Tinox

Tinox – the synthetic drug reducing expressiveness of symptoms of ischemia of a myocardium and arterial pressure.

Pharmacological action

Active component of Tenoks – амлодипин, has anti-anginal and hypotensive effect. Drug contributes to normalization of arterial pressure, and also increases resistance of an organism to exercise stresses at coronary heart disease, reducing at the same time the frequency of attacks of stenocardia.

Reduction of arterial pressure happens at the expense of a direct impact on unstriated muscles of vessels owing to what the general peripheric resistance of vascular system decreases, and arterial pressure decreases without development of reflex tachycardia.

Anti-anginal action of Tenoks, according to the instruction, provides expansion of coronary and peripheral arteries and arterioles. Тенокс reduces expressiveness of symptoms of ischemia of a myocardium at stenocardia and the existing need of a myocardium for oxygen, reduces preload of heart, and also prevents a spasm of coronary arteries.

Form of release of Tenoks

Tinox is produced in a dosage form of the tablets containing an amlodipin on 5 mg and 10 mg everyone. On 30 pieces and 90 pieces in packaging.

Tenoks's analogs

Tenoks's analogs on the mechanism of action are the drugs Adalatum, Zanidip-Rekordati, Kordafen, Kordafleks, Kordipin, Corinfarum, Latsipil, Nimotop, Nifedipin, Oriental cherries, Felodipin, Foridon, Eskordi Kor.

Indications to Tenoks's use

Tinox according to the instruction is appointed at treatment:

• Arterial hypertension (the increased arterial pressure);
• Vasospastic (differently – spontaneous, or Printsmetal's stenocardias) or stable stenocardia.

According to reviews, Tenoks can be accepted both along with other drugs, and as monotherapy.

Contraindications

According to the instruction, it is contraindicated to apply Tenoks:

• At hypersensitivity to drug components;
• With the lowered arterial pressure (systolic – less than 90 mm of mercury.);
• At disturbance of outflow of blood from a left ventricle (including a mitral stenosis, an aorta stenosis, a subaortic hypertrophic stenosis – a thickening of a wall of a left ventricle);
• At treatment of the patients having unstable stenocardia (except Printsmetal's stenocardia);
• At treatment of patients with heart failure after the postponed myocardial infarction (for four weeks after an acute myocardial infarction);
• At pregnancy and feeding by a breast;
• At treatment of children up to 18 years.

With care appoint Tenoks the patient suffering from functional disorders of a liver, dekompensirovanny heart failure, a sick sinus syndrome, and also the patient with a diabetes mellitus, disturbances of a lipometabolism, to elderly patients.

Tenoks route of administration

At supertension and stenocardia of Tenoks accept in number of 5 mg once a day. If necessary the daily dose of drug is increased to 10 mg in one step. The maintenance dose of Tinox, according to the instruction, varies from 2,5 to 5 mg with frequency rate of reception – once a day.

In cases of vasospastic and stable stenocardia of Tenoks accept in number of 5-10 mg once a day. For prevention of stenocardia appoint 10 mg of Tenoks a day.

Side effects

At Tenoks's use, according to reviews, the following undesirable effects can be observed:

• Lowering of arterial pressure;
• Inflammation and destruction of walls of blood vessels (vasculitis);
• Hypostases of the lower extremities;
• Hyperemia of an upper body, including the person;
• Disturbance of a cordial rhythm;
• The pain arising in heart;
• Emotional mobility;
• Increased fatigue;
• Dizziness;
• Sleep disorder;
• Depression;
• Numbness of extremities;
• Adynamy;
• Vomiting;
• Discomfort and pain in epigastric area;
• Jaundice with disturbance of intake of bile in a duodenum (cholestasia);
• Meteorism, disturbance of a chair;
• Frequent and, in certain cases, painful desires to an urination;
• Dysuria, polyuria, nocturia;
• Decrease in a libido;
• Disturbances of an erection, gynecomastia;
• Pain in muscles and joints;
• Allergic reactions.

Besides, Tenoks's use, according to reviews, can promote development of a myasthenia, pancreatitis, nausea, headache, arthrosis, spasms, an asthma and faint.

Storage conditions

Tinox and analogs of drug store in the place unavailable to children. A period of storage – four years (at a temperature no more than 30 °C).