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Caffeine

Application instruction:

Form of release and structure

Indications to use

Contraindications

Route of administration and dosage

Side effects

Special instructions

Medicinal interaction

Terms and storage conditions

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In more detail

Caffeine – psychogogic drug.

Form of release and structure

Caffeine is produced in the form of solution for hypodermic introduction: transparent, colourless or slabookrashenny (in ampoules on 2 ml, on 5 ampoules in blister strip packagings, on 2 packagings in a cardboard pack; on 5 or 10 ampoules in a cardboard pack with partitions or lattices).

Is a part of 1 ml of solution:

Active agent – mg caffeine-sodium benzoate 100 or 200;
Auxiliary components: solution of natron caustic 0,1M – to рН 6,8-8‚5, water for injections – to 1 ml.

Indications to use

Decrease in physical and intellectual effeciency;
Moderate arterial hypotonia;
Muscular weakness;
Migraine;
Drowsiness;
Respiratory depression (including at slight poisonings with opioid analgetics and somnolent medicines, carbon monoxide, at asphyxia of newborns, for recovery of necessary level of lung ventilation after use of the general anesthesia).

Contraindications

Organic diseases of cardiovascular system (including an acute myocardial infarction, atherosclerosis);
Arterial hypertension;
Sleep disorders;
Glaucoma;
Bouveret's disease;
Hyperexcitability;
Epilepsy and tendency to convulsive attacks;
Frequent ventricular premature ventricular contraction;
Advanced age;
Pregnancy and period of a lactation;
Hypersensitivity to drug components.

Route of administration and dosage

Caffeine is entered subcutaneously.

The adult usually appoint 1 ml 100 mg/ml or 200 mg/ml of solution. The maximum dose makes: one-time – 400 mg, daily – 1000 mg.

To children depending on age, as a rule, appoint 0,25-1 ml 100 mg/ml of solution.

Frequency rate and duration of use are defined by the doctor.

Side effects

During use of Caffeine the following side effects can develop:

Central nervous system: tachypnea, sleep disorder, tremor, excitement, alarm, headache, spasms, dizziness;
Cardiovascular system: disturbance of a heart rhythm, tachycardia, increase in arterial pressure;
Alimentary system: nausea, diarrhea, vomiting, aggravation of a peptic ulcer.

At long use perhaps insignificant accustoming (decrease in action is connected with education in cells of a brain of new adenosine receptors).

Special instructions

During use of Caffeine it is necessary to consider that the sudden termination of therapy can lead to strengthening of braking of the central nervous system in the form of drowsiness and a depression.

Impact on the central nervous system can be shown both by excitement, and braking of the highest nervous system.

Medicinal interaction

At simultaneous use of Caffeine with some medicines there can be following effects:

Narcotic and hypnagogues: decrease in their efficiency;
Non-narcotic analgesics and ergotamine: increase in their efficiency (due to increase in absorbability);
Cardiac glycosides: strengthening of their action and increase in toxicity.