Adrenaline – alpha and beta-adrenergic agonist with hypertensive, broncholitic, antiallergic action.
For injections contains in 1 ml of solution:
For topical administration contains in 1 ml of solution:
Solution for injections
Besides, use of drug is shown as a vasoconstrictor for a stop of bleeding and lengthening of the period of effect of local anesthetics.
Solution for topical administration of 0,1%
Solution is applied to a bleeding stop from superficial vessels of mucous membranes (including a gingiva) also by skin.
In addition contraindications to use of solution for injections:
All above-mentioned contraindications are relative at states, life-threatening the patient.
With care it is necessary to appoint solution for injections at a hyperthyroidism and the patient at advanced age.
For prevention of arrhythmias drug is recommended to be used in combination with beta adrenoblockers.
With care appoint Adrenaline in the form of solution for topical administration sick with a metabolic acidosis, a hypoxia, a hypercapnia, fibrillation of auricles, pulmonary hypertensia, ventricular arrhythmia, a hypovolemia, a myocardial infarction, shock of not allergic genesis (including cardiogenic, hemorrhagic, traumatic), occlusal diseases of vessels (including atherosclerosis, an arterial embolism, a Thrombangiitis obliterans, a diabetic endarteritis, cold injuries, a Raynaud's disease in the anamnesis), a thyrotoxicosis, a prostatauxe, closed-angle glaucoma, a diabetes mellitus, cerebral atherosclerosis, a convulsive syndrome, Parkinson's disease; at simultaneous use for the general anesthesia of inhalation drugs (Ftorotanum, chloroform, cyclopropane), at advanced or children's age.
Solution for topical administration
Solution is applied locally.
At a stop of bleeding it is necessary to put the tampon moistened in solution to a wound.
Solution for injections
Solution is intended for intramuscular (in oil), hypodermic (п / to), intravenous (in/in) drop or jet introduction.
The recommended dosing mode for adults:
The recommended dosing for children:
Solution for injections Adrenaline can also be used locally, for a stop of bleedings, having put the tampon moistened in solution to a wound surface.
In addition, owing to use of solution for injections:
It is necessary to report about emergence of the specified or other undesirable effects to the doctor.
Accidentally entered into Epinephrinum can sharply raise the ABP.
Against the background of increase in the ABP at administration of drug development of attacks of stenocardia is possible. Action of Epinephrinum can cause reduction of a diuresis.
Infusion should be carried out to large (preferably central) vein, using the device for regulation of rate of administering of drug.
Endocardiac introduction at an asystolia is applied in case of unavailability of other ways as there is a risk of a cardiac tamponade and pheumothorax.
Treatment is recommended to be accompanied with determination of level of maintenance of potassium ions in blood serum, measurement of the ABP, minute volume of blood circulation, pulmonary pressure, jamming pressure in pulmonary capillaries, a diuresis, the central venous pressure, carrying out an electrocardiography. Use of high doses at a myocardial infarction can strengthen ischemia because of increase in oxygen requirement.
During treatment of patients with a diabetes mellitus increase in a dose of derivatives of sulphonylurea and insulin as Adrenalin increases a glycemia is required.
Absorption and final concentration of Epinephrinum in plasma at endotracheal introduction can be unpredictable.
At depressed cases use of drug does not replace transfusion of blood-substituting liquids, saline solutions, blood or plasma.
Prolonged use of Epinephrinum causes narrowing of peripheral vessels, risk of development of a necrosis or gangrene.
It is not recommended to use drug at the time of delivery for increase in the ABP, introduction of high doses for weakening of reduction of a uterus can become the reason of a long atony of a uterus with bleeding.
Use of Epinephrinum at a cardiac standstill at children is allowed on condition of respect for care.
Drug withdrawal should be carried out by a gradual dose decline not to allow development of arterial hypotension.
Adrenaline easily collapses the alkylating means and oxidizers, including bromides, chlorides, iron salts, nitrites, peroxides.
At emergence of a deposit or discoloration of solution (pinkish or brown) drug is not suitable for use. Unused drug is subject to utilization.
The doctor solves a question of the admission of the patient to control of vehicles and mechanisms individually.
To store at a temperature up to 15 °C in the place protected from light. To protect from children.
Period of validity – 3 years.
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