Liprazid

Liprazid – the combined anti-hypertensive drug.

Form of release and structure

Dosage form – tablets (on 10 pieces in a blister strip packaging, in a pack cardboard 1 or 3 packagings).

The active ingredients which are contained in 1 tablet:

• Lisinopril a dihydrate (in terms of lisinopril) – 10 or 20 mg;
• Hydrochlorthiazidum – 12,5 mg.

Indications to use

Liprazid is applied to treatment of various forms of arterial hypertension (as monodrug or as a part of a combination therapy).

Contraindications

Absolute:

• Age up to 18 years;
• Pregnancy;
• Lactation;
• Simultaneous use of drugs of lithium;
• The idiopathic or hereditary Quincke's edema or Quincke's edema caused by use of inhibitors of an angiotensin-converting enzyme (in the anamnesis);
• Heavy renal failures (clearance of creatinine less than 30 ml/min.), an anury, a bilateral stenosis of renal arteries or a stenosis of an artery of the only kidney, and also the period of passing of a hemodialysis using high-strength membranes (polyacrylonitrile, metilosulfonatny);
• Hypersensitivity to Liprazid's components or derivatives of sulfonamide.

Relative (it is necessary to observe extra care in connection with risk of development of complications):

• Mitral and/or aortal stenosis;
• Coronary heart disease;
• Cerebrovascular frustration;
• Dysfunction of kidneys/liver;
• Alcoholism;
• The states which are followed by increase in level of potassium in blood;
• The period before operation using the general anesthesia;
• Subaortic hypertrophic stenosis;
• Heavy heart failure;
• Diabetes mellitus;
• Disturbances of water and electrolytic balance;
• Stenosis of renal arteries;
• Hypovolemia;
• Collagenoses;
• Advanced age;
• Diet with the lowered content of sodium.

It is necessary to be careful at purpose of drug to the patients who are on a hemodialysis.

Route of administration and dosage

Liprazid accept inside, swallowing tablets entirely, washing down with enough liquid, regardless of meals, but it is desirable at the same time days. If necessary the tablet can be divided into parts.

Doses and duration of treatment by drug are defined by the doctor individually for each patient. Usually appoint 5-10 mg 1 times/days. If 1-2 weeks of reception of Liprazid later the therapeutic effect is expressed insufficiently, the dose is gradually raised. The recommended maintenance dose makes 20 mg of 1 times a day.

The most admissible daily dose for patients with normal function of kidneys – 80 mg.

The initial dose for patients with a renal failure (clearance of creatinine more than 30 ml/minute) and patients with renovascular arterial hypertension makes 2,5 mg of 1 times a day.

Before Liprazid's appointment the doctor has to provide to the patient the complete information about symptoms of a Quincke's disease.

Side effects

• Digestive tract and liver: a xerostomia, pains in epigastric area, digestion disturbances, a loss of appetite, nausea, vomiting, disturbance of a chair; in isolated cases – changes of flavoring feelings, jaundice, pancreatitis, hepatitis;
• Central and peripheral nervous system: increased fatigue, headache, disturbance of the mode of dream/wakefulness, dizziness, emotional lability, acrimony, weakness, paresthesias, spasms; in isolated cases – an asthenic syndrome, confusion of consciousness;
• Cardiovascular system and system of a hemopoiesis: disturbance of a cordial rhythm, thrombocytopenia, feeling of pain and pressure in a breast, an excessive lowering of arterial pressure, including orthostatic hypotension, a neutropenia, anemia, an agranulocytosis, a leukopenia;
• Urinary system: anury, uraemia, renal failure, acute renal failure;
• Laboratory indicators: an eosinophilia, increase in a blood sedimentation rate, a leukocytosis, change of level of potassium in blood, reduction of tolerance to glucose, increase in activity of liver enzymes, decrease in level of chlorine, magnesium and sodium in blood, increase in level of creatinine, calcium, bilirubin, glycerides, urea, cholesterol;
• Allergic reactions: alopecia, small tortoiseshell, photosensitivity, itch, skin rash, bronchospasm, Quincke's edema;
• Others: disturbance of a respiratory rhythm, cough, the increased perspiration, muscle and joints pains, decrease in a potentiality; at prolonged treatment – gout.

Special instructions

Before an initiation of treatment women of childbearing age are recommended to exclude pregnancy.

In need of Liprazid's use during a lactation it is necessary to consult with the doctor and to resolve an issue of breastfeeding interruption.

During therapy by drug it is necessary to be careful at control of vehicles and performance of potentially dangerous types of works.

Medicinal interaction

Possible reactions of interaction in case of Liprazid's use along with other medicines:

• Gipoglikemiziruyushchy drugs: decrease in their therapeutic effects;
• Cyclosporine, chloride sodium solution, kaliysberegayushchy diuretics and drugs of potassium, non-steroidal anti-inflammatory drugs, estrogen: decrease in efficiency of Liprazid (potassium drugs, kaliysberegayushchy diuretics, indometacin and cyclosporine also increase risk of development of a hyperpotassemia);
• Thiazide and loopback diuretics: strengthening of hypotensive effect of drug;
• Tetracyclines, antacids, enterosorbents, холестипол, холестирамин: decrease in absorption of active agents of Liprazid;
• Digoxin: increase in its toxicity;
• Lithium drugs, амантадин: delay of their removal;
• Tubocurarine: strengthening of its action;
• Methyldopum: risk of development of an intravascular hemolysis;
• Barbiturates, alcohol, narcotic medicines: risk of development of a hypopotassemia and orthostatic hypotension;
• Cardiac glycosides: risk of development of a hypopotassemia;
• Amiodaronum: probability of development of arrhythmia;
• Allopyrinolum, procaineamide, system glucocorticosteroids, cytostatics, immunosuppressive drugs: risk of development of a leukopenia;
• Not depolarizing muscle relaxants: strengthening of their effects.

Terms and storage conditions

To store at a temperature 15-25ºС in the dry place, to protect from influence of direct sunshine.

Period of validity – 3 years.