Spiriva

Spiriva – synthetic broncholitic drug.

Pharmacological action

Active component of Spiriva has bronkhodilatiruyushchy effect.

As a result of Spiriva's use spasms of smooth muscles of bronchial tubes, at the same time (considerably decrease when using in therapeutic dosages) drug does not cause the system side effects inherent to anticholinergic group of medicines. Effect of drug depends on a dose.

After use of a single dosage the therapeutic effect occurs within half an hour, and for days considerable improvement of functions of lungs is observed. Such long action of Spiriva is connected with the slowed-down release (in comparison with an ipratropiya bromide) from communication with M3 receptors.

The expressed bronkhodilatiruyushchy effect occurs, as a rule, for the third day of use of Spiriva.

Besides, as a result of therapy the frequency of exacerbations of the chronic obstructive pulmonary disease (COPD) considerably decreases and improvement of quality of life during the entire period of treatment is observed.

Release form

Drug Spiriva is produced in the form of the solid light green gelatin capsules containing white powder for inhalations. One capsule contains 18 mkg of active agent – a bromide tiotropiya. On 10 capsules in blisters complete with HandiHaler inhaler.

Spiriva's analogs

Spiriva's analogs on active ingredient are not released.

The closest analogs of Spiriva on a way of action:

• Aerosol for inhalations – Atrovent of N, Ipravent, Truvent, Troventol;
• Solution for inhalations – Atrovent, Ipramol Steri-Neb, Ipratropium Steri-NEB.

Indications to Spiriva's use

According to the instruction Spiriva is appointed as a maintenance therapy at a chronic obstructive pulmonary disease, including:

• Emphysema;
• Chronic bronchitis.

Contraindications

It is contraindicated to apply Spiriva according to the instruction:

• In the first trimester of pregnancy;
• Aged up to 18 years;
• At hypersensitivity to Spiriva's components, and also to atropine or its derivatives.

Drug Spiriva is appointed with care at:

• Prostate hyperplasia;
• To closed-angle glaucoma;
• Obstructions of a neck of a bladder.

At Spiriva's use it is necessary to consider that drug should not be used for stopping of bad attacks of a bronchospasm.

Spiriva route of administration

According to the instruction Spiriva is applied on one capsule in the form of inhalations once a day. For performing inhalations it is necessary to use only an inhaler of HandiHaler which is applied complete with drug. For increase in efficiency of Spiriva it is necessary to use drug at the same time days.

People at advanced age can use medicine according to the same scheme.

At renal failures correction of a dose is required only in cases of a concomitant use with means which are more removed by kidneys.

At overdose by Spiriva there can be symptoms which are inherent to drugs of anticholinergic action:

• Accommodation disturbances;
• Dryness in a mouth;
• Increase in heart rate.

At accidental reception of capsules Spiriva inside the probability of development of acute intoxication is extremely small that is connected with low bioavailability of drug.

Inhalations using capsules Spiriva can be combined with other medicines which are usually appointed at treatment of a chronic obstructive pulmonary disease, namely with:

• Sympathomimetics;
• Peroral and inhalation glucocorticoid means;
• Methylxanthine derivatives.

Side effects of Spiriva

Spiriva's use according to reviews can lead to development of the following disturbances:

• The alimentary system – small dryness in a mouth, oral cavity candidiasis, a lock, a gastroesophageal reflux. These frustration most often disappear independently, and drug withdrawal or special treatment do not demand;
• Cardiovascular system – heartbeat and tachycardia;
• Urinary system – infections of an uric path, the complicated urination and a delay of an urination (it is preferential at men with predisposition);
• Respiratory system – a bronchospasm, nasal bleeding, a dysphonia, cough, and in rare instances – local irritation of a throat;
• The central nervous system – dizziness.

In isolated cases at Spiriva's use according to reviews develop:

• Quincke's disease;
• Increase in intraocular pressure;
• Supraventricular tachycardia;
• Intestinal impassability (in certain cases – paralytic Ilheus);
• Sight illegibility;
• Glaucoma;
• Ciliary arrhythmia;
• Dysphagy.

Hypersensitivity reactions, rash, itch and urticaria according to reviews belong to the most probable allergic reactions at Spiriva's use.

After the carried-out Spiriva's inhalation development of reactions of immediate hypersensitivity or a bronchospasm in certain cases is possible.

Storage conditions

Spiriva treat a number of broncholitic drugs for which issue the recipe is necessary.

Period of storage of capsules – no more than 2 years. At storage drug Spiriva cannot be frozen.

The blister after opening needs to be used within nine days.

The term of use of the HandiHaler device – 1 year.