Sermion

Sermion – the medicine promoting improvement of cerebral and peripheric circulation.

Pharmacological action of Sermion

Active agent of Sermion – ницерголин, has alfa1-adrenoceptor blocking effect, improving peripheric and cerebral circulation.

Sermion's use promotes decrease in aggregation of thrombocytes, improvement of hemodynamic and metabolic processes in a brain and haemo rheological indicators of blood, and also to increase in speed of a blood-groove in upper and lower extremities.

Sermion according to the instruction acts gradually and demands prolonged use.

Release form

Sermion release in a look:

• Round orange tablets, the coated, containing 5 mg (on 15 pieces in the blister), 10 mg (on 25 pieces in the blister) and 30 mg (on 15 pieces in the blister) active agent – a nitsergolin. Excipients – sodium carboxymethylcellulose, hydrophosphate calcium a dihydrate, magnesium stearate, cellulose microcrystallic;
• Lyophilisate for preparation of solution for injections (porous mass or powder of white color), with the enclosed solvent. In the bottles containing 4 mg of a nitsergolin. Excipients – tartaric acid and lactoses monohydrate.

Sermion's analogs

Sermion's analogs on active ingredient are medicines Nitsergolin and Sermion (in the form of tablets) and Nitsergolin-Fereyn (in the form of lyophilisate for solution preparation).

Drugs Vazobral, Digidroergokristina мезилат and Redergin belong to Sermion's analogs on a way of action.

Indications to Sermion's use

According to the instruction Sermion is shown to use at the acute and chronic cerebral metabolic and vascular disorders which resulted:

• Atherosclerosis;
• Fibrinferment or vascular embolisms of a brain;
• Arterial hypertension.

According to indications Sermion appoint at:

• Acute tranzitorny disorder of cerebral circulation;
• The headache caused by a vasospasm;
• Vascular dementia.

Also Sermion's use is effective at treatment:

• Organic and functional arteriopatiya of extremities;
• The syndromes caused by disturbance of a peripheral blood-groove;
• Raynaud's diseases.

In some cases Sermion and analogs of drug appoint parenterally as an additional tool for treatment of hypertensive crisis.

Contraindications

Sermion according to the instruction it is contraindicated to apply in cases:

• Recently postponed acute myocardial infarction;
• Disturbances of orthostatic regulation;
• The expressed bradycardia;
• Acute bleeding;
• Hypersensitivity to a nitsergolin.

According to indications Sermion it is possible to apply at pregnancy only under control of the doctor as safety of use of drug during this period is not studied.

Sermion's use in the period of a lactation is not recommended.

According to Sermion appoint with care at gout in the anamnesis and a hyperuricemia, and also in combination with the medicines breaking removal and metabolism of uric acid.

Sermion route of administration

The way of introduction, duration and Sermion's dose according to the instruction depend on the nature of a disease. In certain cases treatment is begun with parenteral administration then pass to a dosage form of tablets (for the supporting treatment).

Pill Sermion according to the instruction is taken through equal intervals of time three times a day in a dose by from 5 to 10 mg.

Duration of use is defined by the doctor, however in most cases it makes not less than several months.

At treatment of vascular dementia Sermion according to indications appoint in a dosage 30 mg twice a day. Each six months of therapy it is recommended to consult with the doctor for clarification of expediency of continuation of the carried-out therapy.

Intramusculary Sermion's use is shown in a dosage of 2-4 ml 2 times a day.

Intravenously the drug is administered slowly in a dose of 4-8 mg divorced in 100 ml of 5-10% of solution of a dextrose or 0,9% of solution of sodium of chloride. According to indications Sermion in this dosage it is possible to enter several times a day.

Vnutriarterialno is entered, as a rule, by 4 mg of the drug divorced in 10 ml of solution of sodium of chloride (0,9%) within 2 minutes.

At renal failures Sermion's dose is reduced according to reviews.

At overdose Sermion can lead to the expressed lowering of arterial pressure. Special treatment is not required, except cases of sharp disturbance of blood supply of a brain when use of symptomatic means is recommended (under constant control of arterial pressure).

Sermion according to indications it is necessary to take with caution along with hypotensive drugs.

As a rule, drug in therapeutic doses does not exert impact on arterial pressure. However in certain cases at hypertensia Sermion according to reviews can lead to gradual pressure decrease.

Side effects of Sermion

As a rule, Sermion is according to reviews had well, and the caused side effects have moderate character.

According to responses Sermion in rare instances leads to disturbance of cardiovascular system that is shown as dizziness, the expressed lowering of arterial pressure and feeling of heat. To avoid possible emergence of arterial hypotension, after parenteral administration of Sermion it is recommended to accept horizontal position for several minutes.

Increase in concentration of uric acid in blood is in certain cases recorded (irrespective of duration of therapy and the accepted drug dose).

Besides, Sermion according to reviews can cause:

• Drowsiness or sleeplessness;
• Skin rashes;
• Dispepsichesky phenomena.

Storage conditions

Sermion – the medicine of a prescription issue relating to the list B. It is not necessary to exceed a drug period of storage: for the lyophilized powder for injections – 4 years, for tablets – 3 years.