Дульколакс

Дульколакс – the purgative stimulating an intestines peristaltics.

Form of release and structure

Dosage forms:

• The tablets covered with a kishechnorastvorimy cover: yellow-beige color, a biconvex round form, with a brilliant plain smooth surface, a white kernel (on 10 pieces in blisters, in a cardboard pack 3 blisters);
• Suppositories rectal: a torpedo-shaped form with deepening in the basis, slightly yellow or white color, with an oily or smooth surface (on 6 pieces in strips from aluminum foil, in a cardboard pack 1 strip).

Active ingredient of Dulkolaks – bisacodyl:

• 1 tablet – 5 mg;
• 1 suppository – 10 mg.

Auxiliary components:

• Tablets: starch corn, lactose, глицерол 85%, magnesium stearate, starch corn soluble;
• Suppositories: витепсол W45.

In addition as a part of a kishechnorastvorimy cover of tablets: sucrose, acacias gum, copolymer of methacrylic acid and methylmethacrylate (1:2) (Eudragit of S100), titanium dioxide, copolymer of methacrylic acid and methylmethacrylate (1:1) (Eudragit of L100), castor oil (oil of seeds of a castor-bean tree ordinary), magnesium stearate, macrogoal 6000, wax of karnaubskiya, white beeswax, shellac, dye ferrous oxide yellow (E172), talc.

Indications to use

• Locks at hypotonia of a large intestine (including in a chronic form);
• Purgation by preparation for surgeries, X-ray and tool inspections.

Besides, use of tablets is shown:

• Postoperative therapy;
• Simplification of defecation at various clinical states.

Contraindications

• Intestinal impassability;
• Obstructive pathologies of intestines;
• Appendicitis and other acute diseases of abdominal organs;
• Acute forms of inflammatory diseases of intestines;
• The severe pains in a stomach of an unspecified etiology which are followed by nausea and vomiting;
• The expressed dehydration;
• Hypersensitivity to drug components.

Age contraindications:

• Tablets: up to 4 years;
• Suppositories: up to 10 years.

Only after consultation of the doctor with care it is necessary to apply Dulkolaks during pregnancy (especially in the I trimester) and breastfeeding.

Besides, patients cannot apply tablets with hereditary intolerance of a galactose, fructose, a syndrome of glyukozo-galaktozny malabsorption.

With care it is necessary to appoint tablets at a renal and/or liver failure.

Route of administration and dosage

The tablets covered with a kishechnorastvorimy cover
Tablets apply orally, washing down with a small amount of water.

For approach of laxative effect in the morning days drug is recommended to be accepted the night before (before going to bed).

It is impossible to take a pill together with the milk, antacids, inhibitors of a proton pomp and other products lowering acidity in an upper part of the digestive tract (DT) and promoting premature dissolution of a kishechnorastvorimy cover.

The recommended dosing at locks:

• Patients are more senior than 10 years: an initial dose – 1 tablet, for achievement of an independent regular chair the dose should be raised gradually, but no more than to 2 tablets a day;
• Children aged from 4 up to 10 years: no more than 1 tablet a day.

On the eve of planned operation or by preparation for researches to the patient appoint to night 2 tablets one day before the research and on the eve of operation or a research. Use of tablets in a combination with suppositories is allowed (adult patients in addition to the pill taken in the evening are recommended to enter in the morning 1 suppository).

Suppositories rectal
Suppository is entered into an anus by the pointed end forward.

Defecation comes approximately in 30 minutes.

The usual mode of dosing for adults and children is more senior than 10 years – on 1 suppository a day.

At a preparation for surgery or to researches and the medical states demanding defecation simplification, Dulkolaks's reception has to take place under medical observation.

Side effects

• Alimentary system: spastic pains (at reception of tablets – it is frequent), diarrhea;
• Nervous system: against the background of an intestinal spasm and tension at defecation – dizziness, a faint;
• Immune system: perhaps – hypersensitivity reactions, a Quincke's disease, anaphylactic reactions.

Besides, Dulkolaks's use can cause undesirable effects:

• Tablets: discomfort in a stomach, nausea, vomiting, dehydration, spasms, muscular weakness, a lowering of arterial pressure (ABP), anorectal discomfort, emergence a calla with insignificant amount of blood, colitis;
• Suppositories: pain and local irritation (is more often at patients with an ulcer proctitis or at a proctal crack).

Special instructions

Regular or prolonged use of Dulkolaks is not recommended. At daily need for purgatives, it is necessary to establish the reason of lack of regular independent defecation.

Long use of high doses can lead to excessive loss of liquid, disturbance of electrolytic balance, a hypopotassemia. At emergence of symptoms of dehydration (thirst, an oliguria) against the background of reception of tablets, especially at patients of advanced age or with the accompanying renal failure, therapy should be cancelled.

Emergence in Calais of insignificant amount of blood is usually expressed poorly and takes place independently.

Content of carbohydrates in 1 tablet (5 mg) corresponds to 0,006 grain units (GU).

Dulkolaks's use for children is shown only after consultation of the doctor.

At an enterospasm the patient is recommended to refrain from control of vehicles and mechanisms as because of vazovagalny reaction there can be dizziness and/or a faint.

Medicinal interaction

Use of high doses of Dulkolaks in combination with glucocorticosteroids or diuretics increases risk of development of a hypopotassemia.

Effect of cardiac glycosides strengthens disturbance of electrolytic balance.

Terms and storage conditions

To store in unavailable to children, the dry place at a temperature up to 25 °C.

Period of validity: tablets – 3 years, suppositories – 5 years.