Folacinum

Folacinum is the drug stimulating a hemogenesis and compensating for the deficiency of folic acid of an organism. Is issued in the form of the yellow ploskotsilindrichesky tablets having a facet or to risk on one party.

Pharmacodynamics

Folic acid is group B vitamin. In an organism it will be transformed to tetrahydrofolic acid – the coenzyme necessary for full formation of normoblasts and maturing of megaloblasts, and also participating in different processes of metabolic character. At shortage in an organism of folic acid the megaloblastny type of formation of blood develops. Also folic acid participates in synthesis of amino acids (including glycine, serine and methionine), pyrimidines, purines, nucleic acids, in exchange of a histidine and sincaline, stimulates an erythrogenesis. During pregnancy protects a fruit from damaging and teratogens. Promotes the correct maturing and functioning of a placenta.

Pharmacokinetics

After intake folic acid connects to a specific glycoprotein (an internal factor of Kastl) in a stomach and is completely soaked up in digestive tract. Under the influence of digidrofolatreduktaza enzyme in the presence of ascorbic acid it is deposited and metabolized with formation of tetrahydrofolic acid in a liver. Almost completely contacts plasma proteins.

Folic acid gets into breast milk and through a placenta. The maximum concentration in blood is reached in 30-60 minutes after the use. If the accepted dose exceeds a necessary daily dose, is removed by means of kidneys, both in the form of metabolites, and in not changed look.

Indications for drug Folacinum use

According to the instruction, Folacinum is used for:

• treatment and prevention of shortage of folic acid against the background of defective or unbalanced food;
• treatment and prevention of anemias against the background of shortage of folic acid: leukopenias and anemias which are caused by the ionizing radiation and HP, hyperchromic anemia, post-resection anemia, megaloblastny anemia, anemias connected with a sprue, to a spr and diseases of a small bowel, sideroblastny anemia at elderly people;
• prevention of development in a fruit of defects of a neurotubule.

Folacinum is applied at long treatment by antagonists of folic acid (Trimethoprimum, a sulfamethoxazole combination, a methotrexate), anticonvulsant drugs (phenobarbital, Primidonum, Phenytoinum).

Also apply Folacinum at pregnancy and during the lactic period to treatment and prevention of anemias.

Contraindications to the use

According to the instruction, Folacinum is contraindicated at:

• pernicious anemia;
• hypersensitivity to any of drug components;
• deficit of cobalamine;
• malignant new growths.

Side effects

According to responses, Folacinum can cause allergic reactions: skin rashes, itch, erythema, bronchospasm. Also, according to reviews of Folacinum, from digestive tract nausea, anorexia, bitterness in an oral cavity and abdominal distention can be observed.

Interaction with other drugs

Absorption of folic acid decreases at the simultaneous use with tetracyclines, polymyxins, Neomycinum and chloramphenicol.

At the simultaneous use Folacinum reduces effects of ethanol, a methotrexate, chloramphenicol, Primidonum, Phenytoinum, glyutetimid and Cycloserinum, Sulfasalazinum, contraceptives for internal reception.

Doses and route of administration

Folacinum is used inside.

For prevention of the megaloblastny anemia caused by shortage of folic acid in an organism about 2,5 milligrams of Folacinum a day for four months, for treatment – 5 milligrams a day are used.

For treatment and prevention of macrocytic anemia against the background of defective or unbalanced food, an inflammation of intestines and malabsorption Folacinum is accepted on 15 milligrams a day.

Folacinum at pregnancy is accepted for prevention of development of defects of a neurotubule in a fruit. It should be used on 2,5 milligrams for four weeks before alleged pregnancy and throughout the first trimester of pregnancy.

Special instructions

Patients who are on a hemodialysis should appoint higher doses of folic acid.

At the long use of Folacinum, especially in the raised doses, in blood concentration of cyanocobalamine (B12 vitamin) therefore if it is necessary it is long to accept folic acid can decrease, B12 vitamin use is also appointed.