 125 mg each 12 hours or on 1 tablet of 250 mg / 125 mg 2 times a day (at an easy and medium-weight current);
• Clearance of creatinine less than 10 ml/minute – on 1 tablet of 500 mg / 125 mg each 24 hours or on 1 tablet of 250 mg / 125 mg of 1 times a day (at an easy and medium-weight current).

To patients with an anury increase intervals between administration of drug till 48 and more o'clock.

It is important! 2 tablets of Panklav of 250 mg / 125 to mg are not equivalent to 1 tablet of Panklav of 500 mg / 125 to mg since they contain different amount of clavulanic acid.

Side effects

• Allergic reactions: skin itch, small tortoiseshell, erythematic rashes; seldom – a serum disease, an acute anaphylaxis, a multiformny erythema, a Quincke's disease, acute generalized exanthematous пустулез, a toxic epidermal necrolysis; in isolated cases – an acute anaphylaxis, Stephens-Johnson's syndrome, exfoliative dermatitis;
• From the central nervous system: headache, вертиго; at patients with renal failures and the patients accepting drug in high doses – spasms;
• From digestive tract: stomatitis, increase in activity of hepatic transaminases, abnormal liver function, nausea, diarrhea, vomiting; in isolated cases – pseudomembranous colitis, hepatitis, cholestatic jaundice, increase in level of an alkaline phosphatase;
• Others: vaginitis, development of superinfection, candidiasis of skin and mucous membranes, intersticial nephrite, reversible increase in a prothrombin time.

Special instructions

Patients with hypersensitivity to penicillin have a probability of development of cross allergic reactions with antibiotics of a tsefalosporinovy row.

Due to growth of insensitive microflora development of superinfection is possible. In this case corresponding changes in the scheme of antibacterial therapy are required.

During treatment by Panklav in urine amoxicillin which in high concentration gives false positive reaction to the content of glucose in urine when using a reactant of Benedict or solution of Felinga comes to light. In need of carrying out this research it is recommended to use enzymatic reactions with glucose oxydas.

When performing course therapy it is necessary to control a condition of function of a liver, kidneys and bodies of a hemopoiesis.

Pank lavas do not influence the speed of reactions and ability to concentration of attention.

Medicinal interaction

At simultaneous use of Allopyrinolum the risk of emergence of skin rash increases.

Ascorbic acid increases absorption Panklava; aminoglycosides, antacids, purgatives, a glycosamine – slow down and reduce absorption.

At the combined use of phenylbutazone, Allopyrinolum, diuretics, non-steroidal anti-inflammatory drugs and other drugs blocking canalicular secretion concentration of amoxicillin increases.

At simultaneous use with Panklav bacteriostatic drugs (tetracyclines, macroleads, streptocides, linkozamida, chloramphenicol) have antagonistic effect; bactericidal antibiotics (for example, cephalosporins, aminoglycosides, rifampicin, Vancomycinum, Cycloserinum) – sinergidny action.

Pank lavas increases effect of indirect anticoagulants therefore at purpose of this combination it is necessary to control indicators of coagulability of blood. Drug reduces efficiency of ethinylestradiol, oral contraceptives and medicines in the course of which metabolism paraaminobenzoic acid is formed.

Terms and storage conditions

To store in the place protected from light and moisture with observance of temperature condition 15-25 ºС. To protect from children.

Period of validity – 2 years.