Aminoveins

Aminoveins – the medicine for parenteral food applied to completion of deficit of amino acids.

Form of release and structure

Dosage form of release of Aminoven – solution for infusions of 5%, 10% or 15%: slightly opalescent or transparent, slightly yellowish or colourless (in bottles on 500 or 1000 ml, on 6 or 10 bottles in a cardboard pack).

Active agents as a part of 1 l of infusion solution (5%/10%/15%):

• L-leucine: 3,7/7,4/8,9 g;
• L-izoleytsin: 2,5/5/5,2 g;
• L-methionine: 2,15/4,3/3,8 g;
• L-lysine acetate: 4,655/9,31/15,66 g (corresponds to a L-lysine – 3,3/6,6/11,1 g);
• L-threonine: 2,2/4,4/8,6 g;
• L-phenylalanine: 2,55/5,1/5,5 g;
• L-valine: 3,1/6,2/5,5 g;
• L-tryptophane: 1/2/1,6 g;
• L-histidine: 1,5/3/7,3 g;
• L-arginine: 6/12/20;
• L-alanine: 7/14/25;
• L-tyrosine: 0,2/0,4/0,4 g;
• L-serine: 3,25/6,5/9,6 g;
• L-proline: 5,6/11,2/17 g;
• Taurine: 0,5/1/2 g;
• Glycine: 5,5/11/18,5 g.

Additional components (5%/10%/15%): acetic ice acid – 2,2-2,8/4,7-5,7/4,45 g, malic acid – 0/0/4,9-6,1 g, water for injections (for all types of solutions) – to 1 l.

Indicators (5%/10%/15%): the general nitrogen – 8,1/16,2/25,7 g/l, the general concentration of amino acids – 50/100/150 g/l, energy value – 840/1580/2520 kJ/l (200/400/600 kcal/l), theoretical osmolarity – 495/990/1505 ¼«ß¼«½ý/l, titrable acidity – 12/22/44 mmol of NaOH/l, a hydrogen indicator (рН) – 5,5-6,3/5,5-6,3/5,5-6,3.

Indications to use

• Parenteral food (full or partial). Aminoveins, as a rule, apply in combination with enough energy sources (glucose, fatty emulsions);
• Loss of proteins when enteral/peroral food is impossible, contraindicated or is not enough (treatment and prevention).

Contraindications

• Metabolic acidosis;
• Disturbance of metabolism of amino acids;
• Renal failure in cases if there is no hemodialysis or haemo filtering;
• Dekompensirovanny heart failure;
• Liver failure in a heavy current;
• Overload liquid;
• Hypoxia;
• Shock;
• Age up to 2 years;
• Hypersensitivity to drug components.

To women during pregnancy and a lactation Aminoven's introduction perhaps after advantage ratio assessment with risk.

Route of administration and dosage

Aminoveins it is intended for intravenous administration.

5%/10% enter solutions into a peripheral or central vein (the choice decides by final osmolarity at the combined introduction on other solutions); 15% solution need to be entered only into the central veins.

Time of introduction of infusion depends on indications and the need for amino acids.

Adults
The average/maximum dose in day:

• 5%: 16-20 ml/kg (800-1000 mg/kg that corresponds to 1120-1400 ml for patients weighing 70 kg)/20 ml/kg (1000 mg/kg that corresponds to 1400 ml for patients weighing 70 kg);
• 10%: 10-20 ml/kg (1000-2000 mg/kg that corresponds to 700-1400 ml for patients weighing 70 kg)/20 ml/kg (2000 mg/kg that corresponds to 1400 ml for patients weighing 70 kg);
• 15%: 6,7-13,3 ml/kg (1000-2000 mg/kg that corresponds to 470-930 ml for patients weighing 70 kg)/13,3 ml/kg (2000 mg/kg that corresponds to 930 ml for patients weighing 70 kg).

Maximum rate of administering of drug:

• 5%: 2 ml (100 mg) on kg of mass of body/h;
• 10%: 1 ml (100 mg) on kg of mass of body/h;
• 15%: 0,67 ml (100 mg) on kg of mass of body/h.

Children of 2 years
The maximum dose in day:

• 5%: 16-20 ml/kg (800-1000 mg/kg are equivalent);
• 10%: 10-20 ml/kg (1000-2000 mg/kg are equivalent).

At children 18 years are younger than aminoveins of 15% it is not necessary to apply (due to the lack of the necessary clinical data confirming safety and efficiency of drug).

The maximum rate of administering of Aminoven for children corresponds to the maximum speed applied to adult patients.

Side effects

Side reactions at the correct use of Aminoven are unknown.

The disturbances developing at overdose, as a rule, have reversible character and take place independently after the termination of administration of solution.

Any infusions in peripheral veins can lead to development of irritation of walls of vessels and thrombophlebitis.

Special instructions

During therapy it is necessary to exercise control of level of electrolytes, functions of kidneys and balance of liquid.

In case of a hyponatremia/hypopotassemia it is necessary to enter at the same time in enough potassium/sodium.

At administration of any solutions of amino acids development of acute shortage of folates in this connection daily patients need to enter folic acid is possible.

At heart failure administration of liquids in large volumes needs to be carried out carefully.

Because any infusions in a peripheral vein can lead to emergence of irritation of a vascular wall and thrombophlebitis, it is recommended to examine daily the place where the catheter is established. If to the patient the fatty emulsion is also appointed, for the purpose of decrease in probability of development of phlebitis it needs, whenever possible, to be entered along with Aminoven.

The choice of an injection site of drug (installation of a catheter in the peripheral/central vein) is defined by final osmolarity of mix: an osmolarity limit for introduction to a peripheral vein – from 800 to 900 ¼«ß¼«½ý/l. It is also necessary to consider age of the patient, his clinical condition and a condition of his peripheral veins.

Installation of a catheter, in particular in the central vein, it is necessary to carry out with strict observance of aseptic rules.

Solution should be applied right after packaging opening. Before introduction it is necessary to be convinced that it is not damaged, Aminoven transparent and does not contain particles.

Medicinal interaction

Cases of interaction of Aminoven are unknown now.

Because of the increased probability of microbiological pollution and incompatibility to mix Aminoven with other, not applied at parenteral food medicines, does not follow.

Aminoveins, at strict observance of aseptic rules, it is possible to mix with drug Dipeptiven. It is not necessary to add other drugs to mix.

Terms and storage conditions

To store in the place, unavailable to children, at a temperature up to 25 °C, not to freeze.

Period of validity – 2 years.

In sterile conditions Aminoven it is possible to mix with other medicines applied to parenteral food – fatty emulsions, carbohydrates and electrolytes. The prepared mixes need to be used immediately. Storage of mix is possible in exceptional cases – till 24 o'clock at a temperature of 2-8 °C.