Спазмекс

Спазмекс - M-holinoblokator, a spasmolysant.

International name – Trospiya chloride

Form of release and structure

Спазмекс is issued in the form of tablets on 5 mg, and tablets coated on 15 and 30 mg.

Each tablet contains 5 mg a chloride trospiya. As excipients are used: lactoses monohydrate, starch corn, starched glikolit sodium, povidone (To 25), stearic acid, silicon dioxide colloid.

Tablets with a cover contain 15 or 30 mg a chloride trospiya. Excipients: cellulose microcrystallic, lactose monohydrate, stearic acid, starched glikolit sodium, povidone (To 25), starch corn, silicon dioxide colloid, titanium dioxide, hypromellose

Pharmacological action of Spazmeks

Trospiya chloride – the quarternary ammonium basis, from group of anticholinergics. The competitive antagonist of acetylcholine on muskarinovy receptors of postsynaptic membranes, renders the weakening effect on smooth muscles.

Quicker than analogs of Spazmeks reduces activity of a detruzor of a bladder owing to what there is an increase in its volume, desires to an urination and by that the frequency of episodes of an urgentny incontience of urine is considerably reduced are suppressed. Спазмекс similar to a papaverine has ganglioblokiruyushchy action, and also myotropic action. The central effects are absent.

After oral administration of Spazmeks the maximum concentration in a blood plasma comes in 4-6 hours. The elimination half-life averages from 5 to 18 hours. Drug does not kumulirut. Linkng with proteins of a blood plasma makes 50-80%. Only of analogs of Spazmeks it is almost not subject to metabolism in a liver. It is removed by kidneys, about 10% in the form of the metabolite which is formed hydrolysis of radio bonds, other part of drug leaves in an invariable look.

Indications to use

• urgentny desires to an urination caused by idiopathic hyperreactivity of a detruzor which cause neuroregulation disturbances can be (injuries, and also the inborn and acquired diseases of a spinal cord, multiple sclerosis);
• complex therapies of cystitis with imperative symptomatology;
• enuresis – day and night;
• pollakiuria;
• incontience of urine of the mixed form.
• individual intolerance trospiya of chloride or other components of Spazmeks;
• ischuria for the anatomic reasons (a tumor, features of structure of an urethra, a prostate hyperplasia);
• the broken peristaltics or obstruction of intestines;
• closed-angle glaucoma;
• tachyarrhythmia;
• myasthenia гравис;
• it is also contraindicated to children up to 14 years.
• diseases of cardiovascular system at which increase in heart rate as tachycardia, coronary heart disease, chronic heart failure is undesirable;
• thyrotoxicosis;
• to hernia of an esophageal opening of a diaphragm in combination with a reflux esophagitis;
• diseases of the alimentary system with obstructive states;
• intestines atonies at the elderly or weakened patients;
• paralytic impassability of intestines;
• chronic inflammatory processes of intestines (ulcer colitis, disease Krone);
• renal failure;
• vegetative neuropathy;
• chronic diseases of lungs;
• toxicosis at pregnancy;
• Down syndrome.

Contraindications

To accept with precaution at:

• diseases of cardiovascular system at which increase in heart rate as tachycardia, coronary heart disease, chronic heart failure is undesirable;
• thyrotoxicosis;
• to hernia of an esophageal opening of a diaphragm in combination with a reflux esophagitis;
• diseases of the alimentary system with obstructive states;
• intestines atonies at the elderly or weakened patients;
• paralytic impassability of intestines;
• chronic inflammatory processes of intestines (ulcer colitis, disease Krone);
• renal failure;
• vegetative neuropathy;
• chronic diseases of lungs;
• toxicosis at pregnancy;
• Down syndrome.

Pregnancy and period of a lactation

Spazmeks's instruction speaks about a possibility of acceptance by pregnant women or the reproaching mothers of drug, only if need of mother for treatment exceeds possible risk for the child. Clinical trials of use of Spazmeks by pregnant women and nursing mothers were not seen off.

Dosage of Spazmeks and the instruction to use

Pill of Spazmeks is taken to food, without chewing and washing down with water. Drug of Spazmeks is appointed by the doctor depending on a condition of the patient and the overall clinical picture. Спазмекс is accepted orally. The daily dose makes 30 – 45 mg. also is divided equal parts into three receptions. At increase in a daily dosage up to 45 mg. acceptance of 30 mg and 15 mg is possible in the morning in the evening. As well as at the majority of analogs of Spazmeks the standard course of therapy makes 2-3 months. At the positive effect expressed in disappearance of symptomatology performing antirecurrent treatment for 2-4 weeks is recommended. At longer therapeutic courses, the attending physician reconsiders a question of need of continuation or a stop of treatment each 3-6 months. The daily dose more than 20 mg is not recommended to patients with a renal failure, Spazmeks's instruction. Exceeding of a daily dose in 135 mg is inadmissible.

Side effects of Spazmeks

Considering group parasympathetic action of Spazmeks, it can be observed: perspiration reduction, dryness in a mouth, a lock, feeling of completeness of a stomach, disturbance of accommodation and a tachyarrhythmia. The comments received about practical application of Spazmeks showed possible manifestation of side effects in the form of allergic reactions on skin.

The symptoms of overdose, known from reviews of Spazmeks of therapy, are the expressed anticholinergic symptoms, such as tachycardia, vision disorder, dryness in a mouth, reddening of integuments. Spazmeks's overdose is treated by purpose of adsorbents and a gastric lavage. Local introduction of Pilocarpinum is shown to patients with glaucoma. At an ischuria catheterization becomes. In hard cases cholinomimetics are appointed. If symptoms are not removed and the expressed tachycardia with unstable blood circulation is shown, beta-blockers, under control of an ECG are entered.

Spazmeks's interaction with other drugs

Combined use of Spazmeks with amantadiny, tricyclic antidepressants, quinidine, antihistaminic medicines, Disopyramidum, beta адреностимуляторами, strengthens their anticholinergic effect.

Special instructions

Before a medical course of Spazmeks it is necessary to exclude the organic reasons of an incontience of urine and a pollakiuria, such as renal or heart failure, swelled up urinary tract.

If function of a sphincter of an urethra is broken, it is required to provide full release of a bladder through a catheter.

As according to responses of Spazmeks can break sight, it is recommended to refrain for the period of performing therapy from driving of vehicles and any potentially dangerous activity.

Spazmeks storage conditions

It is recommended to store Spazmeks in the dry, protected from light place unavailable to children. Temperature of storage is 15 - 25 °C.

Period of validity of 5 years.