Domperidon
Application instruction:
Domperidon – drug with antiemetic action.
Form of release and structure
Domperidon release in the form of tablets, film coated: almost white or white color, biconvex, round; on cross section – an inside layer white with a creamy shade or white color (on 10 pieces in blister strip packagings, on 1-5 packagings in a cardboard pack).
Is a part of 1 tablet:
- Active agent: домперидон – 10 mg;
- Auxiliary components: magnesium stearate – 0,45 mg; microcrystallic cellulose – 60 mg; prezhelatinizirovanny starch – 19,46 mg; colloid silicon dioxide (aerosil) – 0,09 mg; talc – 0,53 mg; titanium dioxide – 0,9 mg; polyvinyl alcohol – 1,44 mg; polyethyleneglycol (macrogoal) – 0,73 mg.
Indications to use
- Vomiting and nausea of various genesis (including at organic and functional diseases, infections, a toxaemia, disturbances of a diet, radiation therapy, when carrying out X-ray contrast and endoscopic researches of digestive tract, and also connected with reception of some medicines – Apomorphinum, morphine, Bromocriptinum and a levodopa);
- Hiccups;
- Need of acceleration of a vermicular movement when carrying out X-ray contrast researches of digestive tract;
- Digestive tract atony (including postoperative);
- Dispepsichesky symptoms at the slowed-down gastric emptying, a gastroesophageal reflux and an esophagitis: heartburn, feeling of overflow in the area epigastriums, feeling of abdominal distention, a gastralgia, a meteorism, an eructation with throwing or without throwing in an oral cavity of gastric contents.
Contraindications
- Mechanical intestinal impassability;
- Bleedings from digestive tract;
- Perforation of intestines or stomach;
- Prolaktinoma;
- Lactation period;
- The age up to 5 years and body weight is less than 20 kg;
- Hypersensitivity to drug components.
Pregnant women can appoint Domperidon only in cases if the estimated advantage for health of mother is higher than potential risk for a fruit.
With care drug should be used at the expressed liver and/or renal failure.
Route of administration and dosage
Domperidon accept inside before food (in 15-20 minutes).
At chronic dispepsichesky symptoms to children of 5 years and adult usually appoint 3-4 times a day 10 mg (in case of need and before going to bed).
At vomiting and the expressed nausea Domperidon accept 20 mg 3-4 times a day (the last reception – before going to bed).
The maximum dose – 80 mg a day.
Patients with a renal failure should adjust a dose and frequency of reception (1-2 times a day are not more often).
Side effects
During therapy development of disturbances from some systems of an organism which are shown with various frequency is possible:
- Nervous system: extrapyramidal frustration (are completely reversible and pass independently after the termination of reception of Domperidon);
- Alimentary system: gastrointestinal frustration (passing enterospasms);
- Allergic reactions: urticaria, skin rash;
- Others: giperprolaktinemiya (gynecomastia, galactorrhoea, amenorrhea).
Special instructions
Domperidon with the antiacid medicines or drugs reducing gastric secretion it is not necessary to accept together at the same time. At Domperidon's reception to food, the listed medicines need to be accepted after food.
Medicinal interaction
At simultaneous use of Domperidon with some medicines there can be undesirable effects:
- Antiacid medicines and M-holinoblokatory: neutralization of action of a domperidon;
- Hydrosodium carbonate, Cimetidinum: decrease in bioavailability of a domperidon;
- Ketokonazol, CYP3A4 isoenzyme inhibitors (antifungal drugs of an azolovy row, antibiotics of group of macroleads, HIV protease inhibitors, нефазодон (antidepressant)): increase in concentration of a domperidon in plasma.
Domperidon is compatible to agonists of dopamine receptors (a levodopa, Bromocriptinum) and antipsychotic medicines (neuroleptics).
Terms and storage conditions
To store in protected from light, the place, dry, unavailable to children, at a temperature up to 25 °C.
Period of validity – 3 years.
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