Nitrogen protoxide – narcotic drug for inhalation anesthesia.
Dosage form – the gas compressed: colourless, can have a slight specific smell, with the non-inflammable, but sustaining combustion property (on 6,2 kg in metal cylinders with a capacity of 10 l).
Active agent – a dinitrogene oxide, in 1 cylinder – 6,2 kg.
Use of Nitrogen of protoxide is shown:
With care drug is used at patients with a craniocereberal injury, an intracranial tumor, increase in intracranial pressure in the anamnesis.
In case of need uses during pregnancy drug appoint in small concentration (in a proportion 1:1 to oxygen) to small time (during 2-3 breaths).
Nitrogen protoxide is applied in the form of inhalation in a combination with oxygen and other anesthetics by means of the special equipment for a gas anesthesia in stationary conditions.
Usually anesthesia begin 70-80% of a dinitrogene of oxide and 20-30% of oxygen with mix with contents.
The recommended concentration of a dinitrogene of oxide:
For children concentration of drug are selected individually, at the same time the content of oxygen in mix has to make 30% and more. After end of anesthesia it is necessary to continue inhalation supply of oxygen within 5 minutes for prevention of a hypoxia.
Inhalation anesthesia is carried out against the background of premedication. For the purpose of the prevention of nausea and vomiting, for decrease in contagious excitation and strengthening of action intramuscular introduction of 2-3 ml of 0,25% of solution of Droperidolum (5-7,5 mg), 1-2 ml of 0,5% of solution of diazepam (5-10 mg) is shown.
Use of Nitrogen of protoxide can cause side effects in the form of bradycardia, supraventricular arrhythmias, a circulatory unefficiency – during introduction of the patient to a condition of the general anesthesia.
Undesirable effects after an exit from an anesthesia can become: drowsiness, nausea, vomiting, diffusion hypoxia, confusion of consciousness, feeling of alarm, excitement, nervousness, hallucinations, motive excitement. Long use (2 and more than a day) can lead to respiratory depression, dysfunction of marrow (a leukopenia, pancytopenias), to cause a postoperative fever and hyper thermal crisis.
Use of drug needs to be accompanied with control of arterial pressure, heart rate (HR), a cordial rhythm, and also to watch a condition of gas exchange and breath, body temperature of the patient. During an anesthesia it is recommended to pump out periodically gas from a cuff of an endotracheal tube.
Use of Nitrogen of protoxide is shown at treatment of children of chest and advanced age. It is impossible to appoint drug newborn.
The long contact with drug at medical personnel increases risk of development of a leukopenia.
Certain concentration of mix with cyclopropane, ether, Aether chloratus are explosive.
Patients with an alcoholism require purpose of high concentration of a dinitrogene of oxide.
Drug is not used at control of vehicles and mechanisms.
At simultaneous use of Nitrogen of protoxide:
At a combination drug strengthens effects of diazoxide, ganglioblokator, diuretics, derivative coumarin and the indandion, means oppressing a nervous system and breath.
To store at a temperature up to 25 °C. To protect from children.
Period of validity – 5 years.
Even if heart of the person does not fight, then he all the same can live during a long period, as the Norwegian fisherman Jan Revsdal showed us. Its "motor" stopped for 4 hours after the fisherman got lost and fell asleep in snow.
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