Efferalgan

Efferalgan – the drug relating to group of analgetics antipyretics.

Pharmacological action

Efferalgan represents the non-narcotic analgesic rendering also febrifugal effect. At the heart of its therapeutic action – the mechanism of blocking of TsOG1 and TsOG2 in TsNS with the subsequent impact on the centers of thermal control and pain.

Lack of antiinflammatory effect is explained by neutralization of influence of paracetamol on TsOG. Neutralization is carried out by cellular peroxidases in the inflamed fabrics.

Drug does not exert negative impact on water-salt balance (does not detain water and Na+) and on mucous to a GIT thanks to the fact that Efferalgan does not block synthesis of prostaglandins in peripheral fabrics.

Form of release of Efferalgan

For convenience of use of Efferalgan there are various forms of production of drug:

• The syrup possessing a viscous consistence and caramel and vanilla aroma. Color of syrup – yellowy-brown. Syrup Efferalgan is packed into bottles of 90 ml. The bottle and the measured spoon which is included in the package are placed in a cardboard pack;
• The suppositories of white color intended for rectal use. They are distinguished by a smooth glossy surface. Suppositories are packaged in blister strip packagings in number of 5 pieces. One cardboard pack contains 2 packagings;
• Tablets flat and round. At tablets slanted edges and a notch on one of the parties, their color – white. Dissolution of tablets in water is followed by active allocation of vials of gas. Tablets in number of 4 pieces are packed into strips, in one box there are 4 or 25 strips;
• The sparkling tablets containing vitamin C. A form of release and the same outward, as at usual tablets Efferalgan. Tablets are packed into tubas on 10 pieces. One cardboard box contains one tuba.

There are also special forms of medicine intended for children:

• The sparkling powder intended for preparation of solution for oral administration;
• Solution for intake;
• Rectal suppositories.

Indications to Efferalgan's use

According to the instruction to Efferalgan drug is recommended for use in the following cases:

• As an antipyretic at flu, respiratory diseases in an acute form, at post-inoculative reactions, at children's infections and at other diseases which are characterized by emergence of an inflammation and fervescence against the background of an infection;
• As the drug having analgesic effect at pain syndromes of moderate or weak intensity (including the tooth, head pains, muscular pains, pains caused by injuries and burns, neuralgia).

Contraindications

Medical reviews of Efferalgana note existence of a number of contraindications which list it is necessary to study before drug use:

• Abnormal liver functions and/or kidneys in severe forms;
• Condition of deficit glyukozo-6-fosfatdegidrogenazy;
• Various diseases of blood;
• Age less than one month;
• Hypersensitivity to any of Efferalgan's components, especially to parabens (propyl - and to methylparahydroxybenzoate).

Efferalgan with care at disturbances of functioning of a liver and/or kidneys in weak or moderate degrees is recommended to apply, and also at Gilbert's syndrome.

Application instruction of Efferalgan

The instruction to Efferalgan orders to accept drug inside (unless otherwise specified), washing down with a large amount of water. Between meal and use of medicine there have to pass not less than 1 hour, but no more than 2 hours.

The dosage varies depending on age of the patient:

• For adults and teenagers 12 years (if their weight exceeds 40 kg) a single dose are more senior 500 mg, the maximum one-time – 1 g equal. Use frequency – no more than 4 times a day. The maximum dose in days – 4 g. Duration of treatment should not be more than 5 days – one week;
• To children up to 6 months and less than 7 kg the dose equal to no more than 350 mg of Efferalgan in days is appointed; to children about one year (whose weight is less than 10 kg) – 500 mg; to children up to 3 years and weighing less than 15 kg – 750 mg; to children 6 years and weighing less than 22 kg – 1 g of medicine are younger; up to 9 years and less than 30 kg – 1,5 g; up to 12 years and less than 40 kg – 2 g of Efferalgan as much as possible. If the age of the child less than 3 months, but more than 1 month, a dosage is appointed by the doctor.

The interval between drug intakes has to make not less than 4 hours. Duration of reception of Efferalgan without medical consultation cannot be more than 3 days (for decrease in heat) and no more than 5 days if drug is used as an analgetic.

Rektalno Efferalgan it is also necessary to enter, being guided by age of the patient: the dosage for adults makes 500 mg from 1 to 4 times a day, maximum one-time – 1 g, daily – 4 g. Efferalgan is recommended to children from 12 to 15 years in number of 250-300 mg from 3 to 4 times in one days; to children, whose age from 8 to 12 years, it is necessary to accept drug in the same dosage three times a day; of 6-8 years the same necessary dosage, frequency decreases to 2-3 times; from 4 to 6 years – 150 mg on 3-4 times a day; for children from 2 to 4 years the same dose, frequency – to 3 times; of a year to two – on 80 mg 3 or 4 times a day; of half a year about one year – the same dosage with a frequency of 2-3 times; of 3 months before half a year to accept 80 mg no more than 2 times every day.

Side effects of Efferalgan

Efferalgan's use is capable to cause emergence of undesirable reactions. They are described below:

• Allergic reactions in the form of a Quincke's edema, an itch, skin rash;
• Vomiting, nausea, gripes and pains in a stomach, hepatotoxic actions;
• Leukopenia, anemia, agranulocytosis, pancytopenia, methemoglobinemia, thrombocytopenia;
• The nephrotoxic action arising at the long use of Efferalgan in high doses.

Special instructions

Medical reviews of Efferalgana note probability of increase in the most admissible daily dose at a concomitant use of drug with other means as a part of which there is a paracetamol.

Lack of therapeutic effect (preservation of symptoms of fever for the term of more than 3 days and a pain syndrome for the term of more than 5 days) – an occasion to see behind consultation a doctor.

To patients with a diabetes mellitus, and also to the patients keeping to the diet assuming a sugar exception it must be kept in mind that 1 ml of drug contains sugar in number of 0,335 g.

Storage conditions

Efferalgan has to be stored at a temperature which is not exceeding a mark of 30 °C, far away from children. The period of validity makes 3 years.