Alprazolam

Alprazolam – medicine of antidepressive, somnolent and moderate anticonvulsant action.

Form of release and structure

Means is released in tablets a dosage of 0,25 mg and 1 mg, on 50 pieces in packaging.

Indications to use

According to the instruction, Alprazolam apply at:

• The alarming states and neurosises which are followed by sense of danger or concerns, deterioration in a dream, and also somatic disturbances;
• Neurotic reactive depressions which are followed by decrease in mood, sleeplessness, loss of interest to surrounding and a loss of appetite;
• The mixed alarming depressions;
• Panic frustration with symptoms of a phobia and without them;
• The alarming states and neurotic depressions which developed against the background of somatopathies.

Contraindications

According to the instruction, Alprazolam it is contraindicated to apply at:

• Heavy depression;
• To closed-angle glaucoma;
• Shock;
• Acute alcoholic poisonings, hypnotic drugs and psychotropic drugs, and also opioid analgetics;
• Chronic obstructive respiratory diseases with initial manifestations of respiratory insufficiency;
• Myasthenias;
• Acute respiratory insufficiency;
• Hypersensitivity to benzodiazepines or other components of Alprazolam.

Alprazolam's use during pregnancy is contraindicated because of the toxic impact made on a fruit.

Active ingredient of drug is emitted with breast milk and can negatively affect the newborn therefore for the period of medicine reception breastfeeding needs to be interrupted.

Alprazolam do not appoint to persons 18 years are younger.

During treatment it is contraindicated to take alcohol.

At renal failures or a liver drug should be used with the increased care.

Route of administration and dosage

According to the instruction, Alprazolam is recommended to accept in minimal effective doses. The initial dosage makes from 250 to 500 mkg to three times a day. In need of it it is possible to raise gradually to 4,5 mg a day. At the weakened organism, and also at advanced age the initial dose should not exceed 500-750 mkg a day.

Side effects

Most often side effects arise in an initiation of treatment and are shown as feeling of fatigue, drowsiness, dizziness, an ataxy, decline in the ability to concentration of attention, instability of gait, a disorientation, and also delay of mental and motor reactions.

In certain cases Alprazolam's use can cause the following by-effects:

• From TsNS: headache, depression, lacks of coordination of movements, aggressive flashes, euphoria, uneasiness and sleeplessness, dystonic extrapyramidal reactions, decrease in memory, hallucination, confusion of consciousness, psychomotor excitement, tremor, depression of mood, weakness, myasthenia, dysarthtia, irrational fear, muscular spasm;
• From the alimentary system: a loss of appetite, nausea, dryness in a mouth or hypersalivation, heartburn, a lock or diarrhea, vomiting, disturbance of functions of a liver, jaundice;
• From an urinary system: incontience or ischuria, disturbance of functions of kidneys;
• From cardiovascular system: lowering of arterial pressure and tachycardia;
• From system of a hemopoiesis: neutropenia, leukopenia, agranulocytosis, anemia, thrombocytopenia;
• Allergic reactions: skin rash and itch;
• From endocrine system: disturbances of a libido, change of body weight and disturbance of a menstrual cycle.

Special instructions

At treatment it is necessary to consider that prolonged use of Alprazolam in high doses can develop accustoming. Cancellation of medicine needs to be carried out gradually. It is recommended to lower a dose by 500 mkg in reception not more often than three times a day. In certain cases slower drug withdrawal is required. Can lead the sharp termination of reception of Alprazolam to a withdrawal which is shown in the form of sleeplessness, the strengthened sweating, spasms, a tremor, and also spasms of skeletal muscles.

At treatment of endogenous depressions drug can be used along with antidepressants.

Alprazolam's reception with psychotropic and anticonvulsants can strengthen negative effect of drug on the central nervous system.

It is necessary to be careful at simultaneous use of medicine with blockers of histamine H2 receptors, antibiotics from group of macroleads, other tranquilizers and digoxin.

Analogs

The following drugs belong to structural analogs of Alprazolam: Alzolam, Heleks, Heleks of WEDNESDAY, Zolomaks.

Conditions and periods of storage

Alprazolam it is necessary to store in the place protected from impact of a sunlight at air temperature no more than 30 °C.

The period of validity of drug makes 5 years of date of production.