Amiviren – antiviral medicine, nukleozidny inhibitor of the return transcriptase.
Amiviren is issued in the form of tablets, film coated: white, biconvex, round (150 mg) or oval with risky on one of the parties (300 mg), white or white with a yellowish shade on cross section (on 10 pieces in a blister strip packaging from polyvinylchloride and aluminum foil, on 1, 2, 3, 5, 6 or 10 packagings in a cardboard pack; on 60 or 100 pieces in a polymeric can, in a cardboard corrugated box of 1 bank (for hospitals)).
Structure of 1 tablet:
Amiviren apply as a part of complex treatment of HIV infection at children and adults (along with other anti-retrovirus means).
Patients are 16 years old and drug is more senior appoint at a chronic viral hepatitis of B against the background of HBV replication.
Relative (Amiviren apply with care):
Amiviren can appoint only the specialist having experience of treatment of HIV infection.
Pill is taken inside, swallowing completely, without division, to food, in time or after meal. The children and patients experiencing difficulties with a proglatyvaniye of the whole tablet can accept drug in the crumbed view with addition of a small amount of liquid or semisolid food.
The recommended doses:
At a renal failure of moderate severity the initial dose of Amiviren should not exceed 150 mg a day. At a heavy renal failure this dosage form of a lamivudin is contraindicated.
At a liver failure of average and heavy degree dose adjustment is not required.
At patients at late stages of HIV infection or at the long combined anti-retrovirus therapy osteonecrosis cases were noted (frequency of emergence is unknown).
Amiviren do not apply along with a zidovudine at anemia (hemoglobin level less than 4,65 mmol/l) or neutropenias (quantity of neutrophils less 750/mkl).
At emergence of side effects from the alimentary system (nausea, vomiting, abdominal pains) or increase in plasma of level of enzymes of a pancreas drug it is necessary to cancel and not to apply it to an exception of the diagnosis of pancreatitis.
Amiviren does not prevent a possibility of infection with HIV infection through blood or at sexual contact.
During treatment development of consecutive infection is possible.
Experience of use of drug for children is younger than 3 months is absent. At renal failures at children's age the mode of dosing is adjusted in the same proportions, as at adult patients.
At joint reception ламивудин increases duration of therapeutic action of a zidovudine by 13% and for 28% increases its maximum concentration in a blood plasma.
At simultaneous use of Amiviren with a zidovudine and other antiviral drugs which are used at treatment of HIV infections, a synergism is noted.
Streptocides, диданозин and зальцитабин increase risk of development of pancreatitis.
At co-administration with an isoniazid, dapsone, zaltsitabiny, didanoziny or stavudiny the probability of emergence of a peripheral neuropathy increases.
Trimethoprimum increases plasma concentration of a lamivudin.
To store at a temperature no more than 25 °C. To protect from children. A period of validity – 3 years.
The person accepting antidepressants in most cases will have a depression again. If the person coped with depression by own efforts, he has every chance forever to forget about this state.
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