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Таблетки, покрытые оболочкой, АзицидAzitsid – an antibiotic of a broad spectrum of activity from group of azaleads (subgroup of macroleads), active concerning some gram-positive cocci, streptococci, gram-negative bacteria, anaerobic microorganisms; it is not effective at the diseases caused by the gram-positive bacteria steady against erythromycin.

Form of release and structure

Dosage form – tablets, coated: white color, round biconvex – 250 mg; white color, oblong shape – 500 mg (on 3 pieces in the blister, in a pack cardboard 1 or 2 blisters).

Contains in 1 tablet:

  • Active agent: azithromycin (in the form of a dihydrate) – 250 or 500 mg;
  • Kernel: corn starch prezhelatinizirovanny, sodium lauryl sulfate, calcium hydrophosphate, magnesium stearate, croscarmellose sodium;
  • Cover: macrogoal 6000, titanium dioxide, talc, gipromelloza 2910/5, polysorbate 80, emulsion of a simetikon of SE 4 (cellulose metilirovanny, siloksana, silicones, water, sorbic acid).

Indications to use

Azitsid is applied to treatment of the diseases caused by microorganisms, sensitive to azithromycin:

  • Quinsy, pharyngitis, tonsillitis, sinusitis, average otitis (ENT organs and upper airways);
  • Bronchitis, pneumonia – bacterial and atypical (lower parts of respiratory tracts);
  • Impetigo, ugly face for the second time infected a dermatosis (skin and soft tissues);
  • Uncomplicated uretrita and/or tservitsita (urogenital path);
  • Erythema creeping (erythema migrans) – an initial stage of borreliosis (Lyme's disease);
  • Scarlet fever;
  • The diseases of a stomach and 12-perstny gut associated with Helicobacter Pylori (as a part of complex therapy).



  • Renal/liver failure;
  • The children's age up to 3 years or body weight is less than 25 kg;
  • The lactation period (or feeding should be suspended);
  • Hypersensitivity to any component of Azitsid or other macroleads.

Relative (it is required to be careful at administration of drug):

  • Arrhythmia;
  • Pregnancy;
  • The expressed dysfunctions of kidneys/liver at children.

Route of administration and dosage

Azitsid it is necessary to accept in 1 times a day, between meals – in 1 hour prior to food or in 2 hours later.

The recommended dosing modes for adults:

  • Respiratory infections: on 500 mg of 1 times a day within 3 days;
  • Infections of soft tissues and skin: the 1st day – 1000 mg of 1 times a day, 2-5 days – on 500 mg of 1 times a day;
  • Acute infections of urinogenital bodies: 1000 mg once;
  • Erythema migrans: the 1st day – 1000 mg of 1 times a day, 2-5 days – on 500 mg of 1 times a day;
  • The peptic ulcer of a stomach and 12-perstny gut associated with Helicobacter Pylori (as a part of a combination therapy): on 1000 mg/days within 3 days.

The dose for children is defined depending on their weight: on 10 mg/kg of 1 times a day within 3 days or 10 mg/kg in the first day, for the next 3-4 days – on 5-10 mg/kg/days.

At an erythema to children appoint creeping: the 1st day – 20 mg/kg, 2-5 days – on 10 mg/kg.

Side effects

  • Alimentary system: often (more than 3% of cases) – nausea, abdominal pains, diarrhea; seldom (less than 1% of cases) – a melena, a meteorism, dyspepsia, vomiting, increase in activity of hepatic transaminases, cholestatic jaundice; children have a gastritis, anorexia, locks;
  • Cardiovascular system: seldom – thorax pain, a cardiopalmus;
  • Nervous system: seldom – a headache, вертиго, drowsiness; children have an uneasiness, a sleep disorder, neurosis, a hyperkinesia, a headache (at treatment of average otitis);
  • Urinogenital system: seldom – nephrite, vaginal candidiasis;
  • Allergic reactions: rash on skin, a Quincke's edema, a photosensitization; children have an itch, urticaria;
  • Others: candidiasis of a mucous membrane of an oral cavity, increased fatigue; children have a conjunctivitis.

Special instructions

In case of the admission of the next reception it is necessary to accept the passed dose as soon as possible, and the subsequent – with 24-hour intervals.

At co-administration of antacids between administrations of drugs it is necessary to observe a break of ≥2 hours.

At some patients after Azitsid's cancellation hypersensitivity reactions which demand performing specific therapy under medical control can remain.

Medicinal interaction

The food, ethanol and antacids containing magnesium or aluminum slow down and reduce azithromycin absorption.

Linkozamina reduce Azitsid's efficiency, tetracycline and chloramphenicol – increase.

Azithromycin at simultaneous use increases concentration of digoxin, strengthens toxic effect of ergotamine and dihydroergotamine, reduces clearance and strengthens pharmacological action of a triazolam.

Azithromycin slows down removal, than increases concentration in a blood plasma and toxicity of the following medicines: indirect anticoagulants, фелодипин, Cycloserinum, Methylprednisolonum, and also the drugs which are exposed to a microsomal oxidation such as ergot alkaloids, peroral hypoglycemic means, valproic acid, терфенадин, hexobarbital, Bromocriptinum, Disopyramidum, Phenytoinum, cyclosporine, carbamazepine, theophylline and other ksantinovy derivatives.

As macroleads strengthen anticoagulating effect of warfarin, the similar effect can be expected also at simultaneous use of azithromycin therefore at use of this combination it is necessary to control a prothrombin time.

Terms and storage conditions

To store at a temperature up to 25 °C. To protect from children.

Period of validity – 2 years.

Whether you know that:

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