To Tritatsa

To Tritatsa (tritase) – anti-hypertensive drug, angiotensin-converting enzyme inhibitor.

Pharmacological action to Tritatsa

To Tritatsa – ramiprit active ingredient, at use inside leads to reduction of formation of angiotensin II, accumulation of bradikinin that causes vasodilatation and a lowering of arterial pressure. Ramipril has cardiotyre-tread and endotelioprotektorny effect, increases synthesis of prostaglandins, increases serumal concentration of potassium ions, reduces secretion of Aldosteronum, risk of development of a nephropathy and emergence of a microalbuminuria.

Release form to Tritatsa

To Tritatsa release in the form of oblong tablets with dividing line:

• Light yellow color with an engraving "2,5h" with one and "2,5/HMR" on the other hand in blisters on 14 pieces in cardboard packs which part on 1 tablet 2,5 mg of a ramipril are;
• Light pink color with rare impregnations of lighter and dark shades with an engraving "5h" with one and "5HMP" on the other hand in blisters on 14 pieces in cardboard packs which part on 1 tablet 5 mg of a ramipril are;
• White or almost white color with an engraving of "HMO/HMO" on one party in blisters on 14 pieces in cardboard packs which part on 1 tablet 10 mg of a ramipril are.

Analogs Tritatsa

Analogs Tritatsa on active ingredient are:

• Amprilan;
• Вазолонг;
• Dilaprel;
• Piramil;
• Ramigamma;
• Hartil.

On the mechanism of action and belonging to one pharmacological group carry to analogs Tritatsa:

• Angiopril-25;
• Blokordil;
• Vero-Kaptopril;
• Golten;
• Dapril;
• Zoniksem;
• Инхибейс;
• Kapoten;
• Liten;
• Моэкс 15;
• Prenessa;
• Renitek.

Indications to use to Tritatsa

According to the instruction to Tritatsa appoint at:

• Essential giperteziya;
• Combination therapy of chronic heart failure (in a combination with diuretics);
• Diabetic or not diabetic nephropathy;
• The confirmed coronary heart disease;
• Occlusal damages of peripheral arteries;
• Diabetes mellitus with accessory factors of risk;
• The heart failure developing during the first several days after an acute myocardial infarction.

Route of administration to Tritatsa

According to the instruction to Tritatsa accept inside, irrespective of meal, plentifully washing down with water. Duration of treatment and a dosage depend on a disease and are appointed the doctor individually.

Contraindications

According to the instruction it is contraindicated to Tritatsa to apply at:

• Quincke's diseases;
• Hemodynamically significant stenosis of renal arteries, aortal or mitral valves;
• Arterial hypotension and states;
• Unstable indicators of a hemodynamics;
• Hemodialysis;
• Subaortic hypertrophic stenosis;
• Primary hyper aldosteronism;
• The expressed renal failure;
• Pregnancies and in the period of a lactation;
• Nephropathy;
• Chronic heart failure in a decompensation stage;
• To Afereza of lipoproteins of low density;
• The hyposensibilizing therapy;
• Hypersensitivity to components of tablets to Tritatsa;
• Acute stage of a myocardial infarction (heavy heart failure, unstable stenocardia, disturbances of a cordial rhythm and pulmonary heart).

Also according to the instruction to Tritatsa with care appoint in a case:

• State at which the lowering of arterial pressure is especially dangerous;
• The states which are followed by increase in activity of hormonal system;
• The previous reception of diuretics;
• Disturbances of water and electrolytic balance;
• Abnormal liver functions;
• The cirrhosis which is followed by hypostases and ascites;
• Transplantations of kidneys;
• General diseases of connecting fabric;
• Diabetes mellitus;
• Hyperpotassemias.

Drug is not intended for use to children aged up to 18 years and with care is appointed to elderly people.

Side effects to Tritatsa

Use to Tritatsa according to reviews can lead to complications from various systems of an organism in overdose cases. From organs of sight to Tritatsa according to reviews most often causes conjunctivitis and visual frustration, acoustic organs – a ring in ears or a hearing disorder. Besides, the overdose of medicine can cause and other frustration, namely:

• Cardiovascular system (lowering of arterial pressure, orthostatic hypotension, syncopal states, myocardium ischemia, tachycardia, arrhythmia, peripheral hypostases, vasculitis, Reynaud's syndrome, disturbances of blood circulation and heartbeat);
• The central nervous system (a headache, dizzinesses, an ageusia, a dysgeusia, the suppressed mood, alarm, nervousness, sleep disorders, attention and psychomotor reactions, a tremor, brain ischemia, paresthesia and a parosmiya);
• Respiratory system (dry cough, bronchitis, asthma, sinusitis, bronchospasm and congestion of a nose);
• Alimentary system (inflammation of a stomach and intestines, dryness of a mucous membrane of an oral cavity, digestive disturbance, dyspepsia, diarrhea, nausea, vomiting, pancreatitis, gastritis, abdominal pain, lock, glossitis, aphthous stomatitis);
• Gepatobiliarny system (increase in concentration of the conjugated bilirubin in a blood plasma and activity of liver enzymes, cholestatic jaundice, hepatocellular defeats, an acute liver failure, cytolytic and cholestatic hepatitis);
• Kidneys and urinary tract (a renal failure and a renal failure, increase in urination, strengthening of a proteinuria, increase in concentration of urea and creatinine in blood);
• Mammary glands and reproductive system (impotence, decrease libido and gynecomastia);
• Systems of a hemopoiesis (an eosinophilia, a leukopenia, decrease in concentration of hemoglobin and quantity of erythrocytes in peripheral blood, thrombocytopenia, oppression of a marrowy hemopoiesis and hemolitic anemia);
• Mucous membranes and skin (skin rash, Quincke's diseases, skin itch, hyperhidrosis, exfoliative dermatitis, small tortoiseshell, onycholysis, reaction of a photosensitization, Stephen-Johnson's syndrome, psoriazopodobny dermatitis, toxic epidermal necrolysis, pempigus, alopecia, mnogoformny eritrema, strengthening of a course of psoriasis, pemfigoidny and lichenoid ekzatema or enanty);
• Musculoskeletal system (muscular spasms, a mialgiya, an arthralgia, disturbances of laboratory indicators, food and a metabolism, increase in potassium concentration in blood, anorexia, a loss of appetite and concentration of sodium in blood);
• Immune system (anaphylactoid and anaphylactic reactions, increase in concentration of antinuclear antibodies).

Also use to Tritatsa according to reviews can lead to a stethalgia, feeling of fatigue, temperature increase and an adynamy.

Storage conditions

According to the instruction Tritatsa needs to store in the place unavailable to children, at the room temperature up to 25 °C. The period of storage of a medicine makes 5 years.