Ethinylestradiol

Ethinylestradiol – the hormonal means applied at treatment of the diseases caused by shortage of estrogen.

Pharmacological action

Active component of Ethinylestradiol causes proliferation of an endometria and promotes more snowballing of uterine tubes, a uterus, and also secondary female sexual characters in cases of their underdevelopment. It allows to soften or eliminate completely in a female body of an effect which arise owing to insufficient function of gonads.

Besides, active agent of Ethinylestradiol:

• Has slight anabolic effect;
• Causes a delay of sodium and water (at use in high doses);
• Has gipokholesterinemichesky effect (promotes decrease in level of cholesterol in blood);
• Increases absorption of calcium and promotes formation of calcic depots in bones.

Release form

Medicine Ethinylestradiol is produced in the form of tablets on 10 and 50 mkg.

On the mechanism of action treat Ethinylestradiol analogs: Divigel, Klimara, Ovestin, Hexestrol, Elvagin, Estrozhel, Estrovagin, Ovipol Clio, Estrokad.

As active component Ethinylestradiol is a part of such combined drugs as Marvelon, Mersilon, Lindinet 20, Hloye, Rigevidonum, Bellune 35, Mikrofollin, Novinet, Yarina, Tri-regol, Rigevidonum, Lindinet 30, Triziston, Zhenetten, Trikvilar, Logest, Rangning, Jes, Femoden, Midiana.

Indications to Ethinylestradiol use

According to the instruction Ethinylestradiol is appointed at treatment:

• Hypo-ovarias (dysmenorrhea, primary and secondary amenorrhea, oligomenorrhea, hypomenorrhea);
• Androgen-dependent prostate cancer;
• Infertility;
• Metrorrhagias (including therapy in a climacteric);
• Hypogonadism;
• Vaginitis (both at girls, and in the period of a postmenopause);
• Some forms of a breast cancer;
• Secondary oestrogenic insufficiency;
• Sexual infantility;
• Acne;
• Postkastratsionny and climacteric frustration.

Besides, Ethinylestradiol is applied to suppression of a lactation after the delivery, and as a part of the combined drugs – to contraception.

Ethinylestradiol contraindications

It is contraindicated to apply ethinylestradiol at:

• Breast cancer and others it is oestrogenic - dependent new growths;
• Herpes of pregnant women in the anamnesis;
• Vaginal bleeding of not clear genesis;
• Pregnancies and lactations;
• Endometriosis;
• Serious cardiovascular illness;
• Thromboses and thrombembolia;
• Sickemia;
• Liver failure.

It is necessary to be careful at reception of Ethinylestradiol against the background of:

• Epilepsies;
• Bronchial asthma;
• Heart diseases and kidneys;
• Migraines;
• Hypercalcemias;
• Otosclerosis;
• Arterial hypertension;
• System lupus erythematosus;
• Multiple sclerosis.

Ethinylestradiol route of administration

The dosage of Ethinylestradiol and duration of its use depend on indications.

At an oligomenorrhea and an amenorrhea, as a rule, Ethinylestradiol appoint in a daily dosage 0,02-0,1 mg for twenty days.

At a dysmenorrhea reception from one to three tablets (10 mkg) a day for twenty days is shown (since 4-5 in the afternoon a menstrual cycle). Treatment is effective within 2-3 months.

At climacteric frustration of the woman 45 years are younger accept 0,05 mg a day.

Treatment by cancer Ethinylestradiol (as mammary gland at women of 60 years, and a prostate) usually long. The single dose varies from 0,05 to 0,1 mg three times a day. As a rule, treatment is combined with radiation therapy.

At treatment of an acne appoint from 3 to 6 tablets (on 10 mkg) in day, during puberty – from one to three tablets.

At use of Ethinylestradiol for oppression of a lactation accept 0,02 mg three times a day for the first three days after the delivery then the dosage is gradually reduced. The general duration of reception of Ethinylestradiol usually makes 9 days.

Medicinal interaction

At the carried-out therapy by Ethinylestradiol it is necessary to consider that the estrogen which is a part of drug reduces effects of anticoagulants, and also hypoglycemic and anti-hypertensive means.

Side effects of Ethinylestradiol

According to reviews Ethinylestradiol can cause frustration of various systems of an organism, namely:

• Skin hyperpegmentation (dermatological reactions);
• Change a libido, morbidity and increase in mammary glands, decrease in tolerance to glucose (endocrine system);
• Dysfunctions of digestive tract, nausea, vomiting, abnormal liver functions, jaundice (alimentary system);
• The increased tendency to a thrombogenesis (circulatory system);
• Headache, depression, dizziness, migraine (nervous system);
• Increase in body weight and hypostases (metabolism).

Storage conditions

Ethinylestradiol belongs to a number of hormonal medicines of the list B with the recommended period of storage 24 months.