Pantogamum

Pantogamum – the drug having nootropic and anticonvulsant effect.

Form of release and structure

• Tablets: a ploskotsilindrichesky form, white color, with risky and a facet (on 10 pieces in blister strip packagings, on 5 packagings in a pack cardboard);
• Syrup: colourless or slightly yellowish color, possesses a cherry smell (on 100 ml in dark glass bottles, in a pack the cardboard 1 bottle, is included in the package a measured spoon of 5 ml).

Active agent – calcic salt of gopantenovy acid, its contents:

• 1 tablet – 0,25 or 0,5 g;
• 5 ml of syrup – 0,5 g.

Excipients of tablets: methyl cellulose, magnesium hydroxycarbonate, calcium stearate, talc.

Syrup excipients: sorbitol, Natrium benzoicum, глицерол, aspartame, monohydrate of citric acid, the purified water, fragrance food "Cherry 667".

Indications to use

• Psychoemotional overloads, decrease in physical/intellectual effeciency (the drug use purpose – improvement of storing and concentration of attention);
• Akinetic and hyperkinetic extrapyramidal syndrome owing to reception of neuroleptics (treatment and prevention);
• Extrapyramidal disturbances (including chorea of Gentington, Parkinson's disease, hepatolenticular degeneration, myoclonus epilepsy);
• Cognitive disturbances owing to neurotic disorders and organic lesions of a brain (including effects of craniocereberal injuries and neuroinfections);
• Neurosis-like states at tics, stutter (preferential clonic form), an inorganic enkoprez and enuresis;
• Cerebrovascular insufficiency owing to atherosclerotic changes of vessels of a brain;
• Hyperkinetic frustration, including hyperactivity syndrome with deficit of attention;
• Epilepsy with delay of mental processes (in a combination with anticonvulsants);
• The schizophrenia which is followed by organic cerebral insufficiency;
• Neurogenic frustration of an urination (pollakiuria, enuresis, imperative desires, imperative incontience of urine);
• The disturbances of the psychological status at children which are shown the general delay of mental development, specific disorders of motive functions, speeches and their combination, formations of school skills (the letter, reading, the account, etc.);
• Mental retardation, including with behavioural disturbances;
• Various forms of cerebral palsy;
• Perinatal encephalopathy at children from the first days of life.

Contraindications

Absolute:

• Fenilketonuriya (for syrup; because of the content of aspartame);
• Acute serious illness of kidneys;
• Pregnancy and feeding by a breast;
• Hypersensitivity to any component which is a part of drug.

Route of administration and dosage

Both dosage forms of Pantogamum should be taken inside in 15-30 minutes after meal, considering its nootropic action – in morning and day time (till 17 o'clock).

In the form of tablets drug is appointed to adults and children 3 years are more senior, it is reasonable to children of early age to apply syrup.

Average doses for adults make: one-time – 0,25-1 g, daily – 1,5-3 g; for children: one-time – 0,25-0,5 g, daily – 0,75-3 g.

Treatment duration – from 1 to 4 months, in some cases – 6 months. If necessary in 3-6 months of a break appoint a repeated course of therapy.

The recommended dosing modes:

• Schizophrenia (as a part of complex therapy with psychotropic drugs): on 0,5-3 g a day within 1-3 months;
• Epilepsy (in a combination with anticonvulsant drugs): on 0,75-1 g a day, treatment can last till 1 year and more;
• Extrapyramidal antipsychotic syndrome (along with the main therapy): to 3 g a day within several months;
• Extrapyramidal hyperkinesias at patients with hereditary diseases of a nervous system (along with the main therapy): on 0,5-3 g a day, treatment duration – up to 4 months and more;
• Effects of craniocereberal injuries and neuroinfections: on 0,25 g 3-4 times a day;
• Asthenic states and the raised loadings (for maintenance): on 0,25-0,5 g 3 times a day;
• Extrapyramidal syndrome owing to use of neuroleptics: adults – on 0,5-1 g 3 times a day, children – on 0,25-0,5 g 3-4 times a day, carry out treatment within 1-3 months;
• Tics at children: on 0,25-0,5 g of 3-6 times a day a course from 1 to 4 months;
• Disturbances of an urination: adults – on 0,5-1 g 2-3 times a day, children – on 0,25-0,5 g a day (0,025 - 0,05 mg/kg) within 1-3 months;
• Pathologies of a nervous system at children: till 1 year – on 0,5-1 g a day, 1-3 years – on 0,5-1,25 g a day, 3-7 years – on 0,75-1,5 g a day, are more senior than 7 years – 1-2 g a day. Treatment is always begun with the minimum dose and gradually, within 7-12 days, it is raised. In the maximum dose drug is used for 15-40 days then gradually, within 7-8 days, gradually reduce a dose up to full drug withdrawal. The general course of treatment lasts from 30 to 90 days, in some cases can reach 6 months and more.

Side effects

• Allergic reactions: conjunctivitis, rhinitis, skin rashes (these reactions demand a dose decline of drug or full cancellation);
• Others: drowsiness or sleep disorders, noise in the head (these phenomena usually have short-term character and do not demand the therapy termination).

Special instructions

At prolonged use of Pantogamum it is not recommended to appoint at the same time other nootropic drugs and means stimulating the central nervous system.

Due to the probability of emergence of drowsiness in the first days of therapy it is necessary to be careful when driving and performing potentially dangerous types of works.

The break between therapy courses Pantogamum, as well as any other nootropic drug, has to make 1-3 months.

Medicinal interaction

It must be kept in mind that Pantogamum:

• Prevents by-effects of carbamazepine, phenobarbital, neuroleptics;
• Prolongs action of barbiturates;
• Exponentiates effect of local anesthetics (Procainum);
• Strengthens effects of anticonvulsants.

Etidronovy acid and glycine strengthen effect of calcic salt of gopantenovy acid.

Terms and storage conditions

To store in dry (tablets), protected from light and the place, unavailable to children, at a temperature up to 25 ºС.

Period of validity:

• Tablets of 0,25 g – 4 years;
• Tablets of 0,5 g – 3 years;
• Syrup – 2 years, after the first opening of a bottle – no more than 1 month on condition of storage in the refrigerator.