Setegis

Setegis – the synthetic drug used at a benign hyperplasia of a prostate and arterial hypertension.

Pharmacological action

Active agent of Setegis blocks alfa1-adrenoceptors of unstriated muscles of a neck and a triangle of a bladder, a proximal part of a prostate and urethra.

At a benign hyperplasia of a prostate Setegis contributes to normalization of an urination, without exerting at the same time impacts on the prostate size.

Besides, active agent of Setegis has anti-hypertensive effect, reduces arterial pressure and before - and an afterload on heart, and also reduces venous return to heart.

Prolonged use of drug, as a rule, does not cause development of reflex tachycardia.

The maximum therapeutic effect of Setegis's use according to reviews develops in 2-3 hours after intake. Action duration – not less days.

Release form

Tablets Setegis contain 1 mg (with a text of "E451"), 2 mg (with a text of "E452"), 5 mg (with a text of "E453") and 10 mg (with a text of "E454") active agent – a terazozin.

– ariavit auxiliary components monohydrate, starch corn prezhelatinizirovanny sanst yellow, magnesium stearate, K-30 povidone, talc, lactoses.

On 10 tablets in blisters.

Setegis's analogs

Drugs Terazozin, Kornam and Terazozin-Tev belong to Setegis's analogs containing the same active component.

On a way of action medicines Artezin, Doksaprostan, Zokson, Doksazozin, Cardura, Prazozinum, Urokard, Kamiren, Ebrantil and Pyrroxanum belong to the closest analogs of Setegis.

Indications to Setegis's use

According to the instruction Setegis is shown to use:

• For treatment of arterial hypertension;
• As symptomatic therapy of a benign hyperplasia of a prostate.

Contraindications

Setegis according to the instruction it is contraindicated to apply:

• At children's age;
• At hypersensitivity to a terazozin or other alpha adrenoblockers.

At pregnancy, as well as in the period of a lactation, Setegis it is necessary to take with caution.

Setegis according to reviews also appoint with care at:

• Arterial hypotension;
• Disturbances of cerebral circulation;
• Coronary heart disease or other heart diseases;
• Insulin-dependent diabetes mellitus;
• Predispositions to orthostatic hypotension;
• Hypertensive retinopathy of III or IV degrees;
• Abnormal liver functions and kidneys.

Setegis route of administration

As a rule, tablets Setegis appoint once a day (before going to bed) in an initial dose 1 mg.

Increase in a dosage is recommended to be carried out gradually, is not more often than once a week to avoid development of arterial hypotension.

The maintenance dose of drug at arterial hypertension varies from 1 to 5 mg.

According to the instruction Setegis at a benign hyperplasia of a prostate accept 5-10 mg, the most admissible dose of drug once a day – 20 mg.

Setegis's efficiency at a benign hyperplasia of a prostate can be estimated not earlier than in one-two months of treatment.

To people of advanced age, and also at a renal failure correction of a dose of Setegis is not required.

At overdose by Setegis and analogs can be observed:

• Lack of coordination of movements;
• Arterial hypotension;
• Syncope.

For treatment the patient is recommended to carry out symptomatic therapy and to give horizontal position with the raised legs.

At simultaneous use with diuretic drugs or other anti-hypertensive means Setegis's dose should be reduced.

Side effects of Setegis

Setegis according to reviews most often leads to disturbances of cardiovascular system. As a rule, after the first reception of tablets development of arterial hypotension which is followed by dizziness, and in certain cases – a faint is possible.

Setegis's reception according to reviews can bring in high doses to:

• Orthostatic hypotension;
• Weaknesses;
• Muscular pain;
• Drowsiness;
• Tachycardias;
• Dyspepsias;
• Stenocardias;
• To increase in body weight;
• Adynamy;
• To dizziness;
• To peripheral hypostases;
• To heart consciousness;
• To vision disorder;
• To priapism;
• Headache;
• To asthma;
• To anaphylactic reactions;
• To nausea and vomiting;
• Puffinesses of a mucous membrane of a nose.

It is necessary to be careful at simultaneous use of Setegis with other anti-hypertensive medicines to avoid strengthening of their action.

Storage conditions

Setegis treats anti-hypertensive drugs of a prescription issue. It is not necessary to store tablets longer than 36 months.