Sulpiridum

Sulpiridum – a neuroleptic, antipsychotic medicine.

Structure and form of release of Sulpiridum

Drug is produced in two dosage forms:

• The tablets of white color containing active agent – Sulpiridum of 50 or 200 mg, on 10 tablets in packaging or on 30 tablets in bank. Auxiliary components: potato starch, lactose, magnesium stearate, talc, gelatin, MKTs.
• Solution for intramuscular introduction, the transparent and colourless, containing 100 mg of Sulpiridum. In ampoules on 2 ml, on 10 ampoules in packaging. Auxiliary components: sodium chloride, water for injections, sulphuric acid solution.

Analogs of Sulpiridum are the following medicines: Beta max., Prosulpin, Eglek, Eglonyl.

Pharmacological action

According to the instruction Sulpiridum has antipsychotic, antiemetic and antidepressive effect.

According to reviews Sulpiridum in small dosages is effective as supportive application at psychosomatic diseases, in particular, drug stops negative mental symptoms at an ulcer of a 12-perstny gut and a stomach. At an irritable colon Sulpiridum reduces intensity of abdominal pains and improves a clinical condition of the patient.

Also use of drug in small dosages is effective at dizziness of various etiology. Drug has the central antiemetichesky effect and stimulates production of prolactin.

Indications to use of Sulpiridum

According to the instruction Sulpiridum is shown as monotherapy or in a combination with other psychotropic medicines at the following states and diseases:

• acute delirious states;
• schizophrenia;
• depressions of various etiology.

Contraindications

In the instruction to Sulpiridum the following contraindications are specified:

• maniacal psychosis;
• aggression;
• hypersensitivity to one or several components of drug;
• convulsive attacks;
• pheochromocytoma;
• giperprolaktinemiya;
• prolactin - dependent tumors (a breast cancer, hypophysis prolaktinoma);
• affective frustration;
• children's age up to 14 years;
• acute poisoning with analgetics, hypnagogues or alcohol;
• pregnancy and breastfeeding.

In addition, it is not recommended to accept drug or analogs of Sulpiridum in a combination with sultopridy and agonists of dofaminergichesky receptors (Apomorphinum, энтакапон, ропинирол, прамипексол, амантадин, хинаголид, каберголин, лисурид, Bromocriptinum, перголид, прамипексол, piribedit). The exception is made by patients with Parkinson's disease.

Sulpiridum tablets according to the instruction are in addition contraindicated:

• at deficit of lactase and a sprue of galactose/glucose;
• at a galactosemia.

According to reviews Sulpiridum should be taken with caution at advanced age, and also at the following diseases:

• arterial hypertension;
• epilepsy;
• serious illness of heart;
• dysmenorrhea;
• glaucoma;
• ischuria;
• stenocardia;
• prostate hyperplasia;
• liver or renal failure;
• malignant antipsychotic syndrome in the anamnesis.

Route of administration of Sulpiridum and mode of dosing

According to the instruction Sulpiridum in tablets is accepted inside.

At acute delirious psychosis, chronic and acute schizophrenia the initial dosage, as a rule, makes 600-1200 mg a day, divided into several receptions.

At a depression the dosage of drug or an analog of Sulpiridum from 150 to 600 mg a day divided into several receptions is effective.

At dizziness Sulpiridum is according to reviews effective in a dose of 150-200 mg a day. Duration of therapy makes two weeks.

At chronic and acute psychoses appoint Sulpiridum according to the instruction in the form of solution for intramuscular introduction. Begin therapy with a dosage of 400-800 mg a day. Preferential, treatment continues two weeks, with the purpose to reach the most effective dosage. As soon as the condition of the patient allows, it is necessary to pass to reception of Sulpiridum or analogs in the form of tablets.

Side effects of Sulpiridum

According to responses Sulpiridum causes the following by-effects:

• Alimentary system: nausea, a lock, heartburn, dryness in a mouth, vomiting, increase in activity of hepatic transaminases and an alkaline phosphatase in blood serum.
• Endocrine system: a gynecomastia, frigidity and impotence, increase in body weight, the strengthened sweating, a reversible giperprolaktinemiya, disturbance of a menstrual cycle.
• Cardiovascular system: decrease or increase in the ABP, tachycardia, lengthening of a QT interval.
• TsNS: drowsiness, headache, dizziness, aphasia, extrapyramidal syndrome, oral automatism. Small doses of Sulpiridum according to reviews can cause irritability, frustration of a dream, excitement, visual acuity disturbance.
• Allergic reactions: eczema, skin rash, itch.

Medicinal interaction of Sulpiridum

Simultaneous use of drug or analog of Sulpiridum with:

• levodopa - reduces action of Sulpiridum;
• hypotensive drugs - strengthens their hypotensive effect and increases probability of orthostatic hypotension;
• drugs, the oppressing TsNS, antibechic drugs of the central action and clonidine - strengthens their oppressing effect on TsNS.

Storage conditions

Drug is stored in the dry dark place not longer than three years.