The prices in Internet drugstores:
from 2174 rub.
Alzepil – the selection inhibitor of acetylcholinesterase of a brain applied to treatment of Alzheimer's disease.
Dosage form – tablets, film coated: round, convex from two parties, almost white or white color, on one of the parties an engraving of "E381" (a tablet of 5 mg) or "E382" (a tablet of 10 mg), almost inodorous (on 14 таб. in the blister, in a cardboard pack 2 or 4 blisters).
Contains in 1 tablet of Alzepil:
Alzepil – drug for symptomatic therapy of dementia of altsgeymerovsky type of any severity.
Relative (Alzepil take with caution):
Alzepil it is necessary to accept in 1 times a day, before going to bed.
Initial dose – 5 mg. Duration of its reception makes 4 weeks then if necessary the dose is raised to 10 mg/days in 1 reception.
The maintenance therapy can be carried out until the therapeutic effect of drug remains (it should be estimated regularly). If Alzepil ceases to act, it needs to be cancelled.
Patients with abnormal liver functions (regardless of severity) do not need dose adjustment as these states do not exert impact on clearance of donepezil.
* At patients with faints and convulsive attacks cordial blockade is possible.
There are no data on development of a withdrawal in case of the sharp termination of reception of Alzepil, gradual reduction of therapeutic effect of drug is observed.
In need of carrying out operation under the general anesthesia it is necessary to consider that donepezil can increase expressiveness of neuromuscular blockade which is caused by the depolarizing muscle relaxants.
Alzepil can have vagotonic effect on heart rate (in particular, to cause bradycardia). The probability of such effect is important for patients with a sick sinus syndrome and other disturbances of supraventricular conductivity (for example, atrioventricular or sinuatrial block).
Inhibitors of cholinesterase are, presumably, capable to cause generalized spasms to some extent. However convulsive activity can also be manifestation and a basic disease.
Drug is capable to strengthen secretion of hydrochloric acid in a stomach therefore special observation during treatment is required to patients who have a risk of development of stomach ulcer and a 12-perstny gut.
Though in clinical trials this effect did not meet, it is necessary to consider probability of development of an ischuria.
Alzepil can cause dizziness, fatigue and myotonia, especially at the beginning of therapy and at increase in a dose. Besides, the disease concerning which drug is used can be followed by disturbance of speed of reactions and abilities to concentration of attention. For this reason the question of a possibility of driving and performance of potentially dangerous types of works has to be solved individually with the doctor.
Alzepil it is necessary to apply with care along with CYP3A4 and CYP2D6 inhibitors (for example, quinidine, ketokonazoly, itrakonazoly, erythromycin, fluoxetine) as they suppress donepezil metabolism.
Inductors of isoenzymes, such as ethanol, Phenytoinum, rifampicin and carbamazepine, can promote decrease in concentration of donepezil in a blood plasma. As extent of such action is unknown, it is necessary to apply similar combinations also with care.
Donepezil exerts impact on effects of drugs which have anticholinergic activity.
At simultaneous use of agonists of holinoretseptor, quarternary anticholinergic drugs (for example, a bromide glikopirroniya) atypical changes of arterial pressure and heart rate are possible.
In case of the combined use donepezil can strengthen effect of succinylcholine of bromide and other muscle relaxants, agonists of holinoretseptor, the beta adrenoblockers exerting impact on conductivity of heart.
To store at a temperature which is not exceeding 30 °C in the place, unavailable to children.
Period of validity – 5 years.
Name of drug
Alzepil тбл п/пл/о 5 mg No. 28, Egis
Alzepil of a tablet 5 of mg of 28 pieces
Alzepil of a tablet 10 of mg of 28 pieces
Each person has not only unique fingerprints, but also language.
Cystitis, or inflammation of a mucous membrane of a bladder, this very widespread disease, which, owing to some persons...Section: Articles about health
All like to sing. Small children with pleasure are engaged in a vocal, not especially thinking of hit in a melody. Adults most often hesitate, being afraid to show lack of talents in this area, and it is vain: singing is very useful for health....Section: Articles about health
Sooner or later hair turn gray at all. Many people try to hide these changes, returning natural color of the hair by means of coloring, or considerably changing it for the purpose of creation of absolutely new image. All know that the gray hair is a sign of the coming old age, so, it is necessary to get rid of it....Section: Articles about health
About influence of fasting days on an organism it is told much – both about advantages, and about shortcomings. It is considered that fasting day...Section: Articles about health
One of the major chemical processes happening in a human body are oxidation reactions. They go with participation of fats and carbohydrates which we receive from food, and the oxygen getting to us from air. A main goal of such reactions is it is received...Section: Articles about health
There is a lot of fans of beer in our country. Statistically, on each average Russian (including women and children) in a year about 60 liters of this drink are consumed. It is not a lot of, as in the Czech Republic or Germany, but figure all the same impressive. There is nothing to rejoice here: despite assurances of producers that beer is absolutely harmless, effects of its active consumption cannot be considered positive in any way. Here only part of that negative impact, which popular нап...Section: Articles about health
Eyes – unique body on the structure thanks to which the person obtains about 80% of information on the world around: about a form...Section: Articles about health
Aging — natural and inevitable process. Over time our skin loses elasticity, on it saggings are formed, the face form loses former clearness. The procedure of nitevy lifting (nitevy tightening) can successfully solve this problem. In order that it is better познако...Section: Articles about health
We present to yours the TOP of the medicamentous means exerting the stimulating impact on a potentiality, i.e. on ability of the man to commission of sexual intercourse. At once it is necessary to tell that not always disturbances of erectile function can be eliminated with reception of this or that drug. The reasons of decrease in a potentiality there can be a set, from banal overfatigue before tumoral process in a small basin therefore if the man faces similar problems too often, it should turn...Section: Articles about health
A little more than a century ago goat milk was a traditional food stuff of most of Russians. Unfortunately, today on tables...Section: Articles about health
Olive oil – the product capable to make a powerful contribution to health of the person if it includes it in the diet. The rich vitamin composition of oil does it by a product number one from many diseases including from deadly. Only two tablespoons...Section: Articles about health
The nature does not stand stagnation and monotony. It is known that tissues of a human body atrophy if do not receive necessary loadings. It fully belongs also to a cerebral cortex: when it is not given full-time job, it begins to function worse. As a result memory decreases, the person becomes less bright, acquires information more slowly, hardly switches from one thought to another. There are problems at work, difficulties with communication and career development. These it is unpleasant...Section: Articles about health
People know that thermal sources have salutary force long ago. Treatment by natural waters is one and...Section: Articles about health
Cold, puffiness of a nose, itch, the watering eyes - characteristic symptoms of the allergic rhinitis resulting from hit of allergens (pollen, house dust, hair of animals, etc.) on a mucous membrane of a nose. Unpleasant feelings often deliver беспоко...Section: Articles about health
The trophic ulcer is not an independent disease. This heavy complication arising owing to a thermal injury (a burn or a frostbite), chronic pathologies of arteries or veins of the lower extremities, a diabetes mellitus, and also some defeats of connecting fabric, absorbent vessels, skin or nervous trunks. Pathology is shown in the form of not healing wound located on the internal surface of a shin, a foot sole, a heel or toes....Section: Articles about health
Modern footwear is extremely various. It stopped being only protection for legs long ago. Today shoes, boots, barefoot persons in...Section: Articles about health
Frosty air, fresh wind and easy snowball at most of Russians are associated with cheerfulness, health and cheerful entertainments on which our winter is so generous. But, unfortunately, cold season sometimes brings also troubles with health. It is not about a season...Section: Articles about health
You heard that laughter prolongs life? Researchers did not manage to establish longevity direct link with sincere fun yet, but several facts confirming beneficial influence of risibility on the state of health are clinically proved....Section: Articles about health
Diapers for adults – individual one-time means of hygiene which in some situations is irreplaceable, and from such situats...Section: Articles about health
The way of life of people promptly changes from year to year: if about ten years ago the personal computer was not in each family, then today already very few people do without this device. Certainly, and children master the computer at full speed: they not only I play...Section: Articles about health
Each woman has preferences in the field of use of those goods which help us to look good, feel young and effective. Besides: selection process of favourite perfume, shampoo or decorative cosmetics already lightens the mood and serves as a peculiar stress medicine. Happens very offensively when the acquired perfumery and cosmetic products not only do not meet our expectations, but also becomes the reason of problems with health. Sources неприятн...Section: Articles about health
The majority of gynecologic diseases prove three main signs, each of which speaks about need to the visa...Section: Articles about health
Herpes simplex of the first type (the infectious disease which is shown periodic bubble rashes on lips is called) – one of the most widespread illnesses. Statistically, only 5% of inhabitants of our planet are unreceptive to its activator, and...Section: Articles about health
Is told about advantage of domestic animals for development of the child much. But many parents nevertheless do not hurry to bring pets as are afraid that they can do harm to health of children. What troubles can really trap kids and how to make joint life of a family and domestic animals comfortable and safe?...Section: Articles about health
Stability of a hormonal background is one of the most important conditions of preservation of health of the woman. At the same time endocrine system –...Section: Articles about health
The stroke is one of the most widespread diseases of the person, annually in the world about 6 million cases of this pathology are registered. According to medical statistics, strokes occur almost three times more often than myocardial infarctions. Disease otno...Section: Articles about health
There is an opinion that at low temperatures safety of products is ensured longer and better thanks to what the refrigerator is considered the most suitable place for storage of food. In most cases it is fair, however there is a number of products for which low temperatures – the main reason of their premature damage. Storage in the refrigerator leads to their bystry rotting, emergence of a mold, is followed by loss of vitamins and tastes. What products it is better to remove...Section: Articles about health