Poludanum

Poludanum – immunoexcitant with the expressed antiviral and immunomodulatory action.

Form of release and structure

Dosage forms:

• Lyophilisate for preparation of solution for injections: the mass of white color (on 100 action units (AU) in ampoules on 1 ml or in bottles on 5 ml, in a cardboard pack of 10 ampoules or bottles);
• Lyophilisate for preparation of eye drops (in bottles with a capacity of 5 ml on 100 PIECES, in a cardboard box 1 or 3 bottles complete with 1 or 3 sterile covers droppers);
• Lyophilisate for preparation of nasal drops (in bottles with a capacity of 5 ml on 100 PIECES, in a cardboard box 1 or 3 bottles complete with 1 or 3 sterile covers droppers);
• Drops are nasal: colourless transparent liquid (on 5 ml in glass bottles, in a cardboard pack of 1, 3 or 100 bottles complete with 1, 3 or 100 covers droppers).

Content of active agents of Poludanum in 100 PIECES of lyophilisate / 1 ml of drops nasal:

• Potassium полирибоаденилат (potassium salt of poliriboadenilovy acid) – 0,1 mg / 0,05 mg;
• Potassium полирибоуридилат (potassium salt of poliribouridilovy acid) – 0,107 mg / 0,0535 mg.

Auxiliary components as a part of liofilizat: sodium hydrophosphate (sodium phosphate 2-replaced), sodium chloride, potassium dihydrophosphate (potassium the phosphate 1-replaced anhydrous).

In addition as a part of drops nasal: dinatrium эдетат (Trilonum of B), water for injections.

Indications to use

Use of Poludanum is shown to adults and children for treatment of viral pathologies.

Lyophilisate for preparation of solution for injections

• The keratitis, keratoiridotsiklit (keratouveit), a stromal keratitis;
• Adenoviral and herpetic keratoconjunctivitis;
• Chorioretinitis;
• Iridocyclitis;
• Optic neuritis.

Lyophilisate for preparation of eye drops

• Herpetic and adenoviral conjunctivitis;
• Keratitis;
• Superficial keratoconjunctivitis.

Lyophilisate for preparation of nasal drops and a drop nasal

• Acute respiratory viral infections;
• Flu.

Contraindications

Patients cannot appoint Poludanum with hypersensitivity to its components.

Besides, contraindications for administration of drug in an anterior chamber of an eye:

• Infection of adnexal bosoms;
• Infection of teeth;
• Conjunctivitis (in the presence in crops from a conjunctiva of pathogenic microflora);
• Keratoiridotsiklita with an ulceration of a front surface of a cornea.

Route of administration and dosage

Lyophilisate for preparation of solution for injections
Drug is intended for subconjunctival introduction.

For solution preparation contents of a bottle or an ampoule dissolve in 1 ml of water for injections or 0,5% of solution of novocaine.

The recommended dosing:

• Uncomplicated pathologies: on 0,5 ml under a conjunctiva of 1 times a day or every other day, only 5-20 injections;
• Endothelial forms of a herpetic keratoiridotsiklit: in the conditions of the operating room slowly enter into an anterior chamber of an eye on 0,3-0,6 ml of 1 times in 3 days, only 3-5 injections (solution is prepared with water for injections);
• Herpetic defeat of back departments of an eye (optic neuritis, chorioretinitis, uveitis): periokulyarno (retrobulbarno, parabulbarno) – on 1 ml of 1 times in 2 days, only 10-20 injections.

At treatment of children Poludanum is dissolved in water for injections and enter 0,25 ml under a conjunctiva of 1 times in 2 days, only 8-10 injections.

For therapy of fresh rashes of shingles on face skin at a herpetic keratitis it is necessary to dissolve in 10-20 ml 0,5% of solution of novocaine contents of two bottles of drug and to enter subcutaneously on the course of rashes, the procedure is carried out every other day, by only 3-6 injections.

Lyophilisate for preparation of eye drops
Ready solution is intended for instillations in a conjunctival sac of an eye.

For preparation of drug it is necessary to add to contents of a bottle 2 ml of water for injections and to shake up before full dissolution of lyophilisate.

The recommended dosing:

• Adults: in an initiation of treatment dig in 1-2 drops of 6-8 times a day, then, at decrease in inflammatory process – 3-4 times a day;
• Children: in an initiation of treatment – on 1-2 drops 3-4 times a day, then, at decrease in inflammatory process – 1-2 times a day.

Ready solution can be stored in the refrigerator and to use within 7 days.

In the absence of therapeutic effect after 7 days of treatment it is necessary to see a doctor and to consider a question of purpose of drug in the form of subconjunctival injections.

Lyophilisate for preparation of nasal drops and a drop nasal
Ready solution of lyophilisate and drop apply locally in the form of drops in a nose.

From lyophilisate it is necessary for preparation of solution in a bottle (to the tag specified on the label) to add boiled chilled water and to shake up.

It is recommended to begin use of each of means no later than the first two days from the moment of emergence of symptoms of an exacerbation of a disease.

The recommended dosing for adults: on 2 drops in each nasal course of 5 times a day. Duration of treatment is 5 days.

Side effects

Against the background of use of Poludanum allergic reactions are possible.

Administration of drug subkonjyunktivalno causes strengthening of a superficial injection of vessels of an eye, insignificant hypostasis of a lower eyelid.

In case of an injection in an anterior chamber of an eye emergence of hemorrhages in an injection site, passing increase in intraocular pressure is possible.

When using drug in the form of eye drops strengthening of a conjunctival injection, emergence of an itch and separate follicles in the lower transitional fold, feeling of a foreign body in an eye is possible.

Special instructions

Injection introduction of Poludanum is appointed in the absence of clinical effect after 7 days of use of eye drops.

Side effects after drug withdrawal disappear in 1-3 days.

Medicinal interaction

At simultaneous use with fermental means, antiviral and immunomodulatory activity of Poludanum decreases.

The combination therapy with drugs for treatment of viral infections and antibiotics is shown.

Terms and storage conditions

To protect from children.

To store in the protected from light, dry place at a temperature: lyophilisate for preparation of solution for injections – to 4 °C, lyophilisate for preparation of eye and nasal drops – to 8 °C, a drop nasal – to 30 °C.

Period of validity: lyophilisate – 4 years, drops nasal – 2 years.