Indications to use

Reflux esophagitis;
Hyperacid gastritis;
Gastroduodenit;
Peptic ulcer of a stomach and duodenum in an aggravation phase;
Symptomatic ulcers;
Reflux gastritis;
The stressful ulcers and erosive cankers of digestive tract connected with reception of non-steroidal anti-inflammatory drugs;
Medicinal ulcer;
Hyperphosphatemia at the patients with uraemia who are on a hemodialysis;
Heartburn.

Contraindications

Heavy renal failures;
Bleedings from digestive tract;
Impassability or dysphagy of digestive tract;
Hypersensitivity to drug components.

The feeding and pregnant women should take drug with caution.

Route of administration and dosage

Venter the adult standardly appoint inside 0,5-1 g, frequency rate of reception – 4 times a day. Also it is possible to accept drug on 1 g 2 times a day (in the morning and in the evening) or on 2 g 2 times a day in 1 hour prior to food and before going to bed.

The maximum daily dose – 12 g. The average duration of therapy of a peptic ulcer – 4-6 weeks, in case of need – up to 12 weeks.

At patients with a hyperphosphatemia at decrease in concentration of phosphates in plasma the dosage can be reduced.

To children drug is appointed on 0,5 g by 4 times a day.

Tablets can be swallowed entirely, washing down with liquid, or also, as well as granules to dissolve before inclusion in 1/2 glasses of water.

Side effects

At Venter's use the following side effects are possible:

Central nervous system: dizziness, drowsiness, headache;
Alimentary system: diarrhea, locks, dryness in a mouth, nausea, a gastralgia;
Dermatological reactions: urticaria, rash, skin itch;
Others: pain in a waist.

Special instructions

In need of simultaneous use of Venter with antacids, they should be taken for half an hour to or in half an hour after administration of drug.

Emergence of spasms and drowsiness can indicate toxic influence of aluminum.

At a renal failure it is necessary to control concentration of phosphates and aluminum in serum.

Short therapy can lead to full scarring of an ulcer, but Venter's reception does not change weight and frequency of the recurrence of a peptic ulcer arising after scarring.

Medicinal interaction

At simultaneous use of Venter:

Decrease in anticoagulating activity of indirect anticoagulants is possible (including warfarin);
Absorption of antimicrobic means of derivatives of a ftorkhinolon, digoxin, tetracycline, Sulpiridum, Phenytoinum, and also amitriptyline decreases that can lead to reduction of clinical performance of the last;
Considerably efficiency of left thyroxine decreases;
Perhaps some reduction of bioavailability of ranitidine, Cimetidinum, roksatidin;
Concentration of quinidine in a blood plasma decreases;
Minor changes of pharmacokinetics of theophylline are observed. Also perhaps considerable decrease in absorption of theophylline from dosage forms with the slowed-down release;
Perhaps insignificant reduction of absorption of a flukonazol and ketokonazol.

Believe that at combined use formation of chelate complexes with sukralfaty Tobramycinum, colistin of sulfate, B Amphotericinum is possible that can lead to decrease in their antimicrobic activity.