Tamoxifenum

Tamoxifenum concerns to group of antineoplastic means with anti-oestrogenic and nonsteroid action. Drug stops development of tumors, removes inflammatory process and stimulates release of hormones of a hypophysis.

Structure and form of release

The main active ingredient – citrate of Tamoxifenum of 20-40 mg.

Auxiliary components: sodium starch, povidone, cellulose, magnesium stearate, lactose.

Tamoxifenum is issued in the form of tablets on 10, 20 and 40 mg, coated yellow color. The cover of each tablet consists of titanium dioxide, lactose, polyethyleneglycol, a gipromelloza.

Pharmacological properties of Tamoxifenum

Tamoxifenum is antineoplastic drug which stops a hypertrophy of cells, suppresses synthesis of tumoral fabric and slows down process of formation of a tumor.

Tamoxifenum has good responses as effective medicine for prevention of new growths.

Drug from the first reception blocks effect of estrogen for several weeks. Tamoxifenum does not cause the side effects connected with increase in volume of cells and excess growth of fabrics. Drug is quickly soaked up and begins to work actively within 30 minutes.

With disturbances of an ejaculation Tamoxifenum can cause increase in concentration of testosterone and estrogen in blood in men.

After the first reception Tamoxifenum reaches the maximum concentration in blood within 5-7 hours. Drug is metabolized in a liver and forms several metabolites of weak action. Tamoxifenum is brought out of an organism within 15 hours.

Indications to use of Tamoxifenum

Tamoxifenum is appointed for treatment of the following oncological diseases:

• cancer of mammary and chest glands;
• ovarian cancer, prostate;
• melanomas;
• endometrial cancer;
• cancer of kidneys;
• sarcomas.

Tamoxifenum received positive reviews as drug for treatment of tumors of various etiology and nodular educations in soft tissues.

Application instruction of Tamoxifenum

According to the instruction it is necessary to appoint Tamoxifenum after the conducted diagnostic testings which include: gynecologic diagnosis, blood test, definition of indicators of level of cholesterol and hemoglobin, inspection of functioning of a liver and kidneys, survey at the oculist and determination of arterial pressure.

Reception of Tamoxifenum begins with 20 mg 2 times a day, and then the dosage increases to 40 mg 2-3 times a day. The course of treatment lasts from 30 days to 3 months. Treatment is carried out to combinations with the radiation therapy and drugs which are slowing down cell fission process.

According to the instruction Tamoxifenum needs to be accepted inside, washing down with a plentiful amount of water. The daily dose has to be divided into two equal receptions – morning and evening.

Drug can cause an unplanned ovulation therefore during treatment reliable contraceptive drugs are appointed.

During treatment the patients managing vehicles and working at dangerous objects should be careful. Tamoxifenum slows down motor reactions and dulls attention.

Contraindications

Contraindications to purpose of Tamoxifenum are hypersensitivity and intolerance of components of drug, pregnancy and the period of breastfeeding, a leukopenia, a cataract, thrombophlebitis, a renal and liver failure, cardiovascular diseases at heavy stages of a current.

With care medicine is appointed at thrombocytopenia, a thrombocytosis, a hypercalcemia, brain diseases.

Side effects of Tamoxifenum

Tamoxifenum can have the following side effects:

• from system of digestion – nausea, diarrhea, vomiting, dyspepsia, a loss of appetite, a cholestasia, infiltration of a liver, increase in body weight;
• from circulatory system – thrombosis, thrombocytopenia, a leukopenia;
• from the central nervous system – a headache, confusion of consciousness, a faint, dizziness, drowsiness;
• from urinogenital system – cystous tumors, uterine bleedings, painful allocations from a vagina, an itch and burning of generative organs, decrease in a potentiality.

In certain cases Tamoxifenum can cause side effects of allergic character – temperature increase, skin rash, a small tortoiseshell, a bronchospasm, a dermahemia, dermatitis, an alopecia.