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Isosorbide

Application instruction:

Pharmacological action

Release form

Indications to use

Contraindications

Application instruction

Side effects

Storage conditions

Изосорбид формула Isosorbide – the nitrocontaining anti-anginal drug used for treatment and prevention of stenocardia.

Pharmacological action

Isosorbide – highly effective drug for treatment of coronary heart disease and stopping of attacks of stenocardia.

Possesses vazodilatiruyushchy, anti-anginal and coronarodilator action, reduces a tone of a wall of vessels and causes a vazodilatation.

Distinguish two types of this nitrocontaining drug, action which it is identical, but has a number of differences:

Isosorbide dinitrate – traditional anti-anginal drug. Reduces pressure and a venous inflow of blood to heart, suffocation, short wind and posineny skin and mucous membranes owing to oxygen insufficiency. At the regular use its anti-anginal and anti-ischemic effect decreases.

Isosorbide mononitrate is quicker soaked up in blood and not metabolized in a liver that provides its big efficiency in comparison with Isosorbide dinitrate.

Release form

Isosorbide mononitrate is produced in a look:

Tablets on 20 mg (on 50 pieces in packaging) and 40 mg (on 20 pieces in packaging);
1% of solution in ampoules on 1 ml (on 50 pieces in packaging).

Isosorbide dinitrate is produced in a look:

Tablets on 5 mg, 10 mg and 20 mg (on 20 and 50 pieces in packaging);
Solution for infusions in ampoules on 10 ml and in bottles on 50 ml.

On the basis of these nitrate connections special drugs in the form of the hypoglossal dosed aerosol and spray, capsules and tablets of the prolonged action and films for gluing on a gingiva are produced.

Indications to Isosorbide use

Isosorbide is applied to stopping and prevention of attacks of stenocardia, recovery treatment after a myocardial infarction, and also at:

Inflammation of an internal cover of arteries;
Some forms of pulmonary hypertensia;
Chronic heart failure;
Pulmonary heart, as a part of a combination therapy.

As means of ambulance to stopping and профилактик an attack of stenocardia, the Isosorbide myocardial infarction dinitrate is applied it is inhalation.

Intravenously drug is used at:

Unstable stenocardia;
Fluid lungs;
Acute myocardial infarction.

Often Isosorbide dinitrate is applied like nitroglycerine to expansion of a gleam of vessels at an acute heart failure.

Isosorbide mononitrate is applied as a part of a combination therapy at treatment of chronic heart failure.

Contraindications

Isosorbide is contraindicated at:

Hypersensitivity to organic nitrates;
The increased intracranial pressure and the lowered arterial pressure;
Brain hemorrhage and craniocereberal injuries;
To closed-angle form of glaucoma (at an open-angle form of glaucoma Isosorbide can be applied).

Isosorbide dinitrate is not applied intravenously at a hemorrhagic stroke, a cardiac tamponade and chronic cardial compression.

With care Isosorbide is appointed at a liver failure, pregnancy and in the period of a lactation. At children's age drug is not used because of insufficiency of clinical trials.

Application instruction of Isosorbide

Изосорбид Pill of Isosorbide of dinitrate is taken inside to food. A standard dose – 5-10 mg of drug 3-4 times a day. The pill taken sublingual (under language, a tablet it is possible to chew for action acceleration), stops stenocardia attacks. At regular reception more than 3-6 weeks recommend to do a break, having replaced drug with this time with other medicines, similar in action.

Isosorbide mononitrate as a part of complex therapy at coronary heart disease and heart failure is applied on 20-40 mg several times a day.

Intravenously enter kapelno or slowly 1-5 ampoules a day.

Side effects

At use of Isosorbide there can be nausea, a headache and dizziness. Often it is symptoms pass with reduction of a dose of drug.

It is impossible to take alcohol at Isosorbide use.

Storage conditions

Isosorbide is carried to list B drugs. A period of storage – 3 years.

Whether you know that:

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