Tsetrin

International name – Tsetirizin

Pharmacological action and Tsetrin's pharmacokinetics

Tsetrin – is the antagonist of a histamine blocking H1 – histamine receptors. Active ingredient – цетиризин. Tsetrin is shown as prophylactic against allergic reactions, and also for simplification of their course. Renders antipruritic and antiexudative effect. Exerts impact on allergic reactions at an early stage. In a stage of the begun allergic reaction drug limits release of mediators of an inflammation. Tsetrin warns hypostasis of fabrics, removes spasms of smooth muscles, reduces permeability of capillaries. Eliminates skin reactions to offending allergens. Has no antiserotoninovy and anticholinergic effect. At observance of therapeutic doses, has practically no sedative effect. After one-time administration of drug, the beginning of effect, approximately at a half of patients, is observed in 20 minutes, in 1 hour at 95% of patients. The effect of drug lasts more than 24 hours. At therapeutic treatment tolerance to antihistaminic effect of drug does not develop. After the end of treatment the effect of drug remains up to 3 days.

Tsetrin is well absorbed in digestive tract. Administration of drug with food does not exert impact on absorption. The maximum concentration of a tsetirizin in blood comes in 1 hour after administration of drug and 0,3 mkg/ml equal. In insignificant degree the metabolization of drug occurs in a liver. The elimination half-life makes about 10 hours, at elderly patients till 12 o'clock, children have about 6 hours. Drug is emitted, generally with urine.

Indications

Tsetrin's use is recommended at:

• year-round and seasonal rhinitis and conjunctivitis of an allergic origin;
• to small tortoiseshell, including a chronic small tortoiseshell;
• to hay fever;
• allergic dermatitis;
• skin itch;
• Quincke's disease;
• to atopic bronchial asthma (in complex therapy).

Tsetrin's contraindications

• hypersensitivity to a tsetirizin;
• pregnancy;
• lactation.

At Tsetrin's use by persons with a chronic renal failure, and also patients of advanced age and children, it is necessary to show care. About treatment of children is younger than one year Tsetrin of responses it was not received.

Pregnancy and lactation

As well as its analogs Tsetrin is not recommended for use to pregnant women and when breastfeeding.

Side effects

Side effects of Tsetrin can be expressed as drowsiness, dryness in a mouth, dizzinesses, migraines, disorders of digestive tract, allergic reactions are more rare in the form of a headache.

Overdose by Tsetrin

Symptoms of overdose can arise at a single dose of doses of 50 mg. The overdose is shown by dryness in a mouth, drowsiness, an urination delay, locks, concern, an acrimony. It is treated by a gastric lavage, a symptomatic treatment. The antidote does not exist. Efficiency of a hemodialysis is not confirmed.

Tsetrin's dosage and application instruction

Tsetrin is accepted orally, in the form of a tablet is washed down with water, in the form of drops is dissolved in water.

Dosage for children over 6 years and adult – once a day 10 mg of drug, or 2 times a day on 5 mg. To children, since 2 up to 6 years, a half of an adult dose. To children of a year to two, 2 times a day on 2,5 mg (5 drops). To patients with the lowered function of kidneys of 5 mg – once a day. At severe forms of a chronic renal failure, Tsetrin is shown on 5 mg once at 48 o'clock.

Special instructions

According to the received comments Tsetrin, in doses over 10 mg a day, can exert impact on decrease in speed of reaction. In this regard the instruction Tsetrin is recommended to show extra care, during performing therapy, to persons the driving car. Within the recommended doses drug does not strengthen effect of ethanol. However the use of ethanol during therapy is not recommended by Tsetrin's analogs.

Tsetrin's interaction

It was not established a little essential pharmacokinetic interaction of Tsetrin with Cimetidinum, pseudoephedrine, azithromycin, glipizidy, ketokonazoly, diazepam, erythromycin.

Simultaneous use with theophylline leads to reduction of clearance of a tsetirizin, without changing theophylline kinetics.

Storage conditions

Tsetrin is stored in the dry, dark place unavailable to children. It is necessary to store drug at the room temperature which is not exceeding 25 °C.