Nolicin

Nolicin – antibacterial medicine of group of ftorkhinolon.

Form of release and structure

Dosage form of production of Nolicin – a tablet, film coated: orange, round, a little biconvex, on one party – with risky (on 10 pieces in blisters, on 1 or 2 blisters in a cardboard pack).

Is a part of 1 tablet:

• Active agent: norfloxacin – 400 mg;
• Additional components: povidone, sodium carboxymethylstarch, microcrystallic cellulose, colloid anhydrous silicon dioxide, magnesium stearate, the purified water;
• Cover: gipromelloza, talc, titanium dioxide, propylene glycol, yellow dye sunset (E110) (yellow disperse dye, E110).

Indications to use

Nolicin is appointed for treatment of the infectious and inflammatory diseases caused by the activators showing sensitivity to effect of norfloxacin:

• Bacterial gastroenteritis, including a shigellosis, a salmonellosis;
• Gonorrhea is uncomplicated;
• Infections of generative organs, including an endometritis, a cervicitis, chronic bacterial prostatitis;
• Infectious diseases of urinary tract in an acute and chronic current, including cystitis, an urethritis, pyelonephritis;
• Infections of urinary tract (for prevention of a recurrence);
• Sepsis (for prevention at patients with a neutropenia);
• Diarrhea of travelers (for prevention).

Contraindications

Absolute:

• Deficit glyukozo-6-fosfatdegidrogenazy;
• Pregnancy and the period of a lactation (to pregnant women purpose of Nolicin is possible only according to vital indications if the expected advantage for health of the woman is higher than possible risk for a fruit);
• Age up to 18 years;
• Hypersensitivity to drug components, and also other medicines of group of ftorkhinolon.

Relative (Nolicin is appointed with care against the background of the following diseases / states):

• Atherosclerosis of vessels of a brain;
• Epilepsy and epileptic syndrome;
• Disturbances of cerebral circulation;
• Existence of allergic reaction to acetylsalicylic acid;
• Liver/renal failure.

Route of administration and dosage

Nolicin is accepted inside, washing down with liquid in enough, it is more preferable – on an empty stomach (observing intervals: it is not less than 1 hour to or in 2 hours after food).

The recommended course duration at Nolicin reception 2 times a day on 400 mg:

• Chronic bacterial prostatitis: 4-6 weeks or longer;
• Uncomplicated gonorrhea: 3-7 days; the single dose of drug in a dose of 800-1200 mg is also possible;
• Bacterial gastroenteritis (shigellosis, salmonellosis): 5 days;
• Acute uncomplicated cystitis: 3-5 days;
• Sepsis at a neutropenia (prevention): 2 months.

The recommended daily dose for prevention of diarrhea of travelers – 400 mg. Drug is accepted in 1 day prior to departure, during all travel and for 2 days after its termination. The general course should not exceed 3 weeks.

With the preventive purpose at recurrent uncomplicated infections of urinary tract (aggravation frequency – is more than 2 episodes within half a year or more than 3 in a year) Nolicin is appointed it is long (of half a year up to several years) on 200 mg once a day. Drug is accepted for the night.

At clearance of creatinine it is less than 20 ml in a minute (or the level of serumal creatinine more than 5 mg/dl) and the patient who is on a hemodialysis the daily dose is reduced, reducing a single dose twice without change of frequency rate of administration of drug or reducing frequency rate of administration of drug to 1 time a day at preservation of a full therapeutic dose.

Side effects

• Allergic reactions: skin itch, rash, hypostases, urticaria, malignant exudative erythema (Stephens-Johnson's syndrome);
• Nervous system: hallucinations, headache, unconscious states, dizziness, sleeplessness; elderly patients have an irritability, sensation of fear, fatigue, concern, drowsiness, a sonitus, a depression;
• Alimentary system: vomiting, a loss of appetite, nausea, bitterness in a mouth, an abdominal pain, diarrhea, a pseudomembranous coloenteritis (at long therapy), increase in activity of hepatic transaminases;
• Skeletal and muscular system: tendinites, an arthralgia, ruptures of sinews (as a rule, against the background of the factors promoting it);
• Urinary system: glomerulonephritis, albuminuria, crystalluria, polyuria, dysuria, urethral bleedings, increase in creatinine and urea of a blood plasma;
• Hemopoietic system: decrease in a hematocrit, leukopenia, eosinophilia;
• Cardiovascular system: vasculitis, arrhythmias, tachycardia, lowering of arterial pressure;
• Others: candidiasis.

Special instructions

During therapy by Nolicin patients have to receive liquid in enough (under control of a diuresis).

In case of pains in sinews or the first symptoms of a tendovaginitis drug needs to be cancelled. It is recommended to avoid excessive exercise stresses during treatment.

With allergic reaction to acetylsalicylic acid E110 azoic dye can cause hypersensitivity reactions in patients, up to a bronchospasm.

During therapy the prothrombin ratio (when carrying out surgical interventions it is necessary to exercise control of a condition of system of a blood coagulation) can increase.

Throughout a course of treatment it is recommended to avoid impact of a direct sunlight.

During reception of Nolicin when driving and performing other potentially dangerous works demanding bystry psychomotor reactions and high concentration of attention it is necessary to be careful.

Also care is demanded by the ethanol use, simultaneous with drug.

Medicinal interaction

At the combined use of Nolicin with some drugs the following effects can be observed:

• Theophylline: decrease in its clearance and, as a result, increase in probability of development of undesirable side effects (control of concentration of theophylline in a blood plasma and, if necessary, correction of its dose is necessary);
• Nitrofurans: decrease in their efficiency;
• Cyclosporine, warfarin: strengthening of their therapeutic action, increase in concentration of serumal creatinine (control of this indicator is necessary);
• Antiacid means with the content of aluminum hydroxide or magnesium, and also drugs with the content of iron, zinc, a sukralfat: decrease in absorption of norfloxacin (it is necessary to observe a break between receptions of these drugs not less than 2 hours);
• The drugs promoting decrease in a convulsive threshold: development of epileptiform attacks;
• Glucocorticosteroids: increase in cases of a rupture of sinews or risk of tendinites;
• Hypoglycemic drugs (sulphonylurea derivatives): strengthening of their therapeutic action;
• The medicines potentially capable to lower arterial pressure: its sharp decrease (control of heart rate, indicators of an ECG and arterial pressure even in cases of simultaneous introduction with barbiturates and other drugs is necessary for the general anesthesia).

Terms and storage conditions

To store in protected from light, the place, dry, unavailable to children, at a temperature up to 25 °C.

Period of validity – 5 years.