Cerebrolysinum

Cerebrolysinum – nootropic complex drug.

Reviews of Cerebrolysinum confirm high medical performance and safety of drug.

Phenibutum, Gopantam, Nootsetam, Aktovegin, Encephabolum, Gliatilin, Eskotropil, Aminalonum, Tserebril, Gleatser, Tserebrolizat, Aminolasar, Tserakson, Gammalonum, Phenibutum, Ampasse, Semaks, Glitsin, Piracetam, Intellan, Tenoten, Deletsit, Piridol, Minithis, Demanol, Nootsetam, Meksiprim, Korteksin, Nootropil, Idebenon, Neyromit – Cerebrolysinum drugs analogs on pharmacological group. Cerebrolysinum has no structural analogs.

Form of release and structure of Cerebrolysinum

Cerebrolysinum – a hydrolysate of substance of a brain of a pig. Drug contains neuropeptids with a low molecular weight (15%) and about 18 biologically active amino acids (85%).

Cerebrolysinum is issued in the form of solution for injections (an ampoule on 1, 5 and 10 ml). 1 ml of aqueous solution of a medicine contains 0,2152 g of a concentrate of Cerebrolysinum.

Pharmacological action

Active amino acids and peptides of a medicine easily get from blood into neurons, making organospetsifichesky combined effect on a brain. Drug provides neuroprotection, functional neuromodulation, and also metabolism regulation.

According to the instruction Cerebrolysinum and analogs of Cerebrolysinum increase efficiency of power aerobic metabolism in brain tissues, improve proteinaceous synthesis in neurons of the growing old and developing brain, reduce harmful effects of a laktatsidoz, stimulate transsinaptichesky transfer.

Neyprotektivny action of Cerebrolysinum consists in increase in resistance of brain fabric to a hypoglycemia, intoxication, a hypoxia and to other damaging influences. It is established that drug has antioxidant effect (slows down process of free radical oxidation). Besides, Cerebrolysinum makes positive impact on a homeostasis of microelements antioxidants (vanadium, magnesium, selenium, potassium, manganese).

Judging by responses, Cerebrolysinum at regular use promotes activation of processes of cerebration and improvement of mood.

In some responses to Cerebrolysinum it is said that long use of a medicine in treatment promotes improvement of processes of storing and reproduction of information, concentration, ability to receiving and preservation of various skills.

Cerebrolysinum - the only nootropic peptidergichesky medicine with clinically proved neurotrophic activity Neurotrophic activity allows Tserebrolizin to stop or to significantly slow down the progressing neurodegenerative processes in brain tissues.

Indications to use

According to the instruction use of Cerebrolysinum or analogs of Cerebrolysinum is shown at various forms of psychiatric and neurologic, including psychogerontological and neuropediatric pathology which are followed by disturbance intellectual мнестических and cognitive functions.

• syndrome of dementia of various origin (Alzheimer's disease, vascular dementia, senile dementia);
• cerebrovascular insufficiency (chronic form);
• traumatic damages back and brain;
• deficit of attention and hyperactivity at children;
• ischemic stroke;
• endogenous depression steady against antidepressants;
• delay of intellectual development in children;
• senile dementia.

Route of administration

According to the instruction Cerebrolysinum according to indications is applied parenterally (intramusculary or intravenously). The dose and duration of use of Cerebrolysinum depend on age of the patient, and also on weight and the nature of a disease.

At an ischemic stroke, complications of neurosurgical operations, a craniocereberal injury appoint from 10 to 50 ml of drug daily.

At a brain stroke in the acute period, and also at traumatic damage back and a brain it is recommended to enter from 5 to 50 ml of Cerebrolysinum daily.

At a psychoorganic syndrome and a depression appoint from 5 to 30 ml of a medicine daily.

The standard daily dose of drug in neuropediatric practice makes 0,1-0.2 ml/kg of body weight.

At Alzheimer's disease, dementias of the combined and vascular genesis appoint from 5 to 30 ml of Cerebrolysinum.

Therapy duration – 10-20 days. If necessary the course of treatment should be repeated, having reduced frequency of injections to 2-3 weekly.

Contraindications to use of Cerebrolysinum

• hypersensitivity to any component of Cerebrolysinum;
• renal failure (acute form);
• epileptic status;
• allergic diathesis;
• pregnancy.

Side effect

• perspiration, feeling of heat;
• appetite loss;
• dyspepsia;
• locks, diarrhea, vomiting, nausea;
• sleeplessness, excitement, confusion of consciousness;
• tremor, spasms, epileptic seizures;
• headache, painful feelings in extremities, a neck, a lower back;
• asthma, fever, kollaptoidny state;
• burning and itch, dermahemia in the place of an injection;
• arterial hypertension or hypotension;
• depression, fatigue, apathy, dizziness;
• grippopodobny symptoms (cold, cough, infections of a respiratory organs).

Special instructions

According to the instruction Cerebrolysinum in a dose from 10 to 50 ml should be entered only by means of very slow intravenous infusions with preliminary cultivation by special solutions for infusions (Ringer's solution, dextrose solution). Duration of infusions - from 15 minutes to an hour.

After opening of an ampoule/bottle solution of drug needs to be used immediately.

At one-time use Cerebrolysinum, vitamins and medicines improving cordial blood circulation is not recommended to be mixed in one syringe.

Medicinal interaction of Cerebrolysinum

At simultaneous use of Cerebrolysinum with MAO inhibitors or antidepressants mutual strengthening of their action is not excluded.

Storage conditions

It is necessary to store drug at a temperature not vyshe25 °C. Not to freeze!