Dioxidin

Dioxidin – antibacterial drug from group of derivatives of quinoxaline. Has a broad spectrum of activity, having antibacterial, bactericidal effect on various activators – staphylococcus, a pyocyanic stick, pathogenic anaerobe bacterias, and on some on strains of bacteria which are steady against other antibiotics.

Pharmacological action

Active ingredient – hydroxymethylquinoxalinedioxide. The dioxidin is applied at treatment of various pyoinflammatory processes caused by salmonellas, klebsiyelly, stafilokokkam, vulgar Proteus, a dysenteric stick, a pyocyanic stick, streptococci, pathogenic anaerobe bacterias. Promotes bystry clarification and healing of wound surfaces. Also stimulates reparative regeneration. It is widely applied in pediatrics at treatment of rhinitises of various origin.

Release form

The drug Dioxidin is produced in the form of solution and ointment for external use.

• Dioxidin in ampoules of 0,5% and 1% of solution. For topical and intracavitary administration. On 10 ml and 20 ml in an ampoule. On 10 pieces in packaging;
• Ointment for external use of 5%. In tubas on 25 mg, 30 mg, 30 mg, 50 mg, 60 mg, 100 mg.

Indications to use of the Dioxidin

The dioxidin is applied at treatment of the purulent diseases caused by various bacterial infections.

Outwardly apply at:

• Are infected burns;
• Not healing wounds and trophic ulcers, and also for healing of deep and superficial wounds of various localization;
• Phlegmons of soft tissues;
• Purulent wounds at osteomyelites.

Intracavitary introduction of the Dioxidin in ampoules is applied at:

• Purulent processes in a chest and abdominal cavity;
• Lung abscesses;
• Peritonitises;
• At purulent pleurisy and empyemas of a pleura;
• Cystitis;
• Wounds with deep purulent cavities. It can be phlegmons of pelvic cellulose, abscesses of soft tissues, purulent mastitis, postoperative wounds of uric and biliary tract.

Contraindications

The dioxidin according to the instruction is contraindicated at hypersensitivity to active ingredient – hydroxymethylquinoxalinedioxide, and at adrenal insufficiency.

Drug is not used at pregnancy and in the period of a lactation, and also at children's age.

With care according to the instruction the Dioxidin is appointed at a renal failure. If necessary the dose of drug can be reduced.

In pediatrics rather often apply drops in a nose with the Dioxidin at treatment of rhinitises and antritises. Being an antibiotic, drug successfully treats these diseases practically of any origin, having antiinflammatory, antiallergic and antiedematous effect. In a nose apply 0,5% to use of the Dioxidin solution of drug and dig in in each nostril of 4-5 times. Before use it is necessary to consult at the ENT specialist.

Application instruction of the Dioxidin

Most often the Dioxidin is applied in stationary conditions. 1% usually do not use drug solution for intravenous injections (because of instability of drug at storage at low temperatures). Solutions for which receiving drug is dissolved with water for injections or chloride sodium solution apply 0,1-1%.

External use of the Dioxidin:

• For treatment of deep purulent wounds at osteomyelitis – in the form of trays from 0,5-1% solution. Carry out special processing of a wound by administration of drug less often for 15-20 minutes, then apply a bandage with 1% Dioxidin solution. At good tolerance of drug treatment can be carried out daily for 1,5-2 months;
• At treatment of the superficial infected purulent wounds – on a wound impose the napkins moistened in 0,5 - 1% Dioxidin solution. When processing deep wounds they рыхло are tamponed the tampons which are previously moistened in 1% solution. In the presence of a drainage tube – enter 0,5% into a cavity solution, from 20 to 100 ml;
• After operations apply the Dioxidin in the form of 0,1-0,5% of solution to prevention of infections.

For intracavitary introduction use a catheter, the syringe or a drainage tube. Enter 1% into a purulent cavity drug solution, the dose depends on the cavity size, usually – 10-15 ml a day. Usually the drug is administered 1 time a day. The maximum daily dose – 70 ml. It is possible to continue treatment three weeks and more at indications and good tolerance.

Side effects

At intracavitary introduction of Dioksidin can arise:

• Temperature increase;
• Fever;
• Headache;
• Convulsive reductions of muscles;
• Vomiting or nausea;
• Allergic reactions.

At external use dermatitis can develop okoloranevy.

Also at use of the Dioxidin a nevus pigmentosus on skin can sometimes appear. In these cases increase time of introduction of a single dose, reduce a drug dose, appoint antiallergic drugs. In cases if this prevention does not bring result, drug is cancelled.

Treatment with the Dioxidin is begun after conducting test on portability – in the absence of side effects within 3-6 hours after introduction to a cavity of 10 ml of 1% of solution.

The dioxidin is appointed at inefficiency of other antibacterial drugs (karbapenem, cephalosporins II-IV of generations or ftorkhinolon).

Storage conditions

The dioxidin is released according to the recipe of the doctor. A period of storage – 2 years. It is necessary to store at a temperature from 18 ° up to 25 °C. If at storage of drug crystals of active ingredient drop out, ampoules heat on the water bath and stir up before full dissolution. If in process of cooling to 36-38 °C crystals do not drop out, then drug can be used.