Terbinafin

Terbinafin - antifungal means with a broad spectrum of activity of group of allylamines.

Drug is presented in two dosage forms: in the form of tablets for intake and as means for external use.

1 tablet of Terbinafin contains 250 mg of active ingredient of a terbinafin, and also auxiliary elements: starch, microcrystallic cellulose, sodium methylparaben, povidone, sodium lauryl sulfate, magnesium stearate, sodium starch glycollate, colloid silicon dioxide, talc.

Pharmacological action

According to the instruction, Terbinafin is capable to exert medical impact on the wide list of the fungal infections causing diseases of hair, nails, skin, including, dermatophytes (T.rubrum, T.tonsurans, T.mentagrophytes, T.violaceum, T.verrucosum, Microsporum), and also drozhzhepodobny mushrooms of Candida (for example, Pityrosporum, Candida albicans) and multi-colored depriving of activators.

Medical effect of drug happens due to oppression of the skvalenepoksidaza which is in a cellular membrane of a mushroom. Terbinafin's use leads to accumulation of squalene in a cell and to deficit of ergosterol at an early stage of biosynthesis of a cell of the activator that causes her death.

At intake Terbinafin is well soaked up from a GIT, creating high concentration of active ingredient in nails and hair follicles. Within the first weeks of reception тербинафин it is allocated in skin fat, collects in a corneous lipophilic layer in the volume sufficient to provide fungicidal effect of drug. Active ingredient of medicine is removed with urine in the form of metabolites.

Indications to Terbinafin's use

According to the instruction Terbinafin is appointed inside at:

• Onychomycosis - the fungal infection of nails caused by dermatophytes;
• Mycosis of a pilar part of the head;
• Dermatomycosis of shins, pilar part of the head, feet, trunks, and also the barmy infections caused by Candida mushrooms - in cases if expressiveness of an infection causes rationality of peroral therapy.

Terbinafin's use in the form of cream is effective at each of above-mentioned diseases. Besides, according to reviews to Terbinafin it is possible to note that reception of medicine in the form of tablets is not capable to eliminate such fungal infection of skin as multi-colored deprive.

Contraindications

To contraindications to Terbinafin refer hypersensitivity to active ingredient and other components of drug. Also, according to the instruction to Terbinafin it is necessary to refrain from reception of medicine during pregnancy and in the period of a lactation.

At treatment drug recommends to observe precautionary measures. If in the course of therapy the patient has a nausea, lack of appetite, vomiting, pain under the right edge, inexplicable fatigue, and also decoloured by kcal and dark urine, it is necessary to see immediately a doctor for the purpose of confirmation of a hepatic origin of these symptoms and to cancel Terbinafin's reception.

Terbinafin and analogs of drug the people having a renal and liver failure, metabolism diseases, alcoholism, occlusal diseases of extremities and also the children who did not reach 12-year age should take with caution.

So far in responses to Terbinafin it was not reported about existence of malformations of a fruit at medicine use by pregnant women. Nevertheless, it is not recommended to perform treatment by Terbinafin in this situation - because of the insufficient number of researches.

At a concomitant use of Terbinafin and oral contraceptives disturbance of a menstrual cycle is possible.

Side effects

Treatment by Terbinafin, according to patients, causes disturbances of various systems of an organism. From the alimentary system anorexia (refusal of food), nausea, diarrhea, jaundice, a cholestasia, hepatitis are observed. From system of a hemopoiesis - thrombocytopenia, a neutropenia. Besides, Terbinafin's reception can provoke emergence of a headache and local allergic reactions: skin rash, itch, mialgiya, arthralgia, Stephens-Johnson's syndrome, mnogoformny erythema.

According to researches, side effects at Terbinafin's use arise only at 3-5% of patients and the terminations of therapy, as a rule, do not demand.

Analogs

Terbinafin's analogs on active ingredient are such drugs as Atifin, Lamizil, Lamikan, Mikonorm, Onikhon, Terbizil, Terbinoks, Termikon, Ungusan, Qidokan, Ekzivin and some other, possessing similar medical action in relation to dermatomitseta and barmy mushrooms.

Dosage and route of administration of Terbinafin

The single dose of reception of Terbinafin in tablets depends on body weight and makes:

• For children with a body weight less than 20 kg - 62,5 mg;
• From 20-40 kg - 125 mg;
• More than 40 kg - 250 mg.

Terbinafin in the form of means for external use is used for 1-2 weeks, depending on the nature of a disease once a day. Before putting cream affected areas need to be cleared and dried. Terbinafin is rubbed by a thin layer on skin and the sites adjoining to it. When processing an intertrigo between buttocks, in interdigital intervals, under mammary glands the site of application of cream is recommended to be covered with a gauze layer.

Duration of treatment by Terbinafin and analogs of drug depends on disease severity and existence of associated diseases. If within 2 weeks after Terbinafin's reception according to the instruction of improvement did not follow, it is necessary to define sensitivity of the activator to the applied means. At the same time it is worth remembering that early completion of treatment can lead to a recurrence.

This instruction to Terbinafin is not intended for independent treatment. Before administration of drug consult with the doctor.