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Propazine

The prices in Internet drugstores:

from 838 rub.

Propazine – antipsychotic drug (neuroleptic).

Form of release and structure

Dosage form – tablets, coated: blue color with a mramornost and impregnations, heterogeneity of coloring of a surface is possible; on cross section 2 layers are visible (in blister strip packagings on 10 pieces, 5 packagings in a pack cardboard; in banks on 50 pieces, in a pack of cardboard 1 bank).

Active agent: Promazinum, in 1 tablet – 25 or 50 mg.

Auxiliary components: potato starch, dextrose (glucose) monohydrate, stearic acid, lactose (sugar milk), talc, sucrose (sugar), dye indigo carmine.

Indications to use

  • Psychotic frustration of any etiology;
  • The acute and chronic psychoses which are followed by crazy frustration, hallucinations, psychomotor excitement;
  • The agitated depressions;
  • Maniacal states;
  • Other mental diseases (neurosises, reactive states, psychopathies) which are followed by fear, tension, sleeplessness, impulsive attacks, excitement;
  • Abstinence syndrome (in narcological practice);
  • Vomiting of various etiology (as an antiemetic).

Depending on indications Propazine can be applied as monodrug or in a combination with other psychotropic drugs.

Contraindications

Absolute:

  • Myxedema;
  • The progressing general diseases of a head and spinal cord;
  • Brain injuries;
  • Oppression of function of the central nervous system and comas of any etiology;
  • Closed-angle glaucoma;
  • Bronchoectatic disease in a decompensation stage;
  • The expressed arterial hypotension;
  • Heart diseases in a decompensation stage (a rheumatic carditis, myocardial dystrophies, heart diseases, etc.);
  • The diseases which are followed by risk of tromboembolic episodes;
  • Prostate hyperplasia;
  • Peptic ulcer of a stomach and 12-perstny gut in the period of an aggravation;
  • Diseases of kidneys, a liver and the hemopoietic bodies with disturbance of functions;
  • Deficit of lactase, intolerance of a galactose, glyukozo-galaktozny malabsorption;
  • Children's age up to 12 years;
  • Pregnancy;
  • Breastfeeding;
  • The increased individual sensitivity to drug components.

With care:

  • Active alcoholism;
  • Epilepsy;
  • Cachexia;
  • Syndrome to Reja;
  • Parkinson's disease;
  • The chronic diseases which are followed by breath disturbance (especially at teenagers 12 years are more senior);
  • Breast cancer;
  • Advanced age.

Route of administration and dosage

Propazine should be accepted inside after food.

Depending on a clinical situation appoint 25-100 mg 2-4 times a day. If expressiveness of antipsychotic action is not enough, the daily dose is gradually increased to 500-1000 mg.

Maintenance dose – 50-150 mg 1-2 times a day.

To teenagers 12 years are more senior appoint 25 mg each 4-6 hours, if necessary adjust a dose.

The weakened and exhausted patients, and also people of advanced age usually need lower initial dose. Further, if there is a need, it is gradually increased.

Side effects

In comparison with often applied aminazine Promazinum is transferred better and less often causes side effects.

In an initiation of treatment can arise: dizziness, drowsiness, accommodation disturbances (an illegibility of visual perception), frustration of a dream, dryness in a mouth, anorexia, a gastralgia, nausea, vomiting, a lock, tachycardia, moderately expressed orthostatic hypotension, a nose congestion, difficulty of an urination.

The following side effects are in rare instances noted: allergic reactions, Quincke's disease, cholestatic jaundice, pigmental retinopathy, disturbance of thermal control (heatstroke), disturbances of a cordial rhythm, skin photosensitization, increase in body weight, galactorrhoea, decrease in a sexual potentiality, priapism, disturbances of a menstrual cycle, melanosis, agranulocytosis, leukopenia, and also phenomena of overdue reaction to external irritations, phenomena of mental indifference and other changes of mentality.

At long use extrapyramidal frustration (the akinetorigidny phenomena, vegetative disturbances, hyperkinesias, an akathisia, a tremor, dyskinesia), in some cases – spasms are possible. As proofreaders of these phenomena use protivoparkinsonichesky drugs. Help to stop to dyskinesia sodium caffeine (subcutaneously 2 ml of 20% of solution) and atropine (subcutaneously 1 ml of 0,1% of solution).

In extremely exceptional cases development of a malignant antipsychotic syndrome is possible.

Special instructions

During treatment it is necessary to control carefully the arterial pressure and pulse, to constantly investigate functions of kidneys and a liver, a picture of peripheral blood, to perform ophthalmologic inspections.

It is necessary to consider that the Propazine applied as an antiemetic can mask the vomiting caused by overdose by other medicines.

Due to the risk of development of a photosensitization during treatment it is not necessary to be exposed to ultra-violet radiation.

During treatment it is forbidden to take alcoholic beverages, to manage motor transport and to carry out potentially dangerous types of works requiring high attention and speed of reactions.

Medicinal interaction

Possible reactions of interaction in case of simultaneous use of Propazine with other medicines:

  • Other substances exerting the oppressing impact on the central nervous system (alcohol and etanolsoderzhashchy drugs, narcotic analgetics, barbiturates, anesthetics, tranquilizers, etc.): the depression of the central nervous system and respiratory depression amplifies;
  • Other drugs causing extrapyramidal reactions: frequency and weight of extrapyramidal disturbances increases;
  • Epinephrinum (adrenaline): the perversion of effect of Epinephrinum is possible that can lead to falling of arterial pressure (such combination should be avoided);
  • Tricyclic antidepressants, monoamine oxidase inhibitors, Maprotilinum: the risk of development of a malignant antipsychotic syndrome increases;
  • Anticonvulsant drugs: the convulsive threshold goes down;
  • Drugs for treatment of a hyperthyroidism: the risk of development of an agranulocytosis increases;
  • Hypotensive drugs: there is a probability of development of the expressed orthostatic hypotension;
  • Ephedrine: its vasoconstrictive action is weakened;
  • Apomorphinum: its emetic effect decreases, the oppressing action on the central nervous system amplifies;
  • The means reducing appetite (except for a fenfluramin): their efficiency decreases;
  • Amphetamine, clonidine, гуанетидин: their action can be suppressed;
  • Bromocriptinum: increase in concentration in a blood plasma of prolactin and decrease in its action is possible;
  • Levodopa: its protivoparkinsonichesky action decreases;
  • Protivoparkinsonichesky means, antacids, lithium drugs: absorption of Promazinum is broken;
  • Prochlorperazine: there can come the long loss of consciousness.

It is necessary to avoid simultaneous use of the antidiarrheal and adsorbing means.

Promazinum strengthens anticholinergic effects of other at the same time used drugs, at the same time its antipsychotic effect can decrease.

Terms and storage conditions

To store in the dry, protected from light place at a temperature up to 25 °C.

Period of validity – 3 years.

The prices in Internet drugstores:

Name of drug

Price

Drugstore

Propazine тбл п / about 25 mg No. 50, Tatkhimfarmpreparata (Kazan)

838 rub.

Сеть московских аптек ИФКNetwork of the Moscow drugstores of IFC
 
 
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