Sulperazon

Sulperazon – an antibiotic from group of the protected cephalosporins 3 generations.

Pharmacological action of Sulperazon

Two active components - a semi-synthetic antibiotic Tsefoperazon and inhibitor β-лактамаз Sulbaktam are Sulperazon's part. Tsefoperazon perniciously affects microorganisms, sensitive to it, breaking synthesis of a mukopeptid of their cell wall during active reproduction. Sulbaktam separately has no significant antibacterial activity, he is capable to destroy only bacteria of the sort Neisseriaceae and Acinetobacter. However, he effectively unites to the main β-lactamelements (the protective enzymes of microorganisms steady to β – to laktamny antibiotics), blocking their destroying action on Tsefoperazon. Such protective properties of Sulbaktam concerning Tsefoperazon are proved by a research on bacteria, steady against Tsefoperazon. The combination of these two antibacterial agents gives new, stronger drug.

Sulperazon destroys the bacteria sensitive to Tsefoperazon as gram-positive (different types of stafilokokk and streptococci), and gram-negative (intestinal, pyocyanic and hemophilic sticks, a klebsiyella, an enterobakter, salmonellas, shigellas, gonokokk, acinetobacters, proteas, iyersiniya and others).

According to the instruction, Sulperazon is capable to destroy and anaerobic bacteria (bacteroids, clostridiums, etc.). Apparently, it possesses a broad spectrum of activity on different microorganisms.

The drug pharmacodynamics is quite deeply studied. It is well distributed in body tissues, concentration of medicine in serum directly depends on amount of the administered drug. Sulperazon, mostly, is brought by kidneys, it is a little more – with bile in an intestines gleam.

Release form

Sulperazon release in bottles, in the form of powder for preparation of solution for injections. One packaging contains 1 g of Tsefoperazon and 1 g of Sulbaktam, calculation of a dose is conducted on Tsefoperazona.

Indications to Sulperazon's use

Sulperazon, according to the instruction, use for treatment of the infections caused by microbes, sensitive to it. It can be, for example, infections of upper and lower respiratory tracts and ENT organs (sinusitis, bronchitis, tracheitis, laryngitis, pneumonia, pleurisy, etc.), infections of urinary tract and kidneys (cystitis, an urethritis, pyelonephritis, a glomerulonephritis), abdominal infections (peritonitis, cholecystitis), infections of skin and soft tissues (a furunculosis, abscesses of skin and hypodermic cellulose), bones and joints (osteomyelitis, arthritis), bodies of a small pelvis, at meningitis and sepsis, in case of gonorrhea.

Contraindications

According to the instruction, Sulperazon it is impossible to apply if at the patient was or there is an allergy to other antibiotics of a tsefalosporinovy or penicillinic row (their chemical structure is very similar, and there can be cross allergic reactions).

Use of drug during pregnancy and breastfeeding is possible only when the estimated advantage of treatment is more, than harm for the child.

Application instruction of Sulperazon

Sulperazon it is possible to enter intravenously and intramusculary. According to the instruction, Sulperazon apply in a daily dose to adult 2 – 4 g, to children – at the rate of 40-80 mg/kg. It is divided into two equal parts and entered in 12 hours.

To prepare solution for intravenous use, with drug add 6,7 ml of solvent to a bottle (0,9% solution of sodium chloride, 5% glucose solution, sterile water for injections), then it is necessary to add initial solution up to the volume of 20 ml. As initial solution, because of incompatibility, it is impossible to apply Ringer's solution, in this case prepare solution for infusion step by step: part in a bottle with one of the listed solutions, and then add Ringer's solution to Sulbaktam's concentration of 5 mg/ml. Duration of infusion is from 15 minutes till 1 o'clock.

To prepare solution for intramuscular introduction, for initial dissolution use water for injections, and then add 2% Lidocaine solution. The total amount of solvent on a bottle has to make 6,7 ml, then concentration Tsefoperazon/Sulbaktam will make 125 mg / 125 mg in 1 ml of 0,5% of solution of Lidocaine.

At heavy infections the daily dose of Sulperazon can be increased to 8 g (4 g of Tsefoperazon and 4 g of Sulbaktam).

Duration of use is defined by the doctor on the basis of clinical and datas of laboratory. Sulperazon today – an antibiotic for treatment of the heavy infections demanding hospitalization.

During a course of treatment it is necessary to control functions of a liver and kidneys periodically. It is impossible to mix Sulperazon's solutions and aminoglycosides because of their incompatibility. If during treatment to take alcohol, then the disulfiramopodobny effect can be observed.

Side effects of Sulperazon

Sulperazon is capable to make sick, vomiting, diarrhea, biochemical changes in blood, allergic dermatitis, a small tortoiseshell, a neutropenia, a headache, fever, reactions in an injection site (phlebitis – a vein wall inflammation). At intolerance of drug there can be an acute anaphylaxis.