Amiodaronum

Amiodaronum – an antiarrhytmic medicine.

Form of release and structure

Amiodaronum produce in the form of tablets with contents 200 mg of Amiodaronum of a hydrochloride and excipients: milk sugar, starch corn, alginic acid, low-molecular povidone, magnesium stearate.

Indications to use

Anti-anginal and antiarrhytmic action of Amiodaronum is caused by property of its active component to influence electrophysiologic processes in a myocardium.

According to the instruction, Amiodaronum is appointed for treatment and prevention of paroxysmal disturbances of a rhythm:

• Supraventricular arrhythmias (at impossibility or small efficiency of other therapy);
• Life-threatening ventricular arrhythmias (including ventricular tachycardia, fibrillation of ventricles);
• Arrhythmias against the background of chronic heart or coronary failure;
• Parasystole, ventricular arrhythmias at patients with Shagas's myocarditis;
• Atrial and ventricular premature ventricular contraction;
• Stenocardia.

Contraindications

Use of Amiodaronum is contraindicated at:

• Sick sinus syndrome;
• Intersticial diseases of lungs;
• AV blockade of the II-III Art. (without use of a pacemaker);
• SA blockade;
• Hypopotassemias;
• Cardiogenic shock;
• Arterial hypotension;
• Collapse;
• Thyrotoxicosis;
• Hypothyroidism;
• Hypersensitivity to medicine components, and also to iodine.

Amiodaronum is contraindicated along with reception of MAO inhibitors, also it is not appointed to pregnant women and the feeding women.

To apply with care to people of advanced age (because of high risk of development of heavy bradycardia), to children and teenagers 18 years (are younger due to the lack of data on efficiency and safety of its use), and also against the background of:

• Liver failure;
• Chronic heart failure;
• Bronchial asthma.

Route of administration and dosage

The scheme and duration of treatment by Amiodaronum is established by individually attending physician.

Pill is taken to food on 200 mg by 2-3 times a day. Gradually daily dosage is reduced to 200-400 mg. In order to avoid cumulation after each 5 days of administration of drug it is necessary to do a break in 2 days. Perhaps daily use of Amiodaronum for 3 weeks with the subsequent break for 7 days.

Against the background of stenocardia the initial dosage makes 0,4-0,6 g a day, divided into 2-3 receptions which in 1-2 weeks is reduced to 200 mg a day.

Side effects

Amiodaronum can cause disturbances from various systems of an organism:

• Sense bodys – adjournment of lipofuscin in a cornea epithelium, a uveitis;
• Nervous system – a sleep disorder and memories, a headache, auditory hallucinations, weakness, a depression, dizziness, feeling of fatigue, paresthesia;
• Cardiovascular system – a sinus bradycardia, AV blockade;
• Respiratory system – an asthma, a bronchospasm, cough, pleurisy;
• Metabolism – a thyrotoxicosis, a hypothyroidism;
• Allergic reactions – exfoliative dermatitis, skin rash;
• The alimentary system – nausea, a loss of appetite, a meteorism, vomiting, obtusion or loss of flavoring feelings, diarrhea, an abdominal pain, heavy feeling in epigastriums, locks.

Other side effects: myopathy, epididymite, decrease in a potentiality, alopecia, vasculitis, photosensitization, bluish or bluish xanthopathies.

Special instructions

Before reception of Amiodaronum it is necessary to conduct X-ray inspection of lungs, and also assessment of function of a thyroid gland and liver. At long therapy X-ray inspection of lungs is recommended to be conducted annually.

During treatment for prevention of emergence of a photosensitization it is recommended to avoid long stay in the sun.

At cancellation of Amiodaronum a recurrence of disturbances of a rhythm is possible.

Analogs

Analogs of Amiodaronum are:

• On active agent – Ritmorest, Kardiodaron, Amiokordin, Vero-Amiodaron, Kordaron;
• On the action mechanism – Multak, Refralon, Nibentan, Ornidum.

Terms and storage conditions

Period of validity of tablets – 2 years. To store in the dry place unavailable to children, at a temperature which is not exceeding 25 °C.