Triphtazinum

Triphtazinum – the neuroleptic applied to effective treatment of mental disorders and schizophrenia.

Pharmacological action of Triphtazinum

The medicine is the antipsychotic means possessing sedative, antiemetic, protivoikotny, gipomermichesky, cataleptic, hypotensive and slight m-holinoblokiruyushchim action. Triphtazinum in structure is similar to Chlorpromazinum, however has higher activity and is better transferred.

Release form

Triphtazinum is released in the form of tablets, coated, in cellular packagings, in cardboard packs on 10 and 50 pieces or in ampoules on 1 ml of 0,2% of solution on 10 pieces.

Triphtazinum analogs

Triphtazinum analog on active ingredient is Triftazin-Darnitsa. On the mechanism of action and belonging to one pharmacological group carry to Triphtazinum analogs:

• Majeptil;
• Metherazinum;
• Moditenum;
• Etaperazin.

Indications to use of Triphtazinum

The drug Triphtazinum is used in cases of schizophrenia, psychosis, hallucinatory and affective and crazy states, psychomotor vozbuzhdeniye and by vomitings (the central genesis).

Triphtazinum route of administration

According to the instruction Triphtazinum in tablets is applied inside, plentifully washing down with water, or is entered intramusculary in the form of solution. The dosage of means depends on age and a disease. For treatment of an alarming syndrome the tablets Triphtazinum the dose makes 1-2 mg twice a day, the maximum dose makes 6 mg a day, on an extent of no more than 12 weeks. At treatment of psychotic disturbances drug is appointed in number of 2,5-5 mg twice a day, inside, with increase to 15-20 mg a day for 2-3 weeks, the maximum dose makes 40 mg a day. Use of Triphtazinum inside at advanced age and the weakened patient is begun with a smaller initial dose which if necessary can be increased. For children aged from 6 years the dosage of drug makes 1 mg 1-2 times a day with possible gradual increase.

The one-time dosage of the drug Triphtazinum at intramuscular introduction makes 1-2 mg each 4-6 hours, but no more than 10 mg a day. According to the instruction Triphtazinum to people of advanced age, and also the weakened and exhausted patients is appointed in the initial dose reduced twice. For children aged from 6 years the dosage of a medicine makes 1 mg 1-2 times a day.

Contraindications

According to the instruction Triphtazinum is contraindicated to use at:

• Disturbance of secretory function of kidneys;
• Heavy liver failure;
• Oppression of a marrowy hemopoiesis;
• The progressing diseases of a head and spinal cord;
• Craniocereberal injuries;
• Comas of any etiology;
• The expressed oppression of function of the central nervous system;
• Serious cardiovascular illness;
• Hypersensitivity.

The drug Triphtazinum according to the instruction with care is appointed at alcoholism, stenocardia, valve damages of heart, pathological changes of blood, a breast cancer, closed-angle glaucoma, a hyperplasia of a prostate, a liver and renal failure, a peptic ulcer of a stomach and a 12-perstny gut.

Also Triphtazinum according to the instruction with care is applied at Parkinson's disease, epilepsy, a myxedema, a syndrome to Reja, a cachexia and vomiting.

The drug Triphtazinum with care is appointed at advanced age, not appointed to children under 3 years, pregnant women and in the period of a lactation.

Side effects of Triphtazinum

Use of Triphtazinum according to reviews can lead to complications from various systems of an organism in overdose cases, namely:

• Nervous system: sleeplessness, dizziness, drowsiness, akathisia, parkinsonism, late dyskinesia, dystonic extrapyramidal reactions, antipsychotic malignant syndrome, phenomena of mental indifference, change of mentality and overdue reaction to external irritants;
• Endocrine system: a hypoglycemia, a glucosuria, a giperprolaktinemiya, a galactorrhoea, pain or swelling in mammary glands, an amenorrhea, a hyperglycemia, a dysmenorrhea and increase in body weight;
• Urinogenital system: oliguria, decrease in a potentiality, priapism, frigidity, decrease in a libido, disturbance of an ejaculation and ischuria;
• Alimentary system: nausea, loss of appetite, dryness of a mucous membrane of an oral cavity, locks, gastralgia, bulimia, anorexia, vomiting, diarrhea, cholestatic jaundice, hepatitis and paresis of intestines;
• Bodies of a hemopoiesis: leukopenia, thrombocytopenia, pancytopenia, agranulocytosis, eosinophilia and hemolitic anemia;
• Sense bodys: vision disorder (accommodation paresis), phacoscotasmus and corneas, retinopathy and illegibility of visual perception;
• Cardiovascular system: decrease or inversion of a tooth of T, lengthening of an interval of Q-T, disturbance of a cordial rhythm and increase of attacks of stenocardia.

Besides, Triphtazinum according to reviews can cause also other frustration, namely:

• Skin rash;
• Quincke's disease;
• Small tortoiseshell;
• Exfoliative dermatitis;
• Conjunctivas;
• Coloring of skin;
• Photosensitization;
• Decolouration of scleras and cornea;
• Myasthenia;
• Fenilketonuriya.

Also use of Triphtazinum according to reviews can lead to heatstroke development, loss of ability to sweating, confusion of consciousness and false positive tests for pregnancy.

The overdose by a medicine can lead to a malignant antipsychotic syndrome, a lowering of arterial pressure, a hypothermia, tachycardia, a gynecomastia, a coma, a collapse and toxic hepatitis.

Storage conditions

According to the instruction it is necessary to store Triphtazinum in the unavailable to children and protected from light hit dry place, at the room temperature to 25 °C. The period of storage at observance of recommendations makes 4 years.